Results 101 to 110 of about 6,229 (253)

Dietary supplementation with milk‐derived Bifidobacterium animalis subsp. lactis relieves colitis‐linked reproductive disorders via gut‐testis axis

iMetaOmics, Volume 2, Issue 1, March 2025.
The illustration of health benefits of Bifidobacterium animalis subsp. lactis NJ241 isolated from naturally fermented bovine milk. Integrative approaches unraveled that daily supplementation with Bifidobacterium animalis subsp. lactis NJ241 could markedly suppress colitis‐linked reproductive disorders through the gut‐testis axis.
Jingmin Lin, Lingzi Yin, Yueyao Fan, Zhiling Yu, Xin Ma, Xiuqiong Fu, Yong Zhang, Shaojun Tang, Jiali Chen   +8 more
wiley   +1 more source

Metabolomics and Microbiomics Insights into Differential Surface Fouling of Three Macroalgal Species of Fucus (Fucales, Phaeophyceae) That Co-Exist in the German Baltic Sea

Marine Drugs, 2023
The brown algal genus Fucus provides essential ecosystem services crucial for marine environments. Macroalgae (seaweeds) release dissolved organic matter, hence, are under strong settlement pressure from micro- and macrofoulers.
Ernest Oppong-Danquah, Martina Blümel, Deniz Tasdemir   +2 more
doaj   +1 more source

Large presence of carbonic acid in CO$_2$-rich aqueous fluids under Earth's mantle conditions [PDF]

Journal of Physical Chemistry Letters 10, 5135-5141 (2019), 2019
The chemistry of carbon in aqueous fluids at extreme pressure and temperature conditions is of great importance to Earth's deep carbon cycle, which substantially affects the carbon budget at Earth's surface and global climate change. At ambient conditions, the concentration of carbonic acid in water is negligible, so aqueous carbonic acid was simply ...
arxiv   +1 more source

SYISL Knockout Promotes Embryonic Muscle Development of Offspring by Modulating Maternal Gut Microbiota and Fetal Myogenic Cell Dynamics

Advanced Science, Volume 12, Issue 6, February 10, 2025.
SYISL knockout significantly promotes embryonic muscle development and increases muscle fiber numbers of offspring by modulating maternal gut microbiota composition and butyrate‐HDAC‐H3K9ac/H3K27ac pathway. Furthermore, scRNA‐seq analysis shows that SYISL knockout alone significantly increases the number and proportion of myogenic cells and their ...
Hao Zuo, Wei Jiang, Jianwei Gao, Zhibo Ma, Chen Li, Yaxin Peng, Jianjun Jin, Xizhen Zhan, Wei Lv, Xiao Liu, Jingjing Hu, Mengdi Zhang, Yiming Jia, Zaiyan Xu, Junming Tang, Rong Zheng, Bo Zuo   +16 more
wiley   +1 more source

Carbon Doping of MgB2 by Toluene and Malic-Acid-in-Toluene [PDF]

, 2010
The decomposition of malic acid in the presence of Mg and B was studied using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA) which revealed that malic acid reacted with Mg but not B. Also, the addition of toluene to dissolve malic acid followed by subsequent drying resulted in no reaction with Mg, indicating that the malic
arxiv   +1 more source

THE TRYPTOPHAN LOAD AS A TEST FOR PYRIDOXINE DEFICIENCY IN HOSPITALIZED PATIENTS * [PDF]

, 1969
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73697/1/j.1749-6632.1969.tb54253.x ...
Coon, William W., Nagler, Emily
core   +1 more source

Utility of Biomarker‐Informed Drug Interaction Evaluation in Drug Development and Regulatory Decision Making

Clinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 398-402, February 2025.
The measurement of endogenous biomarkers in plasma and urine before and after administration of an investigational drug in a clinical study may provide an early indication of its drug–drug interaction (DDI) potential via a specific pathway. In the first international harmonized guideline on drug interaction studies, the International Council for ...
Akihiro Ishiguro, Hiroyuki Kusuhara, Emi Kimoto, So Miyoshi, Katsuhiko Mizuno, Motohiro Hoshino, Hiroshi Suzuki   +6 more
wiley   +1 more source

Expanding Role of Endogenous Biomarkers for Assessment of Transporter Activity in Drug Development: Current Applications and Future Horizon

Pharmaceutics
The evaluation of transporter-mediated drug–drug interactions (DDIs) during drug development and post-approval contributes to benefit–risk assessment and helps formulate clinical management strategies.
Vikram Arya, Joseph D. Ma, Kine Eide Kvitne   +2 more
doaj   +1 more source

A search for mid-IR bands of amino acids in the Perseus Molecular Cloud [PDF]

arXiv, 2021
Amino acids are building-blocks of proteins, basic constituents of all organisms and essential to life on Earth. They are present in carbonaceous chondrite meteorites and comets, but their origin is still unknown. Formation of amino acids in the interstellar medium is posible via specific gas-phase reactions in dark clouds, however sensitive ...
arxiv  

Effects of Cimetidine and Dolutegravir on the Endogenous Drug–Drug Interaction Biomarkers for Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Protein 1 in Healthy Volunteers

Clinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 523-533, February 2025.
This study was designed to assess the quantitative performance of endogenous drug–drug interaction (DDI) biomarkers (N1‐methylnicotinamide (1‐NMN), N1‐methyladenosine (m1A), and creatinine) for the organic cation transporters, OCT2 and MATE1/2K in the kidney.
Tomoki Koishikawa, Kaku Fujiwara, Kunal Taskar, Maciej J. Zamek‐Gliszczynski, Kenta Yoshida, Xiaoyan Chu, Hideki Hirabayashi, Jialin Mao, Kevin Rockich, Tadayuki Takashima, Yoshiyuki Yamaura, Yurong Lai, Yukana Tomoda, Tomoko Kito, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara   +17 more
wiley   +1 more source