Results 31 to 40 of about 34,530 (252)

Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone. [PDF]

, 2006
OBJECTIVE: In 2004, Sierra Leone adopted artesunate plus amodiaquine as first-line antimalarial treatment. We evaluated the efficacy of this combination in Kailahun, where a previous study had shown 70.2% efficacy of amodiaquine in monotherapy.
Balkan, S, Checchi, F, Durand, R, Grandesso, F, Guthmann, J P, Hagerman, A, Kamara, S, Lam, E, Scollo, G   +8 more
core   +2 more sources

Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres

Pathogens
During pregnancy, primary Toxoplasma gondii infection can cause congenital toxoplasmosis (CT). We described the newborns’ outcomes from a multicentre cohort of mothers with seroconversion (SC) at different gestational ages.
Alice Bonetti, Agnese Comelli, Annacarla Chiesa, Vania Spinoni, Ambra Vola, Federico Prefumo, Adriana Valcamonico, Carlo Bonfanti, Silvio Caligaris, Lina Rachele Tomasoni, Fausto Baldanti, Valeria Meroni   +11 more
doaj   +1 more source

Options for clinical trials of pre and post-natal treatments for congenital toxoplasmosis

Memorias do Instituto Oswaldo Cruz, 2009
Clinical trials comparing different drug regimens and strategies for the treatment of congenital toxoplasmosis and its clinical manifestations in the liveborn child in different clinical settings should aim at formally evaluating the net benefit of ...
Geneviève Chêne, Rodolphe Thiébaut
doaj   +1 more source

Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]

, 2013
Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa, Appolinary Ar, Silumbe, Richard   +1 more
core   +2 more sources

Methylene blue inhibits lumefantrine-resistant Plasmodium berghei

Journal of Infection in Developing Countries, 2016
Introduction: Chemotherapy still is the most effective way to control malaria, a major public health problem in sub-Saharan Africa. The large-scale use of the combination therapy artemether-lumefantrine for malaria treatment in Africa predisposes ...
Victor Irungu Mwangi, Ruth Mwende Mumo, Daniel Muthui Kiboi, Sabah Ahmed Omar, Zipporah Waithera Ng'ang'a, Hastings Suba Ozwara   +5 more
doaj   +1 more source

In Vitro Inhibitory Activity of Corilagin and Punicalagin Against Toxoplasma gondii and Their Mechanism(s) of Action

Antibiotics
Background/Objectives: Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii. The parasite infection in humans continues to rise due to an increasing seroprevalence rate in domestic and wild warm-blooded animals that serve as a major reservoir ...
Nicole T. Green-Ross, Homa Nath Sharma, Audrey Napier, Boakai K. Robertson, Robert L. Green, Daniel A. Abugri   +5 more
doaj   +1 more source

Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.

, 2009
Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective ...
Cairns, Matthew, Gosling, Roly, Gesase, Samwel, Mosha, Jacklin, Greenwood, Brian, Chandramohan, Daniel   +5 more
core   +1 more source

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources

Audit of failure rate of sulfadoxine/pyrimetham combined with chloroquine to treat falciparum malaria at single fourteen-day follow-up

South African Family Practice, 2002
Objective: To assess the failure rate of the present first line treatment regime for uncomplicated falciparum malaria of sulfadoxine/pyrimethamine combined with chloroquine. Design: A before-after study. Setting: Ndumo Clinic, Ingwavuma District, South
C.H. Vaughan Williams, C. La Cock, G.F.J. Henry, A.J. Ross   +3 more
doaj   +1 more source

Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children

Memorias do Instituto Oswaldo Cruz, 2006
The effects of pyrimethamine-sulphadoxine (PS), chloroquine plus chlorpheniramine, a H1 receptor antagonist that reverses chloroquine resistance in Plasmodium falciparum in vitro and in vivo (CQCP), and amodiaquine plus pyrimethamine-sulphadoxine (AQPS ...
A Sowunmi, AA Adedeji, GO Gbotosho, BA Fateye, TC Happi   +4 more
doaj   +1 more source