The role of pyridoxine as a countermeasure for in-flight loss of lean body mass [PDF]
Ground based and in flight research has shown that humans, under conditions of microgravity, sustain a loss of lean body tissue (protein) and changes in several biological processes including, reductions in red blood cell mass, and neurotransmitters. The
Gilbert, Joyce A.
core +1 more source
A Computational Approach for Identifying Plant-Based Foods for Addressing Vitamin Deficiency Diseases [PDF]
, 2015 Vitamins are nutrients that are essential to human health, and deficiencies have been shown to cause severe diseases. In this study, a computational approach was used to identify vitamin deficiency diseases and plant-based foods with vitamin content ...
Sarkar, Indra Neil, Yu, Christina
core +1 more source
In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes
Chemistry – A European Journal, Volume 31, Issue 29, May 22, 2025.The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer +7 more
wiley +1 more source
Chemoenzymatic Total Synthesis of Lansai B
Chemistry – A European Journal, Volume 31, Issue 26, May 8, 2025.Lansai B was obtained in a chemoenzymatic approach from the small building block 5‐bromoindole utilizing two enzymes. Applying a tryptophan synthase and a further characterized C3‐methyltransferase the sterically demanding framework is constructed within just six steps. After late‐stage Suzuki‐coupling and n‐methylation the natural product was isolated.
Marcel Schatton +5 more
wiley +1 more source
Epilepsy due to PNPO mutations: genotype, environment and treatment affect presentation and outcome [PDF]
, 2017 Mutations in PNPO are a known cause of neonatal onset seizures that are resistant to pyridoxine but responsive to pyridoxal phosphate (PLP). Mills etal. show that PNPO mutations can also cause neonatal onset seizures that respond to pyridoxine but worsen
Bala, Pronab +25 more
core
Coenzymatic activity of homologues of pyridoxal phosphate.
, 1967 Yoshimasa Morino, Esmond E. Snell
openalex +1 more source
Pyridoxal-5′-phosphate-dependent catalytic antibodies [PDF]
, 2018 Cofactors—i.e., metal ions and coenzymes—extend the catalytic scope of enzymes and might have been among the first biological catalysts. They may be expected to efficiently extend the catalytic potential of antibodies.
Christen, Philipp, Gramatikova, Svetlana
core
Vitamin B6-dependent epilepsy due to pyridoxal phosphate-binding protein (PLPBP) defect - First case report from Pakistan and review of literature. [PDF]
Ann Med Surg (Lond), 2020 Ahmed S +3 more
europepmc +1 more source
Some remarks regarding the manometric determination of pyridoxal phosphate [PDF]
, 1964 Th.W. Donkerlo
openalex +1 more source