Results 91 to 100 of about 63,427 (306)

Structural and functional defects of mitochondrial serine hydroxymethyltransferase genetic variants responsible for a novel neurodevelopmental syndrome

Frontiers in Chemical Biology
In 2020 seven genetic variants of the mitochondrial serine hydroxymethyl transferase (SHMT2) were linked to a novel brain and heart developmental syndrome.
Giovanna Boumis, Sara Breccia, Gianluca Pistoia, Sharon Spizzichino, Carlotta Zamparelli, Francesca Troilo, Adele Di Matteo, Carlo Travaglini Allocatelli, Roberto Contestabile, Angela Tramonti, Francesca Cutruzzolà, Giorgio Giardina   +11 more
doaj   +1 more source

Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

Molecular Microbiology, 2012
Pyridoxal‐5′‐phosphate (vitamin B6) is an essential cofactor for many important enzymatic reactions such as transamination and decarboxylation. African trypanosomes are unable to synthesise vitamin B6de novo and rely on uptake of B6 vitamers such as ...
Deuan C. Jones, M. Alphey, S. Wyllie, A. Fairlamb   +3 more
semanticscholar   +1 more source

Rethinking GABAergic therapy in neonatal seizures: Beyond Scylla and Charybdis

Epilepsia Open, EarlyView.
Raffaele Falsaperla, Vincenzo Sortino, Georgia Ramantani   +2 more
wiley   +1 more source

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş, Serap Göncü, Fatma Hepsağ, Nazan Koluman, Yesim Ozogul   +4 more
wiley   +1 more source

Beyond a dual role: how Purpureocillium lilacinum reprograms citrus metabolism for integrated biocontrol and growth promotion

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Plants harbor complex microbial communities that are fundamental to their health and productivity. Among them, endophytic fungi such as Purpureocillium lilacinum establish mutualistic associations, offering dual benefits as plant growth promoters and biocontrol agents.
Sana Bouzembila, Kamel Charaabi, Haytham Hamden, Salma Fadhel, Nesrine Tanfouri, Meriem Msaad Guerfali   +5 more
wiley   +1 more source

PLP Induced Inhibition of Thymidylate Synthase Activity in T Lymphocytes

European Journal of Inflammation, 2003
The present study was undertaken in order to examine whether pyridoxine may be used as an inhibitor of thymidylate synthase, and thus, as an antiproliferative agent.
M. Palasopoulou, C. Haitoglou, G. Papageorgiou, A. Dimitriadou   +3 more
doaj   +1 more source

Chirality in pyridoxal [PDF]

, 1989
Pyridoxal and its iminium derivatives form cyclic compounds via an intramolecular nucleophilic attack. This results in a configurational chirality on C4' which can be related to out-of-plane orientations around the C4C4' bond in the open forms.
Lier, van, P.M., Genderen, van, M.H.P., Buck, H.M., Buck, HM Henk, Genderen, MHP Marcel van, Lier, PM van   +5 more
core   +2 more sources

Data‐Driven Insights into Hyperkinetic Disorders in Neurodevelopmental Syndromes and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Childhood‐onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic ...
Hugo Morales‐Briceño, Shekeeb S. Mohammad, Rajeshwar Reddy Angiti, Velda Han, Michel Tchan, Russell C. Dale, Victor S.C. Fung   +6 more
wiley   +1 more source

Synthesis, Structural Characterization, Cytotoxicity, and Antibacterial Properties of Gold(III) Complexes with Hydrazones Derived from Vitamin B₆

Inorganics
The rise in the number of cancer cases and the dissemination of strains with multiple drug resistance in the world pose a serious threat to public health care and human well-being.
Daria V. Petrova, Aleksandra K. Isagulieva, Olga N. Sineva, Vera S. Sadykova, Maksim N. Zavalishin, George A. Gamov   +5 more
doaj   +1 more source

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[boxs]

Journal of Biological Chemistry, 2005
(R)-Roscovitine (CYC202) is often referred to as a “selective inhibitor of cyclin-dependent kinases.” Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat ...
S. Bach, M. Knockaert, J. Reinhardt, O. Lozach, S. Schmitt, B. Baratte, M. Koken, S. Coburn, Lin Tang, T. Jiang, D. Liang, H. Galons, J. Dierick, L. Pinna, F. Meggio, F. Totzke, C. Schächtele, Andrea Lerman, A. Carnero, Y. Wan, N. Gray, L. Meijer   +21 more
semanticscholar   +1 more source