Results 81 to 90 of about 40,643 (298)

Pyridoxine Responsiveness and PNPO Gene Mutations

open access: yesPediatric Neurology Briefs, 2014
Investigators at University Hospital, Zurich, Switzerland, and multiple centers in Europe and Canada, sequenced the pyridoxal 5-phosphate oxidase (PNPO) gene in 31 patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin ...
J Gordon Millichap, John J Millichap
doaj   +1 more source

Magnetic anisotropy in Li-phosphates and origin of magnetoelectricity in LiNiPO4 [PDF]

open access: yes, 2009
Li-based phosphates are paradigmatic materials for magnetoelectricity. By means of first-principles calculations, we elucidate the microscopic origin of spin anisotropy and of magnetoelectric effects in LiNiPO4. The comparison with LiCoPO4 reveals that Co-d7 and Ni-d8 electronic clouds show distinct orbital shapes, which in turn result in an opposite ...
arxiv   +1 more source

Online monitored characterization of Phocaeicola vulgatus for organic acid production using anaerobic microtiter plate cultivations

open access: yesBiotechnology Progress, Volume 41, Issue 2, March/April 2025.
Abstract Phocaeicola vulgatus (formerly Bacteroides vulgatus), an anaerobic gut bacterium, produces several organic acids. Research on P. vulgatus is still in its infancy. However, a detailed understanding of P. vulgatus growth and metabolism is essential for its assessment as an organic acid producer.
Laura Keitel   +4 more
wiley   +1 more source

Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses

open access: yesFrontiers in Immunology, 2022
Targeting T cell metabolism is an established method of immunomodulation. Following activation, T cells engage distinct metabolic programs leading to the uptake and processing of nutrients that determine cell proliferation and differentiation ...
David Bargiela   +10 more
doaj   +1 more source

Microtextures in the Chelyabinsk impact breccia reveal the history of Phosphorus-Olivine-Assemblages in chondrites [PDF]

open access: yes, 2020
The geochemistry and textural associations of chondritic phosphate minerals can provide insights into the geological histories of parental asteroids, but the processes governing their formation and deformation remain poorly constrained. Here, we present a quantitative assessment of phosphorus-bearing mineral textures in the three variously-shocked ...
arxiv   +1 more source

Biomedical aspects of pyridoxal 5 -phosphate availability [PDF]

open access: yes, 2012
The biologically active form of vitamin B6, pyridoxal 5'-phosphate (PLP), is a cofactor in over 160 enzyme activities involved in a number of metabolic pathways, including neurotransmitter synthesis and degradation.
Di Salvo, M. L.   +2 more
core   +1 more source

Exploring the Stability and Substrate Profile of Transaminase from Silicibacter pomeroyi with Ancestral Sequence Reconstruction

open access: yesChemBioChem, EarlyView.
This study describes the successful identification of ancestral sequences N50 and N49, which have a longer half‐life of approximately four and two times the wild‐type Sp‐amine transaminase, respectively.. This approach effectively enhances the thermal stability of the transaminase.
Luyao Zhao   +4 more
wiley   +1 more source

Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5′-phosphate as the inhibitor

open access: yesJournal of Lipid Research, 2006
Peroxidized phospholipid-mediated cytotoxity is involved in the pathophysiology of a number of diseases [i.e., the abnormal increase of phosphatidylcholine hydroperoxide (PCOOH) found in the plasma of type 2 diabetic patients]. The PCOOH accumulation may
Ohki Higuchi   +5 more
doaj  

Variable treatment response in a patient with pyridoxal N phosphate oxidase (PNPO) deficiency- understanding the paradox

open access: yesEpilepsy & Behavior Reports, 2020
A 6-year-old girl presented with history of infantile onset epileptic encephalopathy and developmental delay. She had polymorphic seizures that were refractory to regular anti-seizure medication.
Smilu Mohanlal   +3 more
doaj  

Ornithine decarboxylase activity, a clinical biomarker for evaluating cancer chemopreventive efficacy of phytomolecules [PDF]

open access: yes, 2011
Biomarkers of cancer have made a strong traipse in predicting the disease pattern and contributed significantly to the understanding of tumour state, progression, characteristics and response to therapies.
Nusrat Masood   +2 more
core   +2 more sources

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