Results 41 to 50 of about 9,568 (92)

Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine

Pharmacology Research & Perspectives, 2017
Metformin is a common co‐medication for many diseases and the victim of clinical drug‐drug interactions (DDIs) perpetrated by cimetidine, trimethoprim and pyrimethamine, resulting in decreased active renal clearance due to inhibition of organic cation ...
R. Elsby, Stephen Chidlaw, Samuel N. Outteridge, Sarah Pickering, A. Radcliffe, Rebecca Sullivan, H. Jones, P. Butler   +7 more
semanticscholar   +1 more source

Altered life history strategies protect malaria parasites against drugs

Evolutionary Applications, 2018
Drug resistance has been reported against all antimalarial drugs, and while parasites can evolve classical resistance mechanisms (e.g., efflux pumps), it is also possible that changes in life history traits could help parasites evade the effects of ...
Philip L. G. Birget, Megan A. Greischar, Sarah E. Reece, Nicole Mideo   +3 more
doaj   +1 more source

The use of long acting sulfonamides, alone or with pyrimethamine, in malaria (with special reference to sulformetoxine)

Revista da Sociedade Brasileira de Medicina Tropical, 1967
Review of the early literature as well as more recent results show that sulfonamides possess a distinct antimalarial activity. However, when give alone, their action is less marked and slower than that of the antimalarials commonly used in the treatment ...
J. Herrero
doaj   +1 more source

Pharmacokinetics of Sulfadoxine and Pyrimethamine for Intermittent Preventive Treatment of Malaria During Pregnancy and After Delivery

CPT: Pharmacometrics & Systems Pharmacology, 2017
Sulfadoxine/pyrimethamine is recommended for intermittent preventative treatment of malaria during pregnancy. Data from 98 women during pregnancy and 77 after delivery in four African countries were analyzed using nonlinear mixed‐effects modeling to ...
M. D. Kock, J. Tarning, Lesley J. Workman, M. M. Nyunt, I. Adam, Karen I. Barnes, P. Denti   +6 more
semanticscholar   +1 more source

Adding artesunate to sulphadoxine-pyrimethamine greatly improves the treatment efficacy in children with uncomplicated falciparum malaria on the coast of Benin, West Africa

Malaria Journal, 2007
Background Benin has recently shifted its national antimalarial drug policy from monotherapies to combinations containing artemisinin derivatives. When this decision was taken, the available information on alternatives to chloroquine and sulphadoxine ...
Coosemans Marc, Akogbeto Martin, Menten Joris, van Loen Harry, Van Overmeir Chantal, Agbowai Carine, Gazard Dorothée, Erhart Annette, Nahum Alain, Massougbodji Achille, D'Alessandro Umberto   +10 more
doaj   +1 more source

Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

Annals of Neurology, 2017
Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1‐transgenic animal models. Pyrimethamine produces dose‐dependent SOD1 reduction in cell culture systems.
D. Lange, Mona Shahbazi, V. Silani, A. Ludolph, Jochen H Weishaupt, S. Ajroud-Driss, K. Fields, Rahul Remanan, S. Appel, C. Morelli, A. Doretti, L. Maderna, S. Messina, Ulrike Weiland, S. Marklund, P. Andersen   +15 more
semanticscholar   +1 more source

Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone

Memorias do Instituto Oswaldo Cruz, 2001
Chloroquine has been the mainstay of malaria chemotherapy for the past five decades, but resistance is now widespread. Pyrimethamine or proguanil form an important component of some alternate drug combinations being used for treatment of uncomplicated ...
Ravi Toteja, Lathika Nair, VK Bhasin
doaj   +1 more source

Toxoplasmic encephalitis relapse rates with pyrimethamine-based therapy: systematic review and meta-analysis

Pathogens and Global Health, 2017
Toxoplasmic encephalitis (TE) is caused by Toxoplasma gondii infection and can be a life-threatening disease in immunocompromised patients. This study evaluated the rate of relapse associated with pyrimethamine-based maintenance therapy (i.e.
M. Connolly, E. Goodwin, C. Schey, J. Zummo   +3 more
semanticscholar   +1 more source

Frequency of Pfcrt T76 and Pfdhfr Asn-108 Drug Resistance Mutations in falciparum Malaria in Southeastern Malaria Endemic Area of Iran [PDF]

Iranian Journal of Public Health, 2008
Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with re­sistance to chloroquine (CQ) and pyrimethamine, respectively.
MR Razavi, SR Naddaf, JLe Bras, A Raesi, AR Esmaeili, M Assmar   +5 more
doaj   +1 more source

Efficacy of pyrimethamine-sulfadoxine in young children with uncomplicated falciparum malaria in rural Burkina Faso

Malaria Journal, 2004
The efficacy of pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in young children of a malaria holoendemic area in rural Burkina Faso is reported.
Traore Corneille, Müller Olaf, Kouyate Bocar   +2 more
doaj   +1 more source