Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB
Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1268-1276, July 2025.Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang +9 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2057-2069, July 2025.Abstract Aims In a large cohort of hospitalized patients, previously validated physiologically based pharmacokinetic (PBPK)‐based models for apixaban and rivaroxaban are being assessed for their performance in predicting individual pharmacokinetics, aiming to identify patients at high risk of under‐ or overdosing based on demographic, physiological and
Frédéric Gaspar +12 more
wiley +1 more source
Kynurenine pathway metabolites in Alzheimer's disease. [PDF]
, 2017 Background Metabolites of tryptophan, produced via the kynurenine pathway (kynurenines) have been linked to Alzheimer’s disease (AD) in small cohorts with conflicting results.
Advani, R +6 more
core +2 more sources
Experimental Biology and Medicine, 1949 SummaryThe known metabolic products of vitamin B6—pyridoxal, pyridoxamine, pyridoxine and pyridoxic acid—were measured in normal human urine and in the urine of human subjects each fed one of the 3 forms of the vitamin.The chief product found, regardless of the form fed, was pyridoxic acid.
J C, RABINWITZ, E E, SNELL
openaire +2 more sources
Catalytic Activities of Pyridoxal Analogues. I. The Catalytic Effects of Pyridoxal, Pyridoxal Methochloride, and Pyridoxal N-Oxide on the Racemization of
Bulletin of the Chemical Society of Japan, 1975 Abstract An improved method for the syntheses of pyridoxal methochloride (1) and pyridoxal N-oxide (5) was investigated. Further, the catalytic activities of pyridoxal, 1, and 5 on the racemization of l-glutamic acid in the presence of cupric ions were studied.
Makoto Ando, Sakae Emoto
openaire +1 more source
Food Science &Nutrition, Volume 13, Issue 5, May 2025.A significant improvement in hormonal and oxidative stress biomarkers was observed in rats treated with Amaranthus spinosus, especially at high doses, after induction of ovarian hyperthecosis. Amaranthus spinosus could be a management approach for ovarian hyperthecosis via regulating circRNA (hsa‐circ‐0001577), disturbed hormonal balance, and ...
Naglaa M. Ammar +9 more
wiley +1 more source
Riktad metabolomik med 'Ultra Performans' Vätskekormatografi Mass Spekrometri (UPLC-MS) visar metaboliska skillnader i hälsosamma samt atopiska Staffordshire bullterrier efter två olika dieter : en pilotstudie [PDF]
, 2021 While anecdotal evidence has long claimed that a raw meat–based diet (RMBD) improves the metabolic health of canines, no rigorous scientific study has clarified this issue.
Moore, Robin
core
Comprehensive and quantitative profiling of B vitamins and related compounds in the mammalian liver [PDF]
, 2020 A method for the simultaneous quantification of B vitamins and related amines in one-carbon (1C) metabolism would benefit the study of diet and genetic/epigenetic regulation of mammalian development and health.
Barrett, David +4 more
core +2 more sources
Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics [PDF]
, 2017 Adverse reactions or lack of response to medications are important concerns for drug development programs. However, faithful predictions of drug metabolism and toxicity are difficult because animal models show only limited translatability to humans ...
Beck, Olof +7 more
core +1 more source
Reaction of pyridoxal-5′-phosphate with γ-carboxyglutamic acid [PDF]
Experientia, 1980 Pyridoxal-5′-phosphate (PLP) reacts with γ-carboxyglutamic acid (Gla) to form a stable complex absorbing at 325 nm. It is suggested that a condensation occurs in which the formyl group of PLP reacts with the α-amino group and the γ carbon atom of Gla to give a pyrrolidine derivative.
Laura Pecci +3 more
openaire +1 more source