Results 1 to 10 of about 54,863 (229)

Facile immobilization of pyridoxal 5′-phosphate using p-diazobenzoyl-derivatized Sepharose 4B [PDF]

Results in Chemistry, 2023
Pyridoxal 5′-phosphate (PLP) is a ubiquitous and versatile cofactor utilized by numerous enzymes involved in amino acid biosynthetic pathways. Immobilized PLP is a valuable tool to isolate unknown PLP-dependent enzymes in nature or to perform in vitro ...
Kun-Hwa Lee, Mark D. Distefano, Burckhard Seelig   +2 more
doaj   +3 more sources

Pyridoxal 5′-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring [PDF]

Environmental Science and Ecotechnology, 2023
Pyridaben (PY) is a widely used organochlorine acaricide, which can be detected in the peripheral blood of pregnant women. Available evidence suggests that PY has reproductive toxicity.
Xingwang Ding, Ya Wen, Xuan Ma, Yuepei Zhang, Yuting Cheng, Zhaofeng Liu, Weiyue Hu, Yankai Xia   +7 more
doaj   +3 more sources

Enzyme-independent catabolism of cysteine with pyridoxal-5′-phosphate [PDF]

Scientific Reports, 2023
Pyridoxal-5′-phosphate (PLP) is a versatile cofactor that assists in different types of enzymatic reactions. PLP has also been reported to react with substrates and catalyze some of these reactions independent of enzymes.
Prajakatta Mulay, Cindy Chen, Vijay Krishna   +2 more
doaj   +2 more sources

SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation [PDF]

Nature Communications
Many essential proteins require pyridoxal 5’-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and ...
Izabella A. Pena, Jeffrey S. Shi, Sarah M. Chang, Jason Yang, Samuel Block, Charles H. Adelmann, Heather R. Keys, Preston Ge, Shveta Bathla, Isabella H. Witham, Grzegorz Sienski, Angus C. Nairn, David M. Sabatini, Caroline A. Lewis, Nora Kory, Matthew G. Vander Heiden, Myriam Heiman   +16 more
doaj   +2 more sources

Case report: Hepatocellular carcinoma in a patient with Pyridoxamine 5-phosphate oxidase (PNPO) deficiency undergoing pyridoxal 5-phosphate (PLP) treatment [PDF]

Molecular Genetics and Metabolism Reports
Pyridoxamine 5-phosphate oxidase (PNPO) deficiency is an autosomal recessive inborn error of metabolism that typically manifests as seizures resistant to conventional anticonvulsants, often presenting in the neonatal period to early infancy.
Jesse Zhen Cheng Lee, Chit Kwong Chow, Cheuk-Wing Fung, Stephen Tak Yau Lui, Suet-Na Sheila Wong   +4 more
doaj   +2 more sources

Complexation of Gold(III) with Pyridoxal 5′-Phosphate-Derived Hydrazones in Aqueous Solution [PDF]

Molecules, 2022
Today, complexes of gold(I) and gold(III) are recognized as promising drugs for the treatment of bacterial infectious diseases and oncological diseases, respectively.
Natalia N. Kuranova, Daniil N. Yarullin, Maksim N. Zavalishin, George A. Gamov   +3 more
doaj   +2 more sources

Association of pyridoxal 5′-phosphate (PLP) with lipid profiles: a population-based cohort study [PDF]

Frontiers in Nutrition
ObjectivesThis study aims to explore the correlation between Pyridoxal 5′-Phosphate (PLP) levels and lipid profiles in adult individuals, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database.MethodsThe research ...
Ru-yang Zhang, Yue Chen, Xin-Qi Yan, Yue Zhang, Hua Zhou, Qian Feng   +5 more
doaj   +2 more sources

yggS Encoding Pyridoxal 5′-Phosphate Binding Protein Is Required for Acidovorax citrulli Virulence [PDF]

Frontiers in Microbiology, 2022
Bacterial fruit blotch, caused by seed-borne pathogen Acidovorax citrulli, poses a serious threat to the production of cucurbits globally. Although the disease can cause substantial economic losses, limited information is available about the molecular ...
Yuanjie Wang, Yuqiang Zhao, Liming Xia, Lin Chen, Yajie Liao, Baohui Chen, Yiyang Liu, Weirong Gong, Yanli Tian, Baishi Hu   +9 more
doaj   +2 more sources

Direct visualization of critical hydrogen atoms in a pyridoxal 5′-phosphate enzyme

Nature Communications, 2017
Pyridoxal 5’-phosphate (PLP) is a ubiquitous co factor for diverse enzymes, among them aspartate aminotransferase. Here the authors use neutron crystallography, which allows the visualization of the positions of hydrogen atoms, and computation to ...
Steven Dajnowicz, Ryne C Johnston, Jerry M Parks   +2 more
exaly   +2 more sources

Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy [PDF]

American Journal of Human Genetics, 2016
Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, functions as a cofactor in humans for more than 140 enzymes, many of which are involved in neurotransmitter synthesis and degradation.
Laurence Prunetti, Ralf A Husain, Matthew P Wilson   +2 more
exaly   +3 more sources