Results 41 to 50 of about 40,643 (298)
Angewandte Chemie, EarlyView.A reaction starting from two amino acids, phosphoserine and Gly, reveals a pathway to the α‐keto acid building blocks pyruvate and glyoxylate, key components of a plausible early metabolic system. A one‐pot β‐elimination and transamination sequence also initiates a cascade of protometabolic transformations that provide crucial insights into the ...
Louis M.P. Ter‐Ovanessian +5 more
wiley +2 more sources
PLP Induced Inhibition of Thymidylate Synthase Activity in T Lymphocytes
European Journal of Inflammation, 2003 The present study was undertaken in order to examine whether pyridoxine may be used as an inhibitor of thymidylate synthase, and thus, as an antiproliferative agent.
M. Palasopoulou +3 more
doaj +1 more source
The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters [PDF]
, 2014 The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitochondrial carrier family, many of which have been shown to transport inorganic anions, amino acids, carboxylates, nucleotides, and coenzymes across the inner
Agrimi, G. +6 more
core +2 more sources
Ancient and recent collisions revealed by phosphate minerals in the Chelyabinsk meteorite [PDF]
arXiv, 2021 The collision history of asteroids is an important archive of inner Solar System evolution. Evidence for these collisions is brought to Earth by meteorites, which can preserve impact-reset radioisotope mineral ages. However, as meteorites often preserve numerous mineral ages, their interpretation is controversial. Here, we combine analysis of phosphate
arxiv
Contact Ion Pairs of Phosphate Groups in Water -- Two-Dimensional Infrared Spectroscopy of Dimethyl-Phosphate and Ab-Initio Simulations [PDF]
J. Phys. Chem. Lett. 2019, 10, 6281-6286, 2019 The interaction of phosphate groups with ions in an aqueous environment has a strong impact on the structure and folding processes of DNA and RNA. The dynamic variety of ionic arrangements, including both contact pairs and water separated ions, and the molecular coupling mechanisms are far from being understood.
arxiv +1 more source
Sugar and chromosome stability: Clastogenic effects of sugars in vitamin B6-deficient cells [PDF]
, 2014 Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, has been implicated in preventing human pathologies, such as diabetes and cancer. However, the mechanisms underlying the beneficial effects of PLP are still unclear. Using Drosophila as a model
Gatti, Maurizio +3 more
core +3 more sources
Labeling of hemoglobin with pyridoxal phosphate.
Journal of Biological Chemistry, 1982 The reaction of pyridoxal 5'-phosphate (PLP) with deoxyhemoglobin is confined to 2 residues in the beta chains, i.e. the alpha-amino group of valine 1 and the epsilon-amino group of lysine 82, both of which are located in the polyphosphate binding site.
James M. Manning +4 more
openaire +3 more sources
Acta Pharmaceutica, 2019 With the increased number of multi-drug formulations, there is a need to develop new methods for simultaneous determinations of drugs. A precise, accurate and reliable liquid chromatographic method was developed for simultaneous determination of ...
Ali Amir +6 more
doaj +1 more source
Pyridoxal Phosphate vs Pyridoxine for Intractable Seizures
Pediatric Neurology Briefs, 2005 The efficacy of pyridoxal phosphate (PLP) compared to pyridoxine (PN) in the control of idiopathic intractable epilepsy was studied in 94 children, aged 8 months to 15 years, at the National Taiwan University Hospital, Taipei, Taiwan.
J Gordon Millichap
doaj +1 more source
Binding Group of Oligonucleotides on TiO 2 Surfaces: Phosphate Anions or Nucleobases? [PDF]
, 2021 Although the immobilization of oligonucleotides (nucleic acid) on mineral surfaces is at the basis of different biotechnological applications, an atomistic understanding of the interaction of the nucleic acid components with the titanium dioxide surfaces has not yet been achieved.
arxiv +1 more source