Results 71 to 80 of about 11,107 (336)
CellsDoxorubicin (DOX) is commonly used in cancer treatment but associated with cardiotoxicity. Pyridoxamine (PM), a vitamin B6 derivative, could be a cardioprotectant.
Sibren Haesen +5 more
doaj +1 more source
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
Reduction of advanced-glycation end products levels and inhibition of RAGE signaling decreases rat vascular calcification induced by diabetes. [PDF]
PLoS ONE, 2014 Advanced-glycation end products (AGEs) were recently implicated in vascular calcification, through a process mediated by RAGE (receptor for AGEs). Although a correlation between AGEs levels and vascular calcification was established, there is no evidence
Mathieu R Brodeur +6 more
doaj +1 more source
Metabolite biomarker discovery for metabolic diseases by flux analysis [PDF]
, 2012 Metabolites can serve as biomarkers and their identification has significant importance in the study of biochemical reaction and signalling networks.
Ching, WK +3 more
core +1 more source
Pyridoxamine, Advanced Glycation Inhibition, and Diabetic Nephropathy [PDF]
Journal of the American Society of Nephrology, 2012 Diabetic nephropathy remains the most common cause of ESRD, accounting for more than 40% of patients treated with dialysis. The standard therapy for diabetic nephropathy consists of early detection, aggressive glycemic control, and treatment of hypertension and proteinuria using renin ...
Joline L T, Chen, Jean, Francis
openaire +2 more sources
Scientific Reports, 2017 In this study we investigate pyridoxamine (PM) and/or sulforaphane (SFN) as therapeutic interventions to determine whether activators of NFE2-related factor 2 (Nrf2) can be used in addition with inhibitors of advanced glycation end products (AGE ...
A. Pereira +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.In the H‐type electrolytic cell, carbon dioxide is reduced to acetic acid via electro‐microbial catalysis. The simply processed acetic acid is further converted through biological fermentation into high‐value‐added products, including acrylic acid, L‐lactic acid, and β‐alanine.
Kaixing Xiao +8 more
wiley +1 more source
A Computational Approach for Identifying Plant-Based Foods for Addressing Vitamin Deficiency Diseases [PDF]
, 2015 Vitamins are nutrients that are essential to human health, and deficiencies have been shown to cause severe diseases. In this study, a computational approach was used to identify vitamin deficiency diseases and plant-based foods with vitamin content ...
Sarkar, Indra Neil, Yu, Christina
core +1 more source
Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity. [PDF]
PLoS ONE, 2011 Despite intensive effort, the majority of the annotated Mycobacterium tuberculosis genome consists of genes encoding proteins of unknown or poorly understood function.
Ellene H Mashalidis +6 more
doaj +1 more source
Pyridoxamine protects protein backbone from oxidative fragmentation [PDF]
Biochemical and Biophysical Research Communications, 2011 Oxidative damage to proteins is one of the major pathogenic mechanisms in many chronic diseases. Therefore, inhibition of this oxidative damage can be an important part of therapeutic strategies. Pyridoxamine (PM), a prospective drug for treatment of diabetic nephropathy, has been previously shown to inhibit several oxidative and glycoxidative pathways,
Sergei, Chetyrkin +5 more
openaire +2 more sources