Results 71 to 80 of about 5,110,049 (220)
Effectiveness of Pyridoxal‐5′‐Phosphate in PNPO Deficiency: A Systematic Review
Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.ABSTRACT Pyridox(am)ine 5′‐phosphate oxidase (PNPO) deficiency is an ultrarare inherited neurometabolic disease, characterized by primarily neonatal‐onset B6‐responsive epileptic encephalopathies. Treatment often requires sustainable access to high‐quality pyridoxal‐5′‐phosphate (PLP, i.e., active vitamin B6), although some patients (also) respond to ...
Nina N. Stolwijk +7 more
wiley +1 more source
Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics
Metabolism Open, 2021 Background: Alzheimer's Disease (AD) is a complex and multifactorial disease and novel approaches are needed to illuminate the underlying pathology. Metabolites comprise the end-product of genes, transcripts, and protein regulations and might reflect ...
Jonas Ellegaard Nielsen +7 more
doaj +1 more source
Multi‐omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development
Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.This finding could lead to clinical diagnosis of CA severity and provide new treatment strategies. A novel panel composed of five metabolites can be used to accurately diagnose the development of CA. Abstract Background Coronary atherosclerosis (CA) is a leading cause of cardiovascular diseases with the high morbidity and mortality; however, the ...
Mengxue He +10 more
wiley +1 more source
PharmaceuticsThe evaluation of transporter-mediated drug–drug interactions (DDIs) during drug development and post-approval contributes to benefit–risk assessment and helps formulate clinical management strategies.
Vikram Arya +2 more
doaj +1 more source
Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB
Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1268-1276, July 2025.Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang +9 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2057-2069, July 2025.Abstract Aims In a large cohort of hospitalized patients, previously validated physiologically based pharmacokinetic (PBPK)‐based models for apixaban and rivaroxaban are being assessed for their performance in predicting individual pharmacokinetics, aiming to identify patients at high risk of under‐ or overdosing based on demographic, physiological and
Frédéric Gaspar +12 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 5, May 2025.A significant improvement in hormonal and oxidative stress biomarkers was observed in rats treated with Amaranthus spinosus, especially at high doses, after induction of ovarian hyperthecosis. Amaranthus spinosus could be a management approach for ovarian hyperthecosis via regulating circRNA (hsa‐circ‐0001577), disturbed hormonal balance, and ...
Naglaa M. Ammar +9 more
wiley +1 more source
Catalytic Activities of Pyridoxal Analogues. I. The Catalytic Effects of Pyridoxal, Pyridoxal Methochloride, and Pyridoxal N-Oxide on the Racemization of
Bulletin of the Chemical Society of Japan, 1975 Abstract An improved method for the syntheses of pyridoxal methochloride (1) and pyridoxal N-oxide (5) was investigated. Further, the catalytic activities of pyridoxal, 1, and 5 on the racemization of l-glutamic acid in the presence of cupric ions were studied.
Makoto Ando, Sakae Emoto
openaire +1 more source
Translational Psychiatry, 2023 Human brain development starts in the embryonic period. Maternal preconception nutrition and nutrient availability to the embryo may influence brain development at this critical period following conception and early cellular differentiation, thereby ...
Jian Huang +14 more
doaj +1 more source
Reaction of pyridoxal-5′-phosphate with γ-carboxyglutamic acid [PDF]
Experientia, 1980 Pyridoxal-5′-phosphate (PLP) reacts with γ-carboxyglutamic acid (Gla) to form a stable complex absorbing at 325 nm. It is suggested that a condensation occurs in which the formyl group of PLP reacts with the α-amino group and the γ carbon atom of Gla to give a pyrrolidine derivative.
Laura Pecci +3 more
openaire +1 more source