Results 181 to 190 of about 4,298 (230)

Dendrimeric Pyridoxamine Enzyme Mimics

Journal of the American Chemical Society, 2003
PAMAM dendrimers from generations 1-6 were synthesized with pyridoxamine in their core. They transaminated pyruvic and phenylpyruvic acids in water to alanine and phenylalanine, respectively, with Michaelis-Menten kinetics and high effectiveness compared with simple pyridoxamine.
Lei, Liu, Ronald, Breslow
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Two homogeneous immunoassays for pyridoxamine

Journal of Immunological Methods, 1985
Protein conjugates of pyridoxal have been used to elicit anti-vitamin B6 antibodies in rabbits. These antibodies have been incorporated into 2 homogeneous assays systems, a spin immunoassay, using a paramagnetic derivative of the vitamin as ligand, and a fluorescence enzyme immunoassay, using beta-galactosidase conjugated to vitamin B6 as the indicator
D L, Brandon, J W, Corse, J J, Windle, L L, Layton   +3 more
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Synthese des Pyridoxamin‐5′‐triphosphorsäureesters und Pyridoxamin‐5′‐monophosphorsäureesters

Helvetica Chimica Acta, 1951
AbstractAus Pyridoxamin wurde durch Einwirkung von meta‐Phosphorsäure in der Wärme der Pyridoxamin‐5′‐triphosphorsäureester erhalten, der beim Erhitzen in Wasser 2 Mol H3PO4 verliert und in Pyridoxamin‐5′‐monophosphat übergeht. Pyridoxamin‐5′‐monophosphat wurde einerseits als phosphorsaures und chlorwasserstoffsaures Salz, andererseits als Calciumsalz ...
M. Viscontini, C. Ebnöther, P. Karrer
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Pyridoxamine Protects Proteins from Functional Damage by 3-Deoxyglucosone:  Mechanism of Action of Pyridoxamine

Biochemistry, 2007
Pyridoxamine (PM) is a promising drug candidate for treatment of diabetic nephropathy. The therapeutic effect of PM has been demonstrated in multiple animal models of diabetes and in phase II clinical trials. However, the mechanism of PM therapeutic action is poorly understood.
Sergei V, Chetyrkin, Wenhui, Zhang, Billy G, Hudson, Anthony S, Serianni, Paul A, Voziyan   +4 more
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Enzymatic transamination of pyridoxamine in tobacco plants

Plant Science, 2013
Vitamin B6 (VB6) comprises a group of pyridine compounds that are involved in a surprisingly high diversity of biochemical reactions. Humans and animals depend largely on plants for their VB6 nutrition. Many studies have focused on biosynthesis of VB6 and comparatively little is known about VB6 metabolic conversion in plants.
ShuoHao, Huang, JianYun, Zhang, Mei, Wu, Qiong, Wu, LongQuan, Huang   +4 more
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A Potent Polymer/Pyridoxamine Enzyme Mimic

Journal of the American Chemical Society, 2002
An enzyme mimic consisting of pyridoxamines covalently linked to polyethyleneimine carrying long-chain alkyl groups converts pyruvic acid to dl-alanine with as much as an 8000-fold acceleration relative to the reaction with simple pyridoxamine at the same pyridoxamine concentration.
Lei, Liu, Ronald, Breslow
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Isolation and Structural Characterization of Acrylamide−Pyridoxamine Adducts

Chemical Research in Toxicology, 2011
Pyridoxamine (PM) is an effective inhibitor of the formation of the carcinogen acrylamide (AA) from its precursors in low-moisture model systems. Although AA is widely assumed to act by scavenging carbonyl compounds, no alternative pathways have to date been explored.
Arribas Lorenzo, Gema, Pintado-Sierra, Mercedes, Morales, F. J.   +2 more
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The occurrence of pyridoxamine phosphate in milk

Journal of Dairy Research, 1961
SummaryThe presence of pyridoxamine phosphate in extracts of freeze-dried raw and evaporated milks has been demonstrated by separation and identification of the vitamin B6 active compounds by chromatography and electrophoresis on paper. Its presence in the milk extracts is the cause of the higher values for vitamin B6 activity measured with ...
Margaret E. Gregory, L. A. Mabbitt
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Pyridoxamine, a scavenger agent of carbohydrates

International Journal of Chemical Kinetics, 2007
AbstractPyridoxamine has been found to inhibit protein glycation and to avoid the formation of advanced glycation end‐products (AGEs). One of the mechanisms by which pyridoxamine can inhibit glycation involves the scavenger of carbonyl groups with glycation capacity.
Miquel Adrover, Bartolomé Vilanova, Francisco Muñoz, Josefa Donoso   +3 more
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Pyridoxamine (BioStratum).

Current opinion in investigational drugs (London, England : 2000), 2005
BioStratum is developing pyridoxamine (Pyridorin), an advanced glycation end-product (AGE) inhibitor, for the potential prevention of diabetic nephropathy. By January 2004, phase II trials had been completed.
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