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Pyrilamine/Caffeine/Acetaminophen
Definitions, 2020 Pyrilamine is an ethylenediamine antihistamine that blocks H1 receptors and exerts local anesthetic, sedative and mild analgesic activities. Caffeine is a central nervous system stimulant. Acetaminophen possesses analgesic and antipyretic effects.
National Cancer Institute
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Novel potentiometric sensors for pyrilamine maleate
Journal of the Iranian Chemical Society, 2017The fabrication and electrochemical response characteristics of four novel potentiometric sensors for determination of pyrilamine maleate (PyraH) were described. The sensors include polymeric membrane electrodes (PME1, PME2) and carbon paste electrodes (CPE1, CPE2).
M. Khalil, Y. M. Issa, S. M. Mostafa
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Pyrilamine inhibits nicotine-induced catecholamine secretion
Neurochemistry International, 2014Function of nicotine, which induces activation of all parts of the body including our brain, has been receiving much attention for a long period of time and also been actively studied by researchers for its pharmacological actions in the central nervous system.
Dong-Chan Kim +7 more
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Drug Metabolism And Disposition, 2023 Our recent study has revealed that SLC49A4, known as disrupted in renal carcinoma 2, is an H+-coupled lysosomal exporter for pyridoxine (vitamin B6), a cationic compound.
Shogo Akino +4 more
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Subchronic Studies of Pyrilamine in Fischer 344 Rats [PDF]
Journal of the American College of Toxicology, 1993 This study was designed to determine the subchronic effects of the antihistamine, pyrilamine maleate, and to establish dose levels for a 2-year chronic study. Six male and six female F344 rats received dietary pyrilamine concentrations of 0, 392, 783, 1563, 3122, or 6276 ppm (as the free base) for 14 days.
David L. Greenman +3 more
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Chronic Toxicity/Carcinogenicity Study of Pyrilamine in B6C3F1 Mice [PDF]
Journal of the American College of Toxicology, 1995 The chronic toxicity and carcinogenicity of pyrilamine maleate were evaluated in B6C3F1 mice by feeding for up to 2 years to groups of 60 male or female mice at dietary levels of 0,150, 750, or 1,500 ppm (as the free base). Up to 12 mice per sex and dose group were killed after 65 weeks for clinical chemistry, hematology, and histopathologic ...
David L. Greenman +4 more
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A Fatal Case Involving Pyrilamine
Clinical Toxicology, 1981 AbstractA death attributed to ingestion of pyrilamine in over-the-counter sleep aids is reported. Tissue concentrations and methods for detection and quantitation are presented.
Greg Johnson
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Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.
European Journal of Pharmacology, 2011Nicotine has been definitively shown to be critically involved in the neural bases of tobacco addiction. However, nicotine releases a wide variety of neurotransmitters. Nicotine-induced dopamine release has been shown to play a key role in facilitating nicotine self-administration.
E. Levin +8 more
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