Results 1 to 10 of about 42,095 (230)

Intermittent preventive treatment of malaria in pregnancy: a cross-sectional survey to assess uptake of the new sulfadoxine–pyrimethamine five dose policy in Ghana [PDF]

Malaria Journal, 2017
Malaria in pregnancy poses a great risk to both mother and fetus. In Ghana, malaria accounts for 3.4% of deaths and 16.8% of all hospital admissions in pregnant women.
I. Owusu-Boateng, F. Anto
semanticscholar   +2 more sources

Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in the Democratic Republic of the Congo: emergence of highly resistant pfdhfr/pfdhps alleles [PDF]

Journal of Antimicrobial Chemotherapy, 2018
Background In 2005, the Democratic Republic of the Congo (DRC) switched to artesunate/amodiaquine as the first-line antimalarial in response to increasing sulfadoxine/pyrimethamine resistance and adopted intermittent preventive treatment using ...
P. Nkoli Mandoko, Florent Rouvier, Lebon Matendo Kakina, D. Moke Mbongi, Christine Latour, J. Losimba Likwela, D. Ngoyi Mumba, S. K. Bi Shamamba, Jean-Jacques Tamfum Muyembe, L. Muepu Tshilolo, D. Parzy, V. Sinou   +11 more
semanticscholar   +2 more sources

Synergistic activity of RSL3 and Pyrimethamine to inhibit the proliferation of <i>Plasmodium falciparum</i>. [PDF]

Antimicrob Agents Chemother
Nikolova V, Linnemannstöns K, Zahoruiko A, Ganter M, Lüder CG, Dobbelstein M.   +5 more
europepmc   +2 more sources

Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review

Frontiers in Genetics, 2021
Malaria is a great concern for global health and accounts for a large amount of morbidity and mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the disease.
A. Roux, Leah Maharaj, O. Oyegoke, Oluwasegun P. Akoniyon, M. Adeleke, R. Maharaj, Moses Okpeku   +6 more
semanticscholar   +1 more source

Differentials in prevalence and correlates on uptake of tetanus toxoid and intermittent preventive treatment with sulfadoxine-pyrimethamine during pregnancy: A community-based cross-sectional study in The Gambia

SAGE Open Medicine, 2022
Objectives: The study examined the differentials in prevalence and correlates on the uptake of tetanus toxoid and intermittent preventive treatment of malaria among pregnant women in The Gambia.
A. Barrow, Sulayman Barrow, Amienatta Jobe   +2 more
semanticscholar   +1 more source

Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8+ T-cell mediated cytotoxicity in colorectal cancer

Molecular Biology Reports, 2022
The emergence of nonresponse or resistance to traditional chemotherapeutic agents is one of the main challenges of colorectal cancer (CRC) therapies. Thus, novel therapeutic drugs that can improve the clinical outcomes of CRC patients are urgently needed.
Haiyan Dong, Limei Hu, Weiqian Li, Meng-Ya Shi, Ling-yan He, Chen Wang, Yijia Hu, Huihui Wang, Chuangyu Wen, Huanliang Liu, Xiangling Yang   +10 more
semanticscholar   +1 more source

Paediatric malaria case-management with Artemether-Lumefantrine in Zambia: a repeat cross-sectional study [PDF]

, 2007
BACKGROUND Zambia was the first African country to change national antimalarial treatment policy to artemisinin-based combination therapy – artemether-lumefantrine.
Dejan Zurovac, Mickey Ndhlovu, Nawa Sipilanyambe, Pascalina Chanda, Davidson H Hamer, Jon L Simon, Robert W Snow, P Olumese, RW Snow, International Artemisinin Study Group, AK Rowe, AK Rowe, D Zurovac, DM Osterholt, F Font, N Nshakira, D Zurovac, AK Rowe, J Armstrong-Schellenberg, HM Bijl, National Malaria Control Centre, DH Hamer, D Zurovac, Central Board of Health, Central Board of Health, National Malaria Control Centre, National Malaria Control Centre, Central Board of Health, Central Board of Health, EM Malik, P Chanda, C Falade, Republic of Kenya, United Republic of Tanzania, Republic of Uganda, R Shretta, HA Williams   +36 more
core   +13 more sources

Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in Africa: a systematic analysis of national trends

BMJ Global Health, 2020
Introduction The rising burden of drug resistance is a major challenge to the global fight against malaria. We estimated national Plasmodium falciparum resistance to sulfadoxine-pyrimethamine (SP) across Africa, from 2000 to 2020.
F. Amimo, B. Lambert, A. Magit, J. Sacarlal, M. Hashizume, K. Shibuya   +5 more
semanticscholar   +1 more source

Understanding the Pyrimethamine Drug Resistance Mechanism via Combined Molecular Dynamics and Dynamic Residue Network Analysis

Molecules, 2020
In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the ...
Arnold Amusengeri, R. Tata, Özlem Tastan Bishop   +2 more
semanticscholar   +1 more source

Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2

Molecules, 2020
While aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a tumor suppressor, its exon 2-depleted splice variant (AIMP2-DX2 or shortly DX2) is highly expressed in human lung cancer, and the ratio of DX2 to AIMP2 increases according
Dae Kim, C. Park, Srigouri Huddar, Semi Lim, Sunghoon Kim, Sunkyung Lee   +5 more
semanticscholar   +1 more source