Results 131 to 140 of about 58,002 (312)

The Conserved Family of the Pyridoxal Phosphate-Binding Protein (PLPBP) and Its Cyanobacterial Paradigm PipY. [PDF]

Life (Basel), 2022
Tremiño L, Llop A, Rubio V, Contreras A.   +3 more
europepmc   +1 more source

Asymmetric Synthesis of Atropisomeric Amines via Transaminase‐Catalyzed Dynamic Kinetic Resolution

Advanced Synthesis &Catalysis, Volume 368, Issue 2, January 2026.
A dynamic kinetic resolution approach is developed for the atroposelective synthesis of heterobiaryl primary amines. Using transaminases and leveraging Lewis acid‐base interactions to induce racemization, a variety of axially chiral primary amines are produced in high yields and enantioselectivities.
Juan M. Coto‐Cid, Patricia Rodríguez‐Salamanca, Christian M. Heckmann, Caroline E. Paul, Joaquín López‐Serrano, Rosario Fernández, José M. Lassaletta, Valentín Hornillos, Gonzalo de Gonzalo   +8 more
wiley   +1 more source

Structural and Functional Analysis of the Pyridoxal Phosphate Homeostasis Protein YggS from <i>Fusobacterium nucleatum</i>. [PDF]

Molecules, 2022
He S, Chen Y, Wang L, Bai X, Bu T, Zhang J, Lu M, Ha NC, Quan C, Nam KH, Xu Y.   +10 more
europepmc   +1 more source

Identifying Immune Cells as Mediators in the Impact of Gut Microbiota on Congenital Malformations of the Nervous System

Brain and Behavior, Volume 16, Issue 1, January 2026.
This study reveals causal links between gut microbiota and congenital nervous system malformations, identifying nine immune cell types, such as CD20+ and CD25+ B cells, as mediators, highlighting gut–immune interactions as potential preventive or therapeutic targets.
Haokun Tian, Xiaolan Guo, Jialu Yu, Yuanfang Lu, Wensen Cao, Xiuwei Wang, Zhiqiang Zhu, Zhen Guan, Aiyun Yang, Shen Li, Xiaochun Xu, Caihua Wang, Jianhua Wang   +12 more
wiley   +1 more source

Stereoselective Biocatalytic α‐Deuteration of L‐Amino Acids by a Pyridoxal 5’‐Phosphate‐Dependent Mannich Cyclase [PDF]

, 2023
Jinmin Gao, Chen Zhou, Yang Hai
openalex   +1 more source

Donepezil‐Induced Severe Anorexia and T‐Wave Inversion in Early‐Onset Alzheimer's Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Donepezil hydrochloride, used to treat Alzheimer's disease, is typically initiated at a low dose and titrated to minimize gastrointestinal side effects. Despite its favorable safety profile, the patient developed severe anorexia, dehydration, and electrocardiographic abnormalities.
Nobuyuki Takahashi, Takeshi Kuroda, Takashi Yoshioka, Hidetomo Murakami, Hironori Tanaka   +4 more
wiley   +1 more source

Cooperative effects in the binding of pyridoxal 5′‐phosphate to mitochondrial apo‐aspartate aminotransferase [PDF]

, 1984
Anna Maria Vittoria Garzillo, Gennaro Marino, B. Pispisa   +2 more
openalex   +1 more source

Mannich Reaction With Pyridoxal 5′‐Phosphate Dependent Decarboxylative Aldolase for Synthesis of Noncanonical α‐Amino Acids

ChemistryEurope, Volume 4, Issue 1, January 2026.
The pyridoxal 5′‐phosphate dependent decarboxylative aldolase, UstD was engineered to catalyze a Mannich reaction with cyclic imines. This enzymatic route was applied to synthesize 23 enantioenriched noncanonical amino acids with benzosultam side chains, achieving yields up to 96%, a total turnover number (TTN) of 7500, and excellent stereoselectivity (
Yuqiu Lan, Lingrui Zhang, Keying Yu, Rui Zhang, Cangsong Liao   +4 more
wiley   +1 more source

Parkinson’s Disease: Carbidopa, Nausea, and Dyskinesia [Expression of Concern]

Clinical Pharmacology: Advances and Applications, 2020
Hinz M, Stein A, Cole T. Clin Pharmacol Adv Appl. 2014;6:189–194. The Editor-in-Chief and Publisher of Clinical Pharmacology: Advances and Applications wish to issue an Expression of Concern for the published article.
Hinz M, Stein A, Cole T
doaj  

West Syndrome Is an Exceptional Presentation of Pyridoxine- and Pyridoxal Phosphate-Dependent Epilepsy: Data From a French Cohort and Review of the Literature. [PDF]

Front Pediatr, 2021
Gibaud M, Barth M, Lefranc J, Mention K, Villeneuve N, Schiff M, Maurey H, Barthez MA, Caubel I, Chouchane M, Doummar D, Kossorotoff M, Lamblin MD, Roubertie A, Nabbout R, Van Bogaert P.   +15 more
europepmc   +1 more source