Results 81 to 90 of about 661,688 (260)

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

The FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.‐J. Lievens, Mariarita Bertoldi   +11 more
wiley   +1 more source

Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation.

Nutrition reviews, 2013
A variety of inflammatory disease conditions have been found to be associated with low levels of plasma pyridoxal 5'-phosphate (PLP), the active form of vitamin B6 , without any indication of a lower dietary intake of vitamin B6 , excessive catabolism of
L. Paul, P. Ueland, J. Selhub
semanticscholar   +1 more source

Dietary Phosphorus Requirement for Tambaqui, Colossoma macropomum, in the Grow‐Out Phase

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Phosphorus is essential for fish growth as it is crucial in skeletal development and metabolic reactions. The dietary requirement for this mineral varies among fish species and growth stages. Therefore, the objective of this study was to determine the available phosphorus (AP) requirement for tambaqui during the grow‐out phase (± 400 to 1000 g)
Ludmila L. C. Menezes, Vânia M. Machado, Cristielle N. Souto, Danilo C. Proença, Guilherme W. Bueno, Igo G. Guimarães   +5 more
wiley   +1 more source

The Landscape of Cancer Metabolism as a Therapeutic Target

Pathology International, EarlyView.
ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley   +1 more source

The Influence of Ethanolic Extract of Hypericum Perforatum (St. John's wort) on Growth Performance, Serum Metabolites, Fat Deposition, Immunity, and Lipid Peroxidation in Broiler Chickens

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
ABSTRACT Background Having bioactive components such as hypericin, hyperforin and quercetin has enabled Hypericum perforatum (HP) to show antioxidant, antiviral and hypocholesterolemic effects in different animal species. Objectives This study aimed to investigate the effects of different levels of Hypericum perforatum extract (HPE) additions on ...
Mohammad Ali Behroozilak, Seyed Adel Moftakharzadeh, Morteza Behroozlak, Vahid Vahedi, Somayeh Bakhshalizadeh   +4 more
wiley   +1 more source

THE INTERACTION OF PYRIDOXAL PHOSPHATE WITH ALCOHOL DEHYDROGENASE

THE JOURNAL OF VITAMINOLOGY, 1967
The interaction of PAL-P with ADH in vitro was observed, and electrophoretic mobility and absorption spectrum also changed. The molar ratios (PAL-P:ADH) of PAL-P-ADH complex was about 1:9.
Kozo Yamada, Shunji Sawaki, Hisaoki Hattori   +2 more
openaire   +4 more sources

Reconstitution of the pyridoxal 5'-phosphate (PLP) dependent enzyme serine palmitoyltransferase (SPT) with pyridoxal reveals a crucial role for the phosphate during catalysis.

Chemical Communications, 2013
The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) is required for de novo sphingolipid biosynthesis. A previous study revealed a novel and unexpected interaction between the hydroxyl group of the l-serine substrate and ...
A. E. Beattie, D. Clarke, J. M. Wadsworth, J. Lowther, Hochul Sin, D. Campopiano   +5 more
semanticscholar   +1 more source

Features and Prognosis of Patients With Retroperitoneal Fibrosis Developing Fibrosing Mediastinitis: Case‐Control Study and Systematic Review

ACR Open Rheumatology, Volume 7, Issue 8, August 2025.
Objective Retroperitoneal fibrosis (RPF) complicated by mediastinal fibrosis (MF) is rare but fatal. We aimed to explore the features and indicators of poor prognosis for the population of those affected. Methods Patients with idiopathic RPF were recruited in Peking University International Hospital.
Yishan Ding, Zhiyan Li, Shibo Liu, Mei Li, Yubo Ren, Kai‐Feng Xu, Chenghua Luo, Cuiping Pan, Hui Gao   +8 more
wiley   +1 more source

Parkinson’s Disease: Carbidopa, Nausea, and Dyskinesia [Retraction]

Clinical Pharmacology: Advances and Applications, 2021
Hinz M, Stein A, Cole T. Clin Pharmacol. 2014;6:189–194.The Editor-in-chief and Publisher of Clinical Pharmacology: Advances and Applications wish to retract the published article.This perspective article cites several original ...
Hinz M, Stein A, Cole T
doaj  

A loss of Pdxk model of Parkinson disease in Drosophila can be suppressed by Buffy

BMC Research Notes, 2017
Background The identification of a DNA variant in pyridoxal kinase (Pdxk) associated with increased risk to Parkinson disease (PD) gene led us to study the inhibition of this gene in the Dopa decarboxylase (Ddc)-expressing neurons of the well-studied ...
P. Githure M’Angale, Brian E. Staveley
doaj   +1 more source