Results 21 to 30 of about 54,863 (229)

4-Phospho-hydroxy-l-threonine is an obligatory intermediate in pyridoxal 5′-phosphate coenzyme biosynthesis inEscherichia coliK-12 [PDF]

FEMS Microbiology Letters, 1996
We show that thrB-encoded homoserine kinase is required for growth of Escherichia coli K-12 pdxB mutants on minimal glucose medium supplemented with 4-hydroxy-L-threonine (synonym, 3-hydroxyhomoserine) or D-glycolaldehyde. This result is consistent with a model in which 4-phospho-hydroxy-L-threonine (synonym, 3-hydroxyhomoserine phosphate), rather than
G, Zhao, M E, Winkler
openaire   +2 more sources

Discovery and Characterization of Pyridoxal 5'-Phosphate-Dependent Cycloleucine Synthases. [PDF]

J Am Chem Soc
Abad AND, Seshadri K, Ohashi M, Delgadillo DA, de Moraes LS, Nagasawa KK, Liu M, Johnson S, Nelson HM, Tang Y.   +9 more
europepmc   +3 more sources

Effectiveness of Pyridoxal-5'-Phosphate in PNPO Deficiency: A Systematic Review. [PDF]

J Inherit Metab Dis
Stolwijk NN, van Dussen L, Reijnhout ND, Brands MMMG, Jaeger B, Clayton PT, Hollak CEM, Bosch AM.   +7 more
europepmc   +3 more sources

Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase. [PDF]

PLoS ONE, 2012
Pyridoxal 5'-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6 ...
Mohini S Ghatge, Roberto Contestabile, Martino L di Salvo, Jigar V Desai, Amit K Gandhi, Christina M Camara, Rita Florio, Isabel N González, Alessia Parroni, Verne Schirch, Martin K Safo   +10 more
doaj   +1 more source

Vitamin B6 Acquisition and Metabolism in Schistosoma mansoni

Frontiers in Immunology, 2021
Schistosomes are parasitic platyhelminths that currently infect >200 million people globally. The adult worms can live within the vasculature of their hosts for many years where they acquire all nutrients necessary for their survival and growth.
Akram A. Da’dara, Manal Elzoheiry, Manal Elzoheiry, Samar N. El-Beshbishi, Patrick J. Skelly   +4 more
doaj   +1 more source

Bioisosteric replacement of pyridoxal-5'-phosphate to pyridoxal-5'-tetrazole targeting Bacillus subtilis GabR. [PDF]

Protein Sci
Kaley NE, Liveris ZJ, Moore M, Reidl CT, Wawrzak Z, Becker DP, Liu D.   +6 more
europepmc   +2 more sources

SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2019
Pyridoxal 5′-phosphate (the active form of vitamin B6) is a cofactor that is important for a broad number of biochemical reactions and is essential for all forms of life.
Michael D. Paxhia, Diana M. Downs
doaj   +1 more source

Competition of Pyridoxal 5'-Phosphate with Ribulose 1,5-Bisphosphate and Effector Sugar Phosphates at the Reaction Centers of the Spinach Ribulose 1,5-Bisphosphate Carboxylase/Oxygenase [PDF]

, 1980
The Stimulation of the carboxylase reaction by effectors of ribulose 1,5-bisphosphate carboxyl­ ase/oxygenase displays higher sensitivity towards pyridoxal 5'-phosphate inhibition than the catalytical process itself. Pyridoxal 5'-phosphate binding to the
Gaudszun, Thomas, Salnikow, Johann, Scharnow, Harald, Vater, Joachim   +3 more
core   +1 more source

Studies on the changes in protein fluorescence and enzymic activity of aspartate aminotransferase on binding of pyridoxal 5'-Phosphate [PDF]

, 1974
1. The a and ,B subforms of aspartate aminotransferase were purified from pig heart. 2. The a subform contained 2mol of pyridoxal 5'-phosphate. The apo-(a subform) could be fully reactived by combination with 2mol of cofactor. 3.
Evans, RW, Holbrook, J
core   +2 more sources

Circulating pyridoxal 5′-phosphate in serum and whole blood: implications for assessment of vitamin B6 status

Journal of Laboratory Medicine, 2023
Concentrations of pyridoxal 5′-phosphate (PLP) in serum and whole blood are routinely measured. The suitability of these markers in capturing vitamin B6 insufficiency is not well studied.
Obeid Rima, Möller Christoph, Geisel Jürgen   +2 more
doaj   +1 more source