Options for clinical trials of pre and post-natal treatments for congenital toxoplasmosis
Clinical trials comparing different drug regimens and strategies for the treatment of congenital toxoplasmosis and its clinical manifestations in the liveborn child in different clinical settings should aim at formally evaluating the net benefit of ...
Geneviève Chêne, Rodolphe Thiébaut
doaj +1 more source
Prospective evaluation of BDProbeTec strand displacement amplification (SDA) system for diagnosis of tuberculosis in non-respiratory and respiratory samples. [PDF]
Nucleic acid amplification techniques (NAATs) have been demonstrated to make significant improvements in the diagnosis of tuberculosis (TB), particularly in the time to diagnosis and the diagnosis of smear-negative TB. The BD ProbeTec strand displacement
Billington, OJ +7 more
core +2 more sources
Efficacy of sulphadoxine-pyrimethamine + artesunate, sulphadoxine-pyrimethamine + amodiaquine, and sulphadoxine-pyrimethamine alone in uncomplicated falciparum malaria in Mali [PDF]
Plasmodium falciparum resistance to artemisinin has been reported in South-East Asia. Long half-life drugs are increasingly being used for malaria prevention. The potential spread of parasite resistance to these regimens is real and makes regular efficacy surveillance a priority.From August to December 2004 and July to December 2005, a randomized open ...
Abdoul H. Beavogui +15 more
openaire +3 more sources
Adverse Event Profile of Pyrimethamine-Based Therapy in Toxoplasmosis: A Systematic Review
IntroductionApproximately a third of the population worldwide is chronically infected with Toxoplasma gondii. Pyrimethamine-based regimens are recommended for the treatment of toxoplasmosis.ObjectiveThe aim was to evaluate the safety profile of ...
R. R. Ben-Harari, E. Goodwin, J. Casoy
semanticscholar +1 more source
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld +23 more
wiley +2 more sources
Gametocitemia en malaria por Plasmodium falciparum tratada con amodiaquina o artesunato
Introducción. Las relaciones de la gametocitemia de Plasmodium falciparum con el tratamiento antipalúdico han sido poco estudiadas en América. Objetivo.
Jaime Carmona-Fonseca +2 more
doaj +1 more source
Introducción. La disminución de la eficacia de los medicamentos antipalúdicos en el mundo y en Colombia, dificulta el control de la enfermedad. Objetivo.
Manuel Alberto Pérez +5 more
doaj +1 more source
The loop-mediated isothermal amplification coupled with lateral flow dipstick (PfSNP-LAMP-LFD) was recently developed to detect single nucleotide polymorphism (AAT → ATT), corresponding to substitution of asparagine to isoleucine at amino acid position ...
Suganya Yongkiettrakul +9 more
doaj +1 more source
Decreasing burden of malaria in pregnancy in Malawian women and its relationship to use of intermittent preventive therapy or bed nets. [PDF]
The World Health Organization recommends insecticidal bednets and intermittent preventive treatment to reduce malaria in pregnancy. Longitudinal data of malaria prevalence and pregnancy outcomes are valuable in gauging the impact of these antimalarial ...
Gaoqian Feng +4 more
doaj +1 more source
Sulphadoxine and pyrimethamine (SP) have been used as long-acting partner antimalarial drugs in artemisinin combination therapy (ACT) for falciparum malaria.
Madhvi Chahar, A. Anvikar, N. Valecha
semanticscholar +1 more source

