Results 11 to 20 of about 42,597 (297)
Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review
Frontiers in Genetics, 2021 Malaria is a great concern for global health and accounts for a large amount of morbidity and mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the disease.
A. Roux +6 more
semanticscholar +1 more source
Pharmaceuticals, 2021 Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis.
Giusy Tassone +8 more
doaj +1 more source
Molecular Biology Reports, 2022 The emergence of nonresponse or resistance to traditional chemotherapeutic agents is one of the main challenges of colorectal cancer (CRC) therapies. Thus, novel therapeutic drugs that can improve the clinical outcomes of CRC patients are urgently needed.
Haiyan Dong +10 more
semanticscholar +1 more source
Paediatric malaria case-management with Artemether-Lumefantrine in Zambia: a repeat cross-sectional study [PDF]
, 2007 BACKGROUND Zambia was the first African country to change national antimalarial treatment policy to artemisinin-based combination therapy – artemether-lumefantrine.
Dejan Zurovac +36 more
core +16 more sources
Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model
Pathogens, 2023 We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we evaluated the effect of transdermal therapy (tdt) of N-89 in combination (tdct) with other antimalarials as an application ...
Nagwa S. M. Aly +8 more
doaj +1 more source
Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening
Molecules, 2021 In this work, co-crystal screening was carried out for two important dihydrofolate reductase (DHFR) inhibitors, trimethoprim (TMP) and pyrimethamine (PMA), and for 2,4-diaminopyrimidine (DAP), which is the pharmacophore of these active pharmaceutical ...
João A. Baptista +7 more
doaj +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView., 2023 Abstract Objective To examine prevalence of novel newborn types among 541 285 live births in 23 countries from 2000 to 2021. Design Descriptive multi‐country secondary data analysis. Setting Subnational, population‐based birth cohort studies (n = 45) in 23 low‐ and middle‐income countries (LMICs) spanning 2000–2021.
D. J. Erchick +189 more
wiley +1 more source
BMJ Global Health, 2020 Introduction The rising burden of drug resistance is a major challenge to the global fight against malaria. We estimated national Plasmodium falciparum resistance to sulfadoxine-pyrimethamine (SP) across Africa, from 2000 to 2020.
F. Amimo +5 more
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 IntroductionAfter being used vigorously for the previous two decades to treat P. falciparum, chloroquine and sulfadoxine-pyrimethamine were replaced in 2009 with an artemisinin-based combination therapy (artesunate-sulfadoxine-pyrimethamine) in an effort
Sabyasachi Das +7 more
doaj +1 more source
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Disease Models & Mechanisms, 2021 Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) is a potent inducer of vascular permeability.
Li Wang +7 more
doaj +1 more source