Results 1 to 10 of about 42,597 (297)

Understanding the Pyrimethamine Drug Resistance Mechanism via Combined Molecular Dynamics and Dynamic Residue Network Analysis

Molecules, 2020
In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the ...
Arnold Amusengeri, Rolland Bantar Tata, Özlem Tastan Bishop   +2 more
doaj   +2 more sources

Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2

Molecules, 2020
While aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a tumor suppressor, its exon 2-depleted splice variant (AIMP2-DX2 or shortly DX2) is highly expressed in human lung cancer, and the ratio of DX2 to AIMP2 increases according
Dae Gyu Kim, Chul Min Park, Srigouri Huddar, Semi Lim, Sunghoon Kim, Sunkyung Lee   +5 more
doaj   +2 more sources

Pyrimethamine Elicits Antitumor Effects on Prostate Cancer by Inhibiting the p38-NF-κB Pathway

Frontiers in Pharmacology, 2020
Since incurable castration-resistant prostate cancer (CRPC) inevitably develops following treatment with androgen deprivation therapy, there is an urgent need to devise new therapeutic strategies to treat this cancer.
Xumin Zhou, Xumin Zhou, Jinming Zhang, Xiaoping Hu, Peiqing He, Jianyu Guo, Jun Li, Tian Lan, Jumei Liu, Lilan Peng, Hua Li   +10 more
doaj   +2 more sources

Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda. [PDF]

PLoS Medicine
BackgroundTo mitigate adverse consequences of malaria in pregnancy, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine.
Abel Kakuru, Jimmy Kizza, Miriam Aguti, Harriet Adrama, John Ategeka, Peter Olwoch, Miriam Nakalembe, Joaniter I Nankabirwa, Bishop Opira, Nida Ozarslan, Anju Ranjit, Erin Dela Cruz, Tamara D Clark, Michelle E Roh, Stephanie L Gaw, Prasanna Jagannathan, Philip J Rosenthal, Moses R Kamya, Grant Dorsey   +18 more
doaj   +2 more sources

Pyrimethamine Triggers the Apoptotic Pathway in Mucoepidermoid Carcinoma in Cell‐Based Models [PDF]

Journal of Oral Pathology &Medicine, Volume 54, Issue 8, Page 723-732, September 2025.
ABSTRACT Background Mucoepidermoid carcinoma (MEC) is the most prevalent salivary gland malignancy, with a poor prognosis in high‐grade tumors at diagnosis. This highlights the need for effective antitumor agents for treating MEC. Therefore, we aimed to investigate the antineoplastic efficacy of pyrimethamine (PYR), a Food and Drug Administration ...
Hyun‐Ji Kim, Dong‐Guk Park, Su‐Jung Choi, Jae‐Jin Cho, Seong‐Doo Hong, Sung‐Dae Cho   +5 more
wiley   +2 more sources

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysisResearch in context [PDF]

EClinicalMedicine
Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an ...
Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile   +25 more
doaj   +2 more sources

Pyrimethamine poisoning. [PDF]

BMJ, 1973
O Akinyanju, J C Goddell, IBRAHIM NASRELDIN IBRAHIM AHMED   +2 more
openalex   +4 more sources

Study of anti-Toxoplasma gondii effect of mPEG–PCL copolymeric loaded with pyrimethamine, in vitro [PDF]

AMB Express
The discovery of new drugs with minimal toxicity is crucially important in the search for effective treatments for toxoplasmosis. The study aimed to assess the effectiveness of pyrimethamine-loaded mPEG–PCL copolymeric nanoparticles (mPEG–PCL–Pyr ...
Mobina Gholami, Hossein Danafer, Mitra Sadeghi, Ahmad Daryani, Seyed Abdollah Hosseini, Shirzad Gholami   +5 more
doaj   +2 more sources

Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia. [PDF]

PLoS ONE, 2015
Antimalarial drug resistance is one of the major challenges in global efforts of malaria control and elimination. In 1998, chloroquine was abandoned and replaced with sulfadoxine/pyrimethamine, which in turn was replaced with artemether/lumefantrine for ...
Sofonias K Tessema, Moges Kassa, Amha Kebede, Hussein Mohammed, Gemechu Tadesse Leta, Adugna Woyessa, Geremew Tasew Guma, Beyene Petros   +7 more
doaj   +2 more sources

Molecular evidence of increased resistance to anti-folate drugs in Plasmodium falciparum in North-East India: a signal for potential failure of artemisinin plus sulphadoxine-pyrimethamine combination therapy. [PDF]

PLoS ONE, 2014
North-east India, being a corridor to South-east Asia, is believed to play an important role in transmitting drug resistant Plasmodium falciparum malaria to India and South Asia.
Pradyumna Kishore Mohapatra, Devojit Kumar Sarma, Anil Prakash, Khukumoni Bora, Md Atique Ahmed, Bibhas Sarma, Basanta Kumar Goswami, Dibya Ranjan Bhattacharyya, Jagadish Mahanta   +8 more
doaj   +2 more sources