Results 151 to 160 of about 55,337 (248)

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol‐Inspired Approach

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
Hetrombopag targeted PNPO to inhibit multiple myeloma. ABSTRACT Multiple myeloma (MM) is a malignancy of plasma cells whose excessive immunoglobulin production elevates reactive oxygen species (ROS), promoting pathogenesis. Active compounds from Traditional Chinese Medicine, such as celastrol, can exert antitumour effects by further increasing ROS ...
Tianyi Yu, Cheng Wang, Jingru Xie, Yongxin Wei, Hongwei Cui, Huaxia Zhang, Fan Zhou, Zhendong Deng, Ye Yang, Chunyan Gu   +9 more
wiley   +1 more source

The MdICE1/MdFAMA‐MdTYDC Transcriptional Module Confers Cold Tolerance by Regulating Dopamine Metabolism in Apple

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3012-3031, May 2026.
ABSTRACT Low temperature is a critical abiotic stress that imposes major constraints on the sustainable development of the fruit tree industry. Although exogenous dopamine has been shown to enhance cold tolerance in plants, its molecular mechanisms in apple (Malus domestica) remain poorly understood.
Kexin Tan, Xinyang Song, Ziyi Xu, Hongzhen Zhu, Ying Zhang, Shuhan Xu, Zhijun Zhang, Pengmin Li, Fengwang Ma, Chao Li   +9 more
wiley   +1 more source

The C2H2‐GGAT Regulatory Module Fine‐Tunes Glutamate Homeostasis to Improve Fruit Flavour and Enhance Disease Resistance in Peach

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3282-3295, May 2026.
ABSTRACT Free amino acids (FAAs) play a fundamental role in determining fruit quality and stress adaptation, yet their genetic regulation remains poorly understood. Through an integrated approach combining metabolomic and sensory analyses of 120 peach (Prunus persica) hybrids, we identified glutamate as a key metabolite linking FAA content to umami ...
Yike Su, Xiaojuan Yang, Chanyuan Wu, Xianyao Jin, Yuanyuan Zhang, Yuyan Zhang, Kunsong Chen, Mingliang Yu, Bo Zhang   +8 more
wiley   +1 more source

Isolated Kidney Transplant in Primary Hyperoxaluria‐1 Enabled by Small Interfering RNA (siRNA) Therapy. Is It Time for Change? Case Report and Review of the Literature

Pediatric Transplantation, Volume 30, Issue 5, May 2026.
ABSTRACT Background Primary hyperoxaluria type 1 (PH1) is a rare genetic disorder characterized by excessive oxalate production that leads to nephrocalcinosis or nephrolithiasis and progressive kidney failure, associated with systemic oxalosis that is not reversed by dialysis. Pharmacological treatment is limited.
Shameer M. Habeeb, Eva Simkova, Samhar Al‐Akash, Hazem S. Awad, Haneen Yamin, Loai A. Eid, Watfa S. Aldhaheri, Waldo Concepcion, Martin Bitzan   +8 more
wiley   +1 more source

Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes. [PDF]

Nat Chem
Mori T, Moriwaki Y, Sakurada K, Lyu S, Kadlcik S, Janata J, Mazumdar A, Koberska M, Terada T, Kamenik Z, Abe I.   +10 more
europepmc   +1 more source

Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics. [PDF]

Nat Chem, 2018
Hoegl A, Nodwell MB, Kirsch VC, Bach NC, Pfanzelt M, Stahl M, Schneider S, Sieber SA.   +7 more
europepmc   +1 more source

Versatility of Pyridoxal Phosphate as a Coating of Iron Oxide Nanoparticles. [PDF]

Nanomaterials (Basel), 2017
Bonvin D, Aschauer UJ, Bastiaansen JAM, Stuber M, Hofmann H, Mionić Ebersold M.   +5 more
europepmc   +1 more source

CODECARBOXYLASE NOT PYRIDOXAL-3-PHOSPHATE

Journal of Biological Chemistry, 1949
W W, UMBREIT, I C, GUNSALUS
openaire   +2 more sources

Characterization of an <i>Acinetobacter baumannii</i> Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate. [PDF]

Biochemistry
De Vitto H, Belfon KKJ, Sharma N, Toay S, Abendroth J, Dranow DM, Lukacs CM, Choi R, Udell HS, Willis S, Barrera G, Beyer O, Li TD, Hicks KA, Torelli AT, French JB.   +15 more
europepmc   +1 more source

Anti-obesity and hepatoprotective effects of pyridoxal phosphate in rats with metabolic syndrome by raising anti-oxidant potential in both serum and liver tissue, while also decreasing hepatic nuclear factor expression. [PDF]

Iran J Basic Med Sci
Mahdavifard S, Hasani A.
europepmc   +1 more source