Results 81 to 90 of about 5,110,049 (220)

Genotype, Ethnicity, and Drug–Drug Interaction Modeling as Means of Verifying Transporter Biomarker PBPK Model: The Coproporphyrin‐I Story

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 5, Page 941-953, May 2025.
ABSTRACT Coproporphyrin‐I (CP‐I) is a selective endogenous biomarker of organic anion‐transporting polypeptide (OATP)1B. Multiple CP‐I PBPK models with differing input parameters have been reported so far. This study proposed a harmonized CP‐I PBPK model and evaluated its ability to predict the effect of ethnicity, SLCO1B1 genotype c.521T>C, and sex on
Yuki Ujihira, Shawn Pei Feng Tan, Daniel Scotcher, Aleksandra Galetin   +3 more
wiley   +1 more source

Dietary supplementation with milk‐derived Bifidobacterium animalis subsp. lactis relieves colitis‐linked reproductive disorders via gut‐testis axis

iMetaOmics, Volume 2, Issue 1, March 2025.
The illustration of health benefits of Bifidobacterium animalis subsp. lactis NJ241 isolated from naturally fermented bovine milk. Integrative approaches unraveled that daily supplementation with Bifidobacterium animalis subsp. lactis NJ241 could markedly suppress colitis‐linked reproductive disorders through the gut‐testis axis.
Jingmin Lin, Lingzi Yin, Yueyao Fan, Zhiling Yu, Xin Ma, Xiuqiong Fu, Yong Zhang, Shaojun Tang, Jiali Chen   +8 more
wiley   +1 more source

Metabolomic Insights into Primary and Secondary Metabolites Variation in Common and Glutinous Rice (Oryza sativa L.)

Agronomy
: Interest in glutinous rice consumption has been expanding in East Asia. However, the extent of metabolite variation between common and glutinous rice has not been fully explored to identify metabolic targets for rice quality improvement.
Mingchao Zhao, Jingfen Huang, Junfang Ren, Xiaorong Xiao, Yapeng Li, Linan Zhai, Xiaowei Yan, Yong Yun, Qingwen Yang, Qingjie Tang, Funeng Xing, Weihua Qiao   +11 more
doaj   +1 more source

SYISL Knockout Promotes Embryonic Muscle Development of Offspring by Modulating Maternal Gut Microbiota and Fetal Myogenic Cell Dynamics

Advanced Science, Volume 12, Issue 6, February 10, 2025.
SYISL knockout significantly promotes embryonic muscle development and increases muscle fiber numbers of offspring by modulating maternal gut microbiota composition and butyrate‐HDAC‐H3K9ac/H3K27ac pathway. Furthermore, scRNA‐seq analysis shows that SYISL knockout alone significantly increases the number and proportion of myogenic cells and their ...
Hao Zuo, Wei Jiang, Jianwei Gao, Zhibo Ma, Chen Li, Yaxin Peng, Jianjun Jin, Xizhen Zhan, Wei Lv, Xiao Liu, Jingjing Hu, Mengdi Zhang, Yiming Jia, Zaiyan Xu, Junming Tang, Rong Zheng, Bo Zuo   +16 more
wiley   +1 more source

Effect of pyridoxal administration on the contents of pyridoxal phosphate and .GAMMA.-aminobutyric acid in mouse brain.

Journal of Nutritional Science and Vitaminology, 1978
Many mice treated with a high single dose of PL died in convulsions. The convulsions were very similar to those induced with some anti B6 in several ways: (1) a long latent period occurs betfore convulsions; (2) PLP levels in brain decrease; (3) GABA levels in brain, especially in synaptosomal fraction, decrease.
K, Eto, Y, Takahashi, M, Hoshino, T, Sakurai, M, Matsuda   +4 more
openaire   +3 more sources

Utility of Biomarker‐Informed Drug Interaction Evaluation in Drug Development and Regulatory Decision Making

Clinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 398-402, February 2025.
The measurement of endogenous biomarkers in plasma and urine before and after administration of an investigational drug in a clinical study may provide an early indication of its drug–drug interaction (DDI) potential via a specific pathway. In the first international harmonized guideline on drug interaction studies, the International Council for ...
Akihiro Ishiguro, Hiroyuki Kusuhara, Emi Kimoto, So Miyoshi, Katsuhiko Mizuno, Motohiro Hoshino, Hiroshi Suzuki   +6 more
wiley   +1 more source

Metabolomics study of graphene nuangong acupoint plaster for primary dysmenorrhea

Heliyon
Primary dysmenorrhea is a common gynecological disease with typical clinical symptoms and diverse treatment methods. Acupoint patch therapy is one of the traditional external treatments of traditional Chinese medicine, with a long history, and has been ...
Wu Liu, Ting Zhang, Zhaoduan Hu, Xin Li, Fuchun Wang, Rui Peng   +5 more
doaj   +1 more source

Metabolomics and Biochemical Benefits of Multivitamin and Multimineral Supplementation in Healthy Individuals: A Pilot Study

Foods
Scientific evidence regarding the effectiveness of vitamin and mineral supplements in healthy individuals remains scarce. In a randomized, double-blind study, 30 healthy individuals were assigned to receive a single daily dose of multivitamin and ...
María C. Sánchez, Ana Herráiz, María J. Ciudad, Marta Arias, Raquel Alonso, Carmen Doblas, Arancha Llama-Palacios, Luis Collado   +7 more
doaj   +1 more source

The close association of micronutrients with COVID-19

Heliyon
Objectives: The present study was conducted to explore the performance of micronutrients in the prediction and prevention of coronavirus disease 2019 (COVID-19). Methods: This is an observational case-control study.
Aimin Zhang, Yue Yin, Jiashu Tian, Xialin Wang, Zhihong Yue, Lin Pei, Li Liu, Li Qin, Mei Jia, Hui Wang, Qingwei Ma, Wei-bo Gao, Lin-Lin Cao   +12 more
doaj   +1 more source

Issue Information

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 5, Page 813-816, May 2025.
wiley   +1 more source