Results 51 to 60 of about 54,863 (229)

It takes two to tango: defining an essential second active site in pyridoxal 5'-phosphate synthase. [PDF]

PLoS ONE, 2011
The prevalent de novo biosynthetic pathway of vitamin B6 involves only two enzymes (Pdx1 and Pdx2) that form an ornate multisubunit complex functioning as a glutamine amidotransferase.
Cyril Moccand, Markus Kaufmann, Teresa B Fitzpatrick   +2 more
doaj   +1 more source

Crystal structure of L-aspartate aminotransferase from Schizosaccharomyces pombe.

PLoS ONE, 2019
L-aspartate aminotransferase is a pyridoxal 5'-phosphate-dependent transaminase that catalyzes reversible transfer of an α-amino group from aspartate to α-ketoglutarate or from glutamate to oxaloacetate.
Soo Yeon Jeong, Hyeonseok Jin, Jeong Ho Chang   +2 more
doaj   +1 more source

Structural Basis of the Substrate Specificity and Enzyme Catalysis of a Papaver somniferum Tyrosine Decarboxylase

Frontiers in Molecular Biosciences, 2017
Tyrosine decarboxylase (TyDC), a type II pyridoxal 5′-phosphate decarboxylase, catalyzes the decarboxylation of tyrosine. Due to a generally high sequence identity to other aromatic amino acid decarboxylases (AAADs), primary sequence information is not ...
Huai Guan, Huai Guan, Huai Guan, Shuaibao Song, Shuaibao Song, Shuaibao Song, Howard Robinson, Jing Liang, Haizhen Ding, Jianyong Li, Qian Han, Qian Han, Qian Han   +12 more
doaj   +1 more source

Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]

, 2007
Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma, Kennedy, Charles, Tasker, Paul N., Westfall, Timothy D.   +3 more
core   +1 more source

A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy

BMC Research Notes, 2017
Background The identification of a DNA variant in pyridoxal kinase (Pdxk) associated with increased risk to Parkinson disease (PD) gene led us to study the inhibition of this gene in the Dopa decarboxylase (Ddc)-expressing neurons of the well-studied ...
P. Githure M’Angale, Brian E. Staveley
doaj   +1 more source

Functional Characterization of the Eukaryotic Cysteine Desulfurase Nfs1p from Saccharomyces cerevisiae [PDF]

, 2004
Previous studies have indicated that the essential protein Nfs1 performs a crucial role in cellular iron-sulfur (Fe/S) protein maturation. The protein is located predominantly in mitochondria, yet low amounts are present in cytosol and nucleus.
Balk, Balk, Cupp-Vickery, Diekert, Dutkiewicz, Floss, Frazzon, Frazzon, Garland, Gerber, Gerber, Gietz, Gyula Kispal, Harlow, Hoff, Janneke Balk, Jaschkowitz, Jens T. Kaiser, Kaiser, Kambampati, Kambampati, Katalin Sipos, Kaut, Kim, Kispal, Knight, Knight, Knox, Kolman, Land, Lange, Lange, Lauhon, Leibrecht, Leipuviene, Li, Lill, Matthies, Meyer, Mihara, Mühlenhoff, Mühlenhoff, Mühlenhoff, Nachin, Nadine Richhardt, Nakai, Nakai, Nett, Nilsson, Outten, Papenbrock, Pierrel, Roland Lill, Roy, Sambrook, Schilke, Schwartz, Sherman, Silberg, Sipos, Skovran, Stein, Strain, Takahashi, Tong, Tong, Ulrich Mühlenhoff, Ungermann, Voisine, Wang, Yuvaniyama, Zheng, Zheng, Zheng   +73 more
core   +3 more sources

Cloning and Characterization of Pyridoxal Kinase from Geobacillus sp. H6a

Journal of Pure and Applied Microbiology, 2022
Pyridoxal kinase encoded by pdxK gene, is the important key enzyme in the salvage pathway of vitamin B6 biosynthesis. The enzyme catalyzes the phosphorylation of the 5′ alcohol groups of free form vitamin B6 into their 5′-phosphate forms that requires ...
Jumnong Pasri, Chamaiporn Champasri, Yanee Trongpanich   +2 more
doaj   +1 more source

Synthesis, Structural Characterization, Cytotoxicity, and Antibacterial Properties of Gold(III) Complexes with Hydrazones Derived from Vitamin B₆

Inorganics
The rise in the number of cancer cases and the dissemination of strains with multiple drug resistance in the world pose a serious threat to public health care and human well-being.
Daria V. Petrova, Aleksandra K. Isagulieva, Olga N. Sineva, Vera S. Sadykova, Maksim N. Zavalishin, George A. Gamov   +5 more
doaj   +1 more source

Pharmaceutical compounding of orphan active ingredients in Belgium : how community and hospital pharmacists can address the needs of patients with rare diseases [PDF]

, 2019
Background: Pharmaceutical compounding of orphan active ingredients can offer cost-effective treatment to patients when no other drug product is available for a rare disease or during periods of drug product shortages.
Boussery, Koen, De Spiegeleer, Bart, Peeters, E, Remon, Jean Paul, Van Tongelen, Inge, Vanhoorne, Valérie, Vervaet, Chris, Wynendaele, Evelien   +7 more
core   +2 more sources

The Streptomyces coelicolor small ORF trpM stimulates growth and morphological development and exerts opposite effects on actinorhodin and calcium-dependent antibiotic production [PDF]

, 2020
In actinomycetes, antibiotic production is often associated with a morpho-physiological differentiation program that is regulated by complex molecular and metabolic networks. Many aspects of these regulatory circuits have been already elucidated and many
Alberto Vassallo, Andrea Scaloni, Anna Maria Puglia, Emilia Palazzotto, Giovanni Renzone, Giuseppe Gallo, Luigi Botta, Teresa Faddetta   +7 more
core   +2 more sources