Results 81 to 90 of about 48,907 (300)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Suicide inhibition of alpha-oxamine synthases:structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine [PDF]

, 2006
The suicide inhibition of the α-oxamine synthases by the substrate analog, L-trifluoroalanine was investigated. The inhibition resulted in the formation of a complex with loss of all three fluorine atoms.
Abboud, Alexeev, Astner, Berman, Clausen, Dawkins, Dmitriy Alexeev, Dominic J. Campopiano, Edgar, Eisenberg, Eliot, Faraci, Fearon, Ferreira, Gable, Grishin, Gukulan, Hanada, Hunter, Hunter, Ikushiro, Jones, Keller, Kerbarh, Kraulis, Lindsay Sawyer, Nicholas Tomczyk, Olivier Kerbarh, Otwinowski, Ploux, Ploux, Ploux, Rendina, Robert. L. Baxter, Rory Watt, Schmidt, Scott P. Webster, Sheldrick, Shoolingin-Jordan, Silverman, Silverman, Wang, Wang, Webster, Zamam, Zhang   +45 more
core   +1 more source

Diffusion and Chemical Degradation of Vitamin B6 in Chickpeas (Cicer arietinum L.) during Hydrothermal Treatments: A Kinetic Approach

Foods
Chickpeas are more sustainable than other food systems and have high a nutritional value, especially regarding their vitamin composition. One of the main vitamins in chickpeas is vitamin B6, which is very important for several human metabolic functions ...
Heba Shaban, Claus Kadelka, Stephanie Clark, Nicolas Delchier   +3 more
doaj   +1 more source

Comparative Analysis of the Effects of Different Cooking Methods on the Flavor and Nutritional Composition of Pepper (Capsicum annuum L.)

Future Postharvest and Food, EarlyView.
Different cooking methods (pan‐frying with oil and pan‐frying without oil) will affect the flavor and nutrition of chili fruit. Pan‐frying with oil diminishes the original flavor and nutritional value of peppers, whereas pan‐frying without oil enhances the nutritional quality and preserves the freshness of peppers.
Chenxi Ji, Qingjing Ye, Chenxu Liu, Zhuping Yao, Hongjian Wan, Meiying Ruan, Rongqing Wang, Guozhi Zhou, Chaochao Liu, Yuan Cheng   +9 more
wiley   +1 more source

Structural and biophysical analysis of important biomedical enzymes and nano-architectures [PDF]

, 2008
Dopa decarboxylase (DDC) is an important enzyme in the catecholamine biosynthesis pathways. Catecholamines, e.g., dopamine, serotonin, etc. often are the major neuromodulators or neurotransmitters.
Chattopadhyay, Arundhati
core   +1 more source

The binding of pyridoxal to hemoglobin.

Journal of Biological Chemistry, 1982
Concentrative uptake of pyridoxal by human erythrocytes has been investigated using a rapid mixing technique with 3H-labeled pyridoxal. A nonsaturable, initial influx of [3H]pyridoxal into the erythrocyte indicated passive diffusion. Since pyridoxal will form Schiff bases reversibly with amino acids, the possibility of binding to intracellular proteins
L M Henderson, H Mehansho, S L Ink
openaire   +3 more sources

The impact and management of hyperemesis gravidarum: Current and future perspectives

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting in pregnancy affecting around 1%–3% of pregnancies worldwide and is the most common reason for hospital admission in early pregnancy. HG can have lasting consequences for both pregnant individuals and their offspring.
L. M. van der Minnen, I. J. Grooten, C. Dean, J. Trovik, R. C. Painter   +4 more
wiley   +1 more source

Transfer of Sulfur from IscS to IscU during Fe/S Cluster Assembly [PDF]

, 2001
The cysteine desulfurase enzymes NifS and IscS provide sulfur for the biosynthesis of Fe/S proteins. NifU and IscU have been proposed to serve as template or scaffold proteins in the initial Fe/S cluster assembly events, but the mechanism of sulfur ...
Hoff, Kevin G., Silberg, Jonathan J., Urbina, Hugo D., Vickery, Larry E.   +3 more
core   +1 more source

PLP Induced Inhibition of Thymidylate Synthase Activity in T Lymphocytes

European Journal of Inflammation, 2003
The present study was undertaken in order to examine whether pyridoxine may be used as an inhibitor of thymidylate synthase, and thus, as an antiproliferative agent.
M. Palasopoulou, C. Haitoglou, G. Papageorgiou, A. Dimitriadou   +3 more
doaj   +1 more source

Micronutrient deficiencies after pancreatico‐duodenectomy: A narrative review of the literature and recommendations for clinical practice

Nutrition in Clinical Practice, EarlyView.
Abstract Micronutrient uptake is impaired after pancreatico‐duodenectomy (PD) because of malabsorption, reduced absorptive capacity, and poor oral intake. Biochemical depletion is reported in cohort studies, but deficiency states are predominantly reported in case reports, making it difficult to assess occurrence rates.
Mary E. Phillips, Callum Livingstone, Adam E. Frampton, Kathryn H. Hart   +3 more
wiley   +1 more source