Results 11 to 20 of about 43,381 (288)

Pyrimethamine Elicits Antitumor Effects on Prostate Cancer by Inhibiting the p38-NF-κB Pathway

Frontiers in Pharmacology, 2020
Since incurable castration-resistant prostate cancer (CRPC) inevitably develops following treatment with androgen deprivation therapy, there is an urgent need to devise new therapeutic strategies to treat this cancer.
Xu-min Zhou, Jinming Zhang, Xiaoping Hu, Peiqing He, Jianyu Guo, Jun Li, T. Lan, Jumei Liu, Lilan Peng, Hua Li   +9 more
semanticscholar   +3 more sources

Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia [PDF]

PLoS ONE, 2015
Antimalarial drug resistance is one of the major challenges in global efforts of malaria control and elimination. In 1998, chloroquine was abandoned and replaced with sulfadoxine/pyrimethamine, which in turn was replaced with artemether/lumefantrine for ...
S. Tessema, M. Kassa, A. Kebede, H. Mohammed, G. Leta, Adugna Woyessa, G. Guma, B. Petros   +7 more
semanticscholar   +2 more sources

Molecular Evidence of Increased Resistance to Anti-Folate Drugs in Plasmodium falciparum in North-East India: A Signal for Potential Failure of Artemisinin Plus Sulphadoxine-Pyrimethamine Combination Therapy [PDF]

PLoS ONE, 2014
North-east India, being a corridor to South-east Asia, is believed to play an important role in transmitting drug resistant Plasmodium falciparum malaria to India and South Asia.
P. Mohapatra, D. Sarma, A. Prakash, K. Bora, Md Atique Ahmed, Bibhas Sarma, B. K. Goswami, D. Bhattacharyya, J. Mahanta   +8 more
semanticscholar   +2 more sources

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

Pharmaceuticals, 2021
Trypanosoma and Leishmania parasites are the etiological agents of various threatening neglected tropical diseases (NTDs), including human African trypanosomiasis (HAT), Chagas disease, and various types of leishmaniasis.
Giusy Tassone, Giacomo Landi, Pasquale Linciano, Valeria Francesconi, Michele Tonelli, Lorenzo Tagliazucchi, Maria Paola Costi, Stefano Mangani, Cecilia Pozzi   +8 more
doaj   +1 more source

Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening

Molecules, 2021
In this work, co-crystal screening was carried out for two important dihydrofolate reductase (DHFR) inhibitors, trimethoprim (TMP) and pyrimethamine (PMA), and for 2,4-diaminopyrimidine (DAP), which is the pharmacophore of these active pharmaceutical ...
João A. Baptista, Mário T. S. Rosado, Ricardo A. E. Castro, António O. L. Évora, Teresa M. R. Maria, Manuela Ramos Silva, João Canotilho, M. Ermelinda S. Eusébio   +7 more
doaj   +1 more source

Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda. [PDF]

PLoS Med
BackgroundTo mitigate adverse consequences of malaria in pregnancy, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine.
Kakuru A, Kizza J, Aguti M, Adrama H, Ategeka J, Olwoch P, Nakalembe M, Nankabirwa JI, Opira B, Ozarslan N, Ranjit A, Dela Cruz E, Clark TD, Roh ME, Gaw SL, Jagannathan P, Rosenthal PJ, Kamya MR, Dorsey G.   +18 more
europepmc   +2 more sources

Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model

Pathogens, 2023
We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we evaluated the effect of transdermal therapy (tdt) of N-89 in combination (tdct) with other antimalarials as an application ...
Nagwa S. M. Aly, Hiroaki Matsumori, Thi Quyen Dinh, Akira Sato, Shin-Ichi Miyoshi, Kyung-Soo Chang, Hak Sun Yu, Duc Tuan Cao, Hye-Sook Kim   +8 more
doaj   +1 more source

Strongyloides Antigens Alter Cytokines Responses in Toxoplasma gondii-Infected BeWo Trophoblast Cells. [PDF]

Cell Biol Int
ABSTRACT The importance of co‐infections is not yet completely understood, and the impact and direction of their effects vary considerably. This study aimed to evaluate the role of total saline extract (TS) and excretory/secretory (ES) products of Strongyloides venezuelensis filarioid larvae on a maternal‐interface cell model during Toxoplasma gondii ...
Alves FT, Jesus BCG, Diniz MES, Luz LC, Franco PS, Ribeiro VDS, de Carvalho EFG, Barbosa BF, Gonzaga HT.   +8 more
europepmc   +2 more sources

Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability

Disease Models & Mechanisms, 2021
Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) is a potent inducer of vascular permeability.
Li Wang, Matteo Astone, Sk. Kayum Alam, Zhu Zhu, Wuhong Pei, David A. Frank, Shawn M. Burgess, Luke H. Hoeppner   +7 more
doaj   +1 more source

Efficacy and effectiveness of the combination of sulfadoxine/pyrimethamine and a 3-day course of artesunate for the treatment of uncomplicated falciparum malaria in a refugee settlement in Zambia. [PDF]

, 2005
In the Maheba Refugee Settlement, in the clinics supported by Medecins Sans Frontieres, all children aged up to 5 years with a confirmed diagnosis of uncomplicated falciparum malaria are treated with the combination of sulfadoxine/pyrimethamine (SP) and ...
Bloland PB, Contamin H, National Malaria Control Centre, Nosten F, Peterson DS, Trape JF, Vasconcelos KF, White NJ, World Health Organisation (WHO), World Health Organisation (WHO)   +9 more
core   +2 more sources