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Pyrilamine-induced prolonged QT interval in adolescent with drug overdose.
Pediatric Emergency Care, 2011The widespread availability of antihistamines in many over-the-counter preparations can lead to significant hazard to the public because of their possible link to potential ventricular arrhythmias secondary to prolongation of QT interval. The effect can be further compounded by the use of other commonly used medications such as macrolides, antifungal ...
Govinda Paudel +3 more
semanticscholar +3 more sources
Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats.
Food and Chemical Toxicology, 1984Methapyrilene hydrochloride was administered at levels of 125 or 250 ppm in the diet to groups of male and female F344 rats. The closely analogous antihistaminic drug pyrilamine, as the maleate, was given at 2000 ppm in the diet or at 2 g/litre drinking-water to groups of male and female F344 rats.
W. Lijinsky
semanticscholar +3 more sources
Biomedical & environmental mass spectrometry, 1990 Combined high-performance liquid chromatography/thermospray mass spectrometry (HPLC/TSMS) and HPLC/thermospray tandem mass spectrometry (HPLC/TSMS/MS) were utilized for the analysis of rat urine for metabolites of pyrilamine.
Walter A. Korfmacher +4 more
semanticscholar +2 more sources
Chromatographic Analysis of Chlorpheniramine, Pyrilamine, and Methapyrilene in Combination
Journal of Pharmaceutical Sciences, 1969 A partition chromatographic method is presented for the separation and quantitation of chlorpheniramine, methapyrilene, and pyrilamine in combination.A solution of p-toluenesulfonic acid and potassium chloride on a column of diatomaceous earth is used to effect the separation.The isolated chlorpheniramine is determined by UV spectrophotometry.The ...
Bobby R. Rader
openaire +3 more sources
Effects of chlorpheniramine, pyrilamine and astemizole on intracranial self-stimulation in rats.
European Journal of Pharmacology, 1981Rats implanted in the lateral hypothalamus were used to assess lever pressing for brain stimulation. Lever pressing was increased dose-dependently by chlorpheniramine and decreased dose-dependently by pyrilamine. Astemizole, a new orally long-acting antihistamine did not affect self-stimulation.
Albert Wauquier, C. Niemegeers
semanticscholar +3 more sources
The metabolism and elimination of pyrilamine maleate in the rat.
Drug Metabolism and Disposition, 1987 The metabolism and elimination of pyrilamine (2-[(2-dimethylamino-ethyl)(p-methoxybenzyl)amino]pyridine) were characterized after the iv administration of 7.0 mg/kg or 0.7 mg/kg pyrilamine maleate plus [14C]pyrilamine maleate to adult male Fischer-344 rats.
D W, Kelly, W, Slikker
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Ascorbate increases apparent “specific” binding of [3H]pyrilamine to glass fiber filters
Journal of Pharmacological Methods, 1988 Although filtration through glass fiber filters provides a convenient method for separating bound from unbound radioligand, binding of the ligand to the filters is often a problem. Ascorbate (0.1%) has been shown to decrease binding of serotonergic acids to these filters. In the present study, relatively high binding of [3H]pyrilamine, an H1-antagonist,
P B, Williams, M D, Rosenthal
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