Results 41 to 50 of about 41,516 (300)

Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa

Scientific Reports, 2017
Intermittent preventive treatment (IPT) with sulphadoxine-pyrimethamine in vulnerable populations reduces malaria morbidity in Africa, but resistance mutations in the parasite dhps gene (combined with dhfr mutations) threaten its efficacy.
L. Okell, J. Griffin, C. Roper
semanticscholar   +1 more source

Perspective for the reproduction of antimalarial drugs in Brazil

Memorias do Instituto Oswaldo Cruz, 1992
The appears to be no chemical manufacture of antimalarial drugs is Brazil. Technology at laboratory process level has been developed for chloroquine, mefloquine, pyrimethamine and cycloquanil, but not perfected nor scaled-up, largely for economic reasons
Benjamin Gilbert
doaj   +1 more source

Are transnational tobacco companies' market access strategies linked to economic development models? A case study of South Korea. [PDF]

, 2013
Transnational tobacco companies (TTCs) have used varied strategies to access previously closed markets. Using TTCs' efforts to enter the South Korean market from the late 1980s as a case study, this article asks whether there are common patterns in these
Amon, A, Asgari, M, Blake, C, Choi, A, Erben, T, Glazebrook, K, Harnois-Déraps, J, Heymans, C, Hildebrandt, H, Hoekstra, H, Johnson, A, Joudaki, S, Klaes, D, Kuijken, K, Lidman, C, Mead, A, Miller, L, Parkinson, D, Poole, GB, Schneider, P, Viola, M, Wolf, C   +21 more
core   +6 more sources

Community-based Malaria Screening and Treatment for Pregnant Women Receiving Standard Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine: A Multicenter (The Gambia, Burkina Faso, and Benin) Cluster-randomized Controlled Trial

Clinical Infectious Diseases, 2018
Adding community-based scheduled malaria screening and treatment to existing intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) strategies did not reduce malaria in pregnancy.
Susana Umberto Lindsay John Kalifa Simon Fanta Halidou Ma Scott D’Alessandro Kendall Bradley Bojang Correa N, S. Scott, U. d’Alessandro, L. Kendall, J. Bradley, K. Bojang, Simon Correa, F. Njie, H. Tinto, M. Traoré-Coulibaly, H. M. Natama, O. Traoré, I. Valéa, A. Nahum, Daniel Ahounou, Francis Bohissou, G. Sondjo, Carine Agbowai, P. Mens, E. Ruizendaal, H. Schallig, Susan Dierickx, K. P. Grietens, L. Duval, L. Conteh, M. Drabo, J. Guth, F. Pagnoni   +27 more
semanticscholar   +1 more source

Options for clinical trials of pre and post-natal treatments for congenital toxoplasmosis

Memorias do Instituto Oswaldo Cruz, 2009
Clinical trials comparing different drug regimens and strategies for the treatment of congenital toxoplasmosis and its clinical manifestations in the liveborn child in different clinical settings should aim at formally evaluating the net benefit of ...
Geneviève Chêne, Rodolphe Thiébaut
doaj   +1 more source

Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.

, 2001
Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit.
Targett, G, Drakeley, C, Jawara, M, von Seidlein, L, Coleman, R, Deen, J, Pinder, M, Doherty, T, Sutherland, C, Walraven, G, Milligan, P   +10 more
core   +1 more source

Potentiating effect of pyrimethamine and sulfadoxine against dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi

Antimicrobial Agents and Chemotherapy, 1986
Dihydrofolate reductase was partially purified from a pyrimethamine-sensitive Plasmodium chabaudi clone and a pyrimethamine-resistant clone derived from it and used in a study of the inhibitory effect of pyrimethamine and sulfadoxine, both alone and in combination.
Worachart Sirawaraporn, Yongyuth Yuthavong   +1 more
openaire   +4 more sources

Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment. [PDF]

, 2007
Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115) or three (n = 117) days artesunate (1AS, 3AS 4 mg/kg/day) plus ...
Adjuik, Adjuik, Basco, Basco, Brockman, Cattamanchi, Farnert, Felger, Gil, Happi, Irion, Magesa, Obonyo, Priotto, Ranford-Cartwright, Sirima, Snounou, Snounou, Von Seidlein, White, WHO, WHO, WHO   +22 more
core   +2 more sources

Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in the Democratic Republic of the Congo: emergence of highly resistant pfdhfr/pfdhps alleles

Journal of Antimicrobial Chemotherapy, 2018
Background In 2005, the Democratic Republic of the Congo (DRC) switched to artesunate/amodiaquine as the first-line antimalarial in response to increasing sulfadoxine/pyrimethamine resistance and adopted intermittent preventive treatment using ...
P. Nkoli Mandoko, Florent Rouvier, Lebon Matendo Kakina, D. Moke Mbongi, Christine Latour, J. Losimba Likwela, D. Ngoyi Mumba, S. K. Bi Shamamba, Jean-Jacques Tamfum Muyembe, L. Muepu Tshilolo, D. Parzy, V. Sinou   +11 more
semanticscholar   +1 more source

Efficacy of sulfadoxine-pyrimethamine in Tanzania after two years as first-line drug for uncomplicated malaria: assessment protocol and implication for treatment policy strategies. [PDF]

, 2005
BACKGROUND\ud \ud Systematic surveillance for resistant malaria shows high level of resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) across eastern and southern parts of Africa. This study assessed in vivo SP efficacy after two years
Abdulla, Salim, Beck, Hans-Peter, Falk, Nicole, Felger, Ingrid, Genton, Blaise, Masanja, Honorati, Mshinda, Hassan, Mugittu, Kefas   +7 more
core   +3 more sources