Results 1 to 10 of about 34,811 (248)

Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda. [PDF]

open access: yesPLoS Medicine
BackgroundTo mitigate adverse consequences of malaria in pregnancy, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine.
Abel Kakuru   +18 more
doaj   +2 more sources

Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo [PDF]

open access: goldJournal of Toxicology, 2022
Background. The sulfadoxine-pyrimethamine combination is a product used in the intermittent preventive treatment (IPT) of malaria in pregnant women in our country. To date, there is very little data on the teratogenic effect of this product.
Rachida Moussa Tari   +8 more
doaj   +2 more sources

Study of anti-Toxoplasma gondii effect of mPEG–PCL copolymeric loaded with pyrimethamine, in vitro [PDF]

open access: yesAMB Express
The discovery of new drugs with minimal toxicity is crucially important in the search for effective treatments for toxoplasmosis. The study aimed to assess the effectiveness of pyrimethamine-loaded mPEG–PCL copolymeric nanoparticles (mPEG–PCL–Pyr ...
Mobina Gholami   +5 more
doaj   +2 more sources

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysisResearch in context [PDF]

open access: yesEClinicalMedicine
Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an ...
Michelle E. Roh   +25 more
doaj   +2 more sources

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

open access: yesPharmaceuticals, 2021
Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis.
Giusy Tassone   +8 more
doaj   +1 more source

Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening

open access: yesMolecules, 2021
In this work, co-crystal screening was carried out for two important dihydrofolate reductase (DHFR) inhibitors, trimethoprim (TMP) and pyrimethamine (PMA), and for 2,4-diaminopyrimidine (DAP), which is the pharmacophore of these active pharmaceutical ...
João A. Baptista   +7 more
doaj   +1 more source

Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model

open access: yesPathogens, 2023
We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we evaluated the effect of transdermal therapy (tdt) of N-89 in combination (tdct) with other antimalarials as an application ...
Nagwa S. M. Aly   +8 more
doaj   +1 more source

Paediatric malaria case-management with Artemether-Lumefantrine in Zambia: a repeat cross-sectional study [PDF]

open access: yes, 2007
BACKGROUND Zambia was the first African country to change national antimalarial treatment policy to artemisinin-based combination therapy – artemether-lumefantrine.
Dejan Zurovac   +36 more
core   +13 more sources

Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2

open access: yesMolecules, 2020
While aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a tumor suppressor, its exon 2-depleted splice variant (AIMP2-DX2 or shortly DX2) is highly expressed in human lung cancer, and the ratio of DX2 to AIMP2 increases according
Dae Gyu Kim   +5 more
doaj   +1 more source

Genomic characterization of Plasmodium falciparum genes associated with anti-folate drug resistance and treatment outcomes in eastern India: A molecular surveillance study from 2008 to 2017

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
IntroductionAfter being used vigorously for the previous two decades to treat P. falciparum, chloroquine and sulfadoxine-pyrimethamine were replaced in 2009 with an artemisinin-based combination therapy (artesunate-sulfadoxine-pyrimethamine) in an effort
Sabyasachi Das   +7 more
doaj   +1 more source

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