Results 71 to 80 of about 21,954 (152)
First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus
The FEBS Journal, EarlyView.The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi +15 more
wiley +1 more source
Do dietary patterns in older men influence change in homocysteine through folate fortification? The Normative Aging Study [PDF]
Objective We aimed to describe the difference in B-vitamin intake and in plasma B-vitamin and homocysteine concentrations before and after folic acid fortification, in relation to dietary patterns. Design The Normative Aging Study (NAS) is a longitudinal
Groot, C.P.G.M., de +5 more
core +2 more sources
The FEBS Journal, EarlyView.Cystathionine β‐synthase (CBS) is an essential enzyme involved in cysteine metabolism. The mutation R336C, associated with severe homocystinuria and of high incidence in Qatar, reduces its activity. Our research shows that this mutation does not destabilize the enzyme fold but subtly alters the tautomeric equilibrium of the PLP cofactor within the ...
Carolina Conter +10 more
wiley +1 more source
Prebiotic Interconversion of Pyruvate and Lactate over Zeolite‐Supported Ni Catalyst
Angewandte Chemie, Volume 137, Issue 23, June 2, 2025.Synthetic zeolite Y‐supported Ni mineral can catalyze the interconversion of metabolically crucial pyruvate and lactate under hydrothermal vent conditions, which could pave the way for the modern biological process by lactate dehydrogenase and nicotinamide adenine dinucleotide.
Youngdong Song +4 more
wiley +2 more sources
The prevalence of the elevation serum alanine amino transaminase at gorgan in Northern Iran [PDF]
, 2011 The elevation of serum alanine aminotranferase levels is associated most commonly with some forms of liver diseases. The aim of this study was to determine the prevalence of elevated serum alanine aminotransferase levels and the possible liver damages in
Mansourian, A.R. +2 more
core
The FEBS Journal, EarlyView.Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona +11 more
wiley +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Bacteriophages impact soil bacteria through lysis, altering the availability of organic carbon and plant nutrients. However, the magnitude of nutrient uptake by plants from lysed bacteria remains unknown, partly because this process is challenging to investigate in the field.
Vlastimil Novak +10 more
wiley +1 more source
A Computational Approach for Identifying Plant-Based Foods for Addressing Vitamin Deficiency Diseases [PDF]
, 2015 Vitamins are nutrients that are essential to human health, and deficiencies have been shown to cause severe diseases. In this study, a computational approach was used to identify vitamin deficiency diseases and plant-based foods with vitamin content ...
Sarkar, Indra Neil, Yu, Christina
core +1 more source
Inhibition of pyridoxal kinase by the pyridoxal-gamma-aminobutyrate imine. [PDF]
Journal of Biological Chemistry, 1980 D M Abercrombie, D L Martin
openaire +2 more sources
Regorafenib‐Induced Hand‐Foot Skin Reaction in an Adolescent
Pediatric Dermatology, EarlyView.ABSTRACT Regorafenib is a multikinase inhibitor commonly used in the management of hepatocellular carcinoma, gastrointestinal stromal tumors (GIST), and colorectal cancer. It is also used off‐label for progressive or metastatic osteosarcoma, which is the most common primary bone malignancy in children and adolescents.
Kiera Murphy +3 more
wiley +1 more source