Results 81 to 90 of about 43,493 (297)
Ophthalmic acid accumulation in an Escherichia coli mutant lacking the conserved pyridoxal 5′-phosphate-binding protein YggS [PDF]
, 2016 Escherichia coli YggS is a highly conserved pyridoxal 5′-phosphate (PLP)-binding protein whose biochemical function is currently unknown. A previous study with a yggS-deficient E.
Ito, Tomokazu +3 more
core +1 more source
Current Insight into Human Ornithine Aminotransferase: A Review
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Human ornithine aminotransferase (hOAT) is a mitochondrial matrix pyridoxal‐5′‐phosphate enzyme (PLP) that catalyzes the reversible transfer of the δ‐amino group of L‐ornithine (L‐Orn) to α‐ketoglutarate (α‐KG) yielding glutamate‐5‐semialdehyde (GSA) and glutamate. GSA is prone to cyclize to Δ1‐pyrroline‐5‐carboxylate.
Fulvio Floriani +2 more
wiley +1 more source
PLP Induced Inhibition of Thymidylate Synthase Activity in T Lymphocytes
European Journal of Inflammation, 2003 The present study was undertaken in order to examine whether pyridoxine may be used as an inhibitor of thymidylate synthase, and thus, as an antiproliferative agent.
M. Palasopoulou +3 more
doaj +1 more source
Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges
The Chemical Record, EarlyView.Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley +1 more source
Nature-inspired radical pyridoxal-mediated C–C bond formation
Pyridoxal-5\u27-phosphate (PLP) and derivatives of this cofactor enable a plethora of reactions in both enzyme-mediated and free-in-solution transformations.
Kevin, Skinner +5 more
core +1 more source
Human placental vitamin B6 (pyridoxal) transport: normal characteristics and effects of ethanol
, 1992 The aims of this study were to define normal human placental transport of pyridoxal, an important form of vitamin B6 in pregnancy, and to determine the effect of short-term alcohol on this process. Our studies used the isolated single cotyledon from the
G. I. Henderson +4 more
core +1 more source
Genetic Tools in the Nakaseomyces clade for Evolutionary Comparisons of Signal Transduction Pathways
Yeast, EarlyView.ABSTRACT The genus Nakaseomyces provides four species that are closely related but have different characteristics. For example, N. glabratus (formerly known as Candida glabrata) is a common human pathogen, whereas N. bracarensis and N. nivariensis have been isolated in clinical settings but are not common human pathogens. N.
Maria Abraham +2 more
wiley +1 more source
InorganicsThe rise in the number of cancer cases and the dissemination of strains with multiple drug resistance in the world pose a serious threat to public health care and human well-being.
Daria V. Petrova +5 more
doaj +1 more source
Reaction of Furanoeremophilans with Pyridoxal
Natural Product Communications, 2008 Furanoeremophilan-10β-ol, a major component of Ligularia cymbulifera growing in northwestern Yunnan Province of China, reacted with pyridoxal or its 5′-phosphate at room temperature in aqueous solution to afford condensation products.
Atsushi Torihata, Chiaki Kuroda
doaj +1 more source
Discovery and Characterization of Pyridoxal 5’-Phosphate-Dependent Cycloleucine Synthases
Pyridoxal 5’-phosphate (PLP)-dependent enzymes are the most versatile biocatalysts for synthesizing non proteinogenic amino acids. a,a-disubstituted quaternary amino acids, such as 1-amino-1-cyclopentanecarboxylic acid (cycloleucine), are useful building
David A., Delgadillo +9 more
core +1 more source