Molecules, 2020 In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the ...
Arnold Amusengeri +2 more
doaj +2 more sources
Pyrimethamine Elicits Antitumor Effects on Prostate Cancer by Inhibiting the p38-NF-κB Pathway
Frontiers in Pharmacology, 2020 Since incurable castration-resistant prostate cancer (CRPC) inevitably develops following treatment with androgen deprivation therapy, there is an urgent need to devise new therapeutic strategies to treat this cancer.
Xumin Zhou +10 more
doaj +2 more sources
Efficacy of sulphadoxine-pyrimethamine + artesunate, sulphadoxine-pyrimethamine + amodiaquine, and sulphadoxine-pyrimethamine alone in uncomplicated falciparum malaria in Mali [PDF]
Malaria Journal, 2015 Plasmodium falciparum resistance to artemisinin has been reported in South-East Asia. Long half-life drugs are increasingly being used for malaria prevention. The potential spread of parasite resistance to these regimens is real and makes regular efficacy surveillance a priority.From August to December 2004 and July to December 2005, a randomized open ...
Abdoul H. Beavogui +15 more
openaire +4 more sources
Pyrimethamine poisoning. [PDF]
BMJ, 1973 O, Akinyanju, J C, Goddell, I, Ahmed
openaire +4 more sources
Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia. [PDF]
PLoS ONE, 2015 Antimalarial drug resistance is one of the major challenges in global efforts of malaria control and elimination. In 1998, chloroquine was abandoned and replaced with sulfadoxine/pyrimethamine, which in turn was replaced with artemether/lumefantrine for ...
Sofonias K Tessema +7 more
doaj +2 more sources
Molecular evidence of increased resistance to anti-folate drugs in Plasmodium falciparum in North-East India: a signal for potential failure of artemisinin plus sulphadoxine-pyrimethamine combination therapy. [PDF]
PLoS ONE, 2014 North-east India, being a corridor to South-east Asia, is believed to play an important role in transmitting drug resistant Plasmodium falciparum malaria to India and South Asia.
Pradyumna Kishore Mohapatra +8 more
doaj +2 more sources
Molecular Biology Reports, 2022 The emergence of nonresponse or resistance to traditional chemotherapeutic agents is one of the main challenges of colorectal cancer (CRC) therapies. Thus, novel therapeutic drugs that can improve the clinical outcomes of CRC patients are urgently needed.
Haiyan Dong +10 more
semanticscholar +1 more source
Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review
Frontiers in Genetics, 2021 Malaria is a great concern for global health and accounts for a large amount of morbidity and mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the disease.
A. Roux +6 more
semanticscholar +1 more source
BMJ Global Health, 2020 Introduction The rising burden of drug resistance is a major challenge to the global fight against malaria. We estimated national Plasmodium falciparum resistance to sulfadoxine-pyrimethamine (SP) across Africa, from 2000 to 2020.
F. Amimo +5 more
semanticscholar +1 more source
Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions? [PDF]
, 2012 A recent meta-analysis of mosquito feeding assays to determine the Plasmodium falciparum transmission potential of naturally infected gametocyte carriers highlighted considerable variation in transmission efficiency between assay methodologies and ...
Bousema, Teun +3 more
core +8 more sources