Results 161 to 170 of about 2,422 (193)
Some of the next articles are maybe not open access.
Chronic Toxicity/Carcinogenicity Study of Pyrilamine in B6C3F1 Mice
Journal of the American College of Toxicology, 1995The chronic toxicity and carcinogenicity of pyrilamine maleate were evaluated in B6C3F1 mice by feeding for up to 2 years to groups of 60 male or female mice at dietary levels of 0,150, 750, or 1,500 ppm (as the free base). Up to 12 mice per sex and dose group were killed after 65 weeks for clinical chemistry, hematology, and histopathologic ...
David L. Greenman +4 more
openaire +1 more source
Chromatographic Analysis of Chlorpheniramine, Pyrilamine, and Methapyrilene in Combination
Journal of Pharmaceutical Sciences, 1969A partition chromatographic method is presented for the separation and quantitation of chlorpheniramine, methapyrilene, and pyrilamine in combination.A solution of p-toluenesulfonic acid and potassium chloride on a column of diatomaceous earth is used to effect the separation.The isolated chlorpheniramine is determined by UV spectrophotometry.The ...
openaire +2 more sources
Effect of Cimetidine and Pyrilamine on Histamine-Induced Ocular Surface Hyperemia
Journal of Ocular Pharmacology and Therapeutics, 1986Histamine-induced ocular surface redness was virtually abolished by a combination of cimetidine (H2-receptor antagonist) and pyrilamine (H1-receptor antagonist), whereas either antagonist administered alone produced no significant reduction. It appears that combined H1- and H2-antagonist therapy is required for effective blockade of ocular responses to
D F, Woodward +3 more
openaire +2 more sources
Identification of urinary metabolites of pyrilamine after oral administration to man
Xenobiotica, 19941. The metabolism of pyrilamine, 2-[4-methoxybenzyl-(2-dimethylaminoethyl) amino] pyridine, was studied in adult male volunteers after a single oral dose of 50 mg. 2. Solvent extracts of urine obtained with or without enzyme hydrolysis were analysed by gc/ms after derivatization with MSTFA/TMSCI (N-methyl-N-trimethylsilyl-trifluoroacetamide/trimethyl ...
B C, Chung +5 more
openaire +2 more sources
Ascorbate increases apparent “specific” binding of [3H]pyrilamine to glass fiber filters
Journal of Pharmacological Methods, 1988Although filtration through glass fiber filters provides a convenient method for separating bound from unbound radioligand, binding of the ligand to the filters is often a problem. Ascorbate (0.1%) has been shown to decrease binding of serotonergic acids to these filters. In the present study, relatively high binding of [3H]pyrilamine, an H1-antagonist,
P B, Williams, M D, Rosenthal
openaire +2 more sources
The Effects of Pyrilamine on the Selectivity of Phonotaxis
2023Hormones modulate phonotactic behaviors of female crickets (Acheta domesticus). This project seeks to observe the changes in phonotactic behavior when anti-histamine is injected in the prothoracic ganglion. The anti-histamine used, pyrilamine, resulted in older, unselective females becoming more selective to the male calling songs.
openaire +1 more source
Effects of chlorpheniramine, pyrilamine and astemizole on intracranial self-stimulation in rats
European Journal of Pharmacology, 1981Rats implanted in the lateral hypothalamus were used to assess lever pressing for brain stimulation. Lever pressing was increased dose-dependently by chlorpheniramine and decreased dose-dependently by pyrilamine. Astemizole, a new orally long-acting antihistamine did not affect self-stimulation.
A, Wauquier, C J, Niemegeers
openaire +2 more sources
The General Toxicology Unknown II. A Case Report: Doxylamine and Pyrilamine Intoxication
Journal of Forensic Sciences, 1983Abstract A general toxicology unknown case is presented to demonstrate our systematic approach. A 20-year-old male was found dead with multiple suicide notes. Overdose was suspected but substances were not known. Blood alcohol was negative.
N B, Wu Chen +5 more
openaire +2 more sources
The metabolism and elimination of pyrilamine maleate in the rat.
Drug Metabolism and Disposition, 1987The metabolism and elimination of pyrilamine (2-[(2-dimethylamino-ethyl)(p-methoxybenzyl)amino]pyridine) were characterized after the iv administration of 7.0 mg/kg or 0.7 mg/kg pyrilamine maleate plus [14C]pyrilamine maleate to adult male Fischer-344 rats.
D W, Kelly, W, Slikker
openaire +2 more sources
Histamine H1 antagonist treatment with pyrilamine reduces nicotine self-administration in rats
European Journal of Pharmacology, 2011Nicotine has been definitively shown to be critically involved in the neural bases of tobacco addiction. However, nicotine releases a wide variety of neurotransmitters. Nicotine-induced dopamine release has been shown to play a key role in facilitating nicotine self-administration.
Edward D, Levin +8 more
openaire +2 more sources