Pyrilamine - Open Access .click

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[Research progress of pyrilamine-sensitive H~+/OC antiporter].

Yao xue xue bao = Acta pharmaceutica Sinica, 2018
In recent years, a new type of organic cation transporter has been found to transport organic cation drugs like pyrilamine, diphenhydramine and oxycodone in brain capillary endothelial cells, Caco-2 cells and other cells. Its transport activity can not be inhibited by typical organic cation transporter substrates or inhibitors, and its transport ...
Xin-yi, Wang, Zhi-rong, Zhang
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Antihistamine drugs on rat pregnancy: Effects of pyrilamine and meclizine

Life Sciences, 1963
Abstract Pyrilamine administration in the early stages of pregnancy in the rat caused: a) an increase in the frequency of implantation anomalies and b) several toxic effects appearing in the last stages of pregnancy. Meclizine, on the other hand, had virtually no effects.
F. Bovet-Nitti, G. Bignami, D. Bovet
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Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats

Food and Chemical Toxicology, 1984
Methapyrilene hydrochloride was administered at levels of 125 or 250 ppm in the diet to groups of male and female F344 rats. The closely analogous antihistaminic drug pyrilamine, as the maleate, was given at 2000 ppm in the diet or at 2 g/litre drinking-water to groups of male and female F344 rats.
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Efficacy of Cimetidine/Pyrilamine Eyedrops