Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]
arXiv, 2023 Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv
Riktad metabolomik med 'Ultra Performans' Vätskekormatografi Mass Spekrometri (UPLC-MS) visar metaboliska skillnader i hälsosamma samt atopiska Staffordshire bullterrier efter två olika dieter : en pilotstudie [PDF]
, 2021 While anecdotal evidence has long claimed that a raw meat–based diet (RMBD) improves the metabolic health of canines, no rigorous scientific study has clarified this issue.
Moore, Robin
core
Journal of Nutritional Science and Vitaminology, 1978 Many mice treated with a high single dose of PL died in convulsions. The convulsions were very similar to those induced with some anti B6 in several ways: (1) a long latent period occurs betfore convulsions; (2) PLP levels in brain decrease; (3) GABA levels in brain, especially in synaptosomal fraction, decrease.
Kimiharu Eto +4 more
openaire +4 more sources
PLoS ONE, 2021 Since 2012, studies in mice, rats, and humans have suggested that abnormalities in purinergic signaling may be a final common pathway for many genetic and environmental causes of autism spectrum disorder (ASD).
Zarazuela Zolkipli-Cunningham +10 more
doaj +1 more source
Learning the Hydrophilic, Hydrophobic and Aromatic Character of Amino Acids from their Interfacial Thermal Conductance in Water [PDF]
, 2021 In this study, the thermal relaxation of the 20 naturally occurring amino-acids in water is investigated using transient non-equilibrium molecular-dynamics simulations. By modeling the thermal relaxation process, the relaxation times of the amino-acids in water occurs over a timescale covering 2-5 ps.
arxiv +1 more source
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics [PDF]
, 2021 Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway.
Awwad, Hussain M. +9 more
core +1 more source
Reaction of Pyridoxal and Amino Acids in Methanol
Chemical and Pharmaceutical Bulletin, 1968 Reactions of amino acids and related amines with pyridoxal in methanol were studied by the changes of electronic absorption spectra. Most amino acids and amines formed Schiff bases, which existed in keto-enamine and enol-imine forms. Equilibrium between the two tautomeric forms was affected by the nature of amino acids or amine residues.
openaire +4 more sources
Applied Sciences, 2020 Chickpeas, a commonly consumed legume, are the main ingredient in traditional hummus. U.S. dietary guidelines recommend consuming 1–1.5 cups of legumes per week.
Cara L. Frankenfeld, Taylor C. Wallace
doaj +1 more source
The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model. [PDF]
PLoS ONE, 2013 BACKGROUND: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6.
Monique Albersen +8 more
doaj +1 more source
The effects of carboxylic acids on the aqueous dispersion and electrophoretic deposition of ZrO2 [PDF]
Journal of the European Ceramic Society, Volume 32, Issue 1, 2012,
Pages 235-244, 2013 The agglomeration, electrokinetic properties and electrophoretic deposition behaviour of aqueous suspensions of ZrO2 with carboxylic acid additives were studied in comparison with conventional pH adjustment. It was found that citric acid imparted negative zeta-potential values and electrosteric stabilisation to particles in suspensions at all pH levels.
arxiv +1 more source