Results 41 to 50 of about 42,597 (297)

Mutaciones puntuales en los genes dhfr y dhps de Plasmodium falciparum de tres regiones endémicas

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. La acumulación progresiva de mutaciones en los genes dhfr y dhps lleva al parásito Plasmodium falciparum a evadir la acción de la sulfadoxina-pirimetamina, situación que aumenta el nivel de resistencia del parásito a estos medicamentos y ...
John Alexander Galindo, Fabio Aníbal Cristiano, Angélica Knudson, Rubén Santiago Nicholls, Ángela Patricia Guerra   +4 more
doaj   +1 more source

Perspective for the reproduction of antimalarial drugs in Brazil

Memorias do Instituto Oswaldo Cruz, 1992
The appears to be no chemical manufacture of antimalarial drugs is Brazil. Technology at laboratory process level has been developed for chloroquine, mefloquine, pyrimethamine and cycloquanil, but not perfected nor scaled-up, largely for economic reasons
Benjamin Gilbert
doaj   +1 more source

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. [PDF]

, 2008
BACKGROUND: Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and ...
Bousema, Teun, Drakeley, Chris J, Ghani, Azra C, Okell, Lucy C, Sutherland, Colin J   +4 more
core   +3 more sources

Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa

Scientific Reports, 2017
Intermittent preventive treatment (IPT) with sulphadoxine-pyrimethamine in vulnerable populations reduces malaria morbidity in Africa, but resistance mutations in the parasite dhps gene (combined with dhfr mutations) threaten its efficacy.
L. Okell, J. Griffin, C. Roper
semanticscholar   +1 more source

A new effective antiplasmodial compound: Nanoformulated pyrimethamine

Journal of Global Antimicrobial Resistance, 2020
Objectives: The aim of this study was to evaluate the efficacy of pyrimethamine-loaded poloxamer 407 nanomicelles on Plasmodium berghei strain NICD in vivo.
Nader Pestehchian, Mohammad Reza Vafaei, Pardis Nematolahy, Jaleh Varshosaz, Hossein Ali Yousefi, Vahab Ziaei Bide, Hamed Kalani   +6 more
doaj   +1 more source

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Coulibaly, Boubacar, Klose, Christina, Kouyaté, Bocar, Mansmann, Ulrich, Meissner, Peter E., Mockenhaupt, Frank P., Müller, Olaf, Schirmer, R. Heiner, Sié, Ali, Walter-Sack, Ingeborg, Zoungrana, Augustin   +10 more
core   +1 more source

Molecular markers of resistance to amodiaquine plus sulfadoxine–pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Malaria Journal, 2018
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrimethamine (AQ + SP) is recommended in the ...
R. Grais, I. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, C. Langendorf, A. Amambua-Ngwa, U. d’Alessandro, P. Guérin, T. Fandeur, C. Sibley   +10 more
semanticscholar   +1 more source

Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres

Pathogens
During pregnancy, primary Toxoplasma gondii infection can cause congenital toxoplasmosis (CT). We described the newborns’ outcomes from a multicentre cohort of mothers with seroconversion (SC) at different gestational ages.
Alice Bonetti, Agnese Comelli, Annacarla Chiesa, Vania Spinoni, Ambra Vola, Federico Prefumo, Adriana Valcamonico, Carlo Bonfanti, Silvio Caligaris, Lina Rachele Tomasoni, Fausto Baldanti, Valeria Meroni   +11 more
doaj   +1 more source

Community-based Malaria Screening and Treatment for Pregnant Women Receiving Standard Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine: A Multicenter (The Gambia, Burkina Faso, and Benin) Cluster-randomized Controlled Trial

Clinical Infectious Diseases, 2018
Adding community-based scheduled malaria screening and treatment to existing intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) strategies did not reduce malaria in pregnancy.
Susana Umberto Lindsay John Kalifa Simon Fanta Halidou Ma Scott D’Alessandro Kendall Bradley Bojang Correa N, S. Scott, U. d’Alessandro, L. Kendall, J. Bradley, K. Bojang, Simon Correa, F. Njie, H. Tinto, M. Traoré-Coulibaly, H. M. Natama, O. Traoré, I. Valéa, A. Nahum, Daniel Ahounou, Francis Bohissou, G. Sondjo, Carine Agbowai, P. Mens, E. Ruizendaal, H. Schallig, Susan Dierickx, K. P. Grietens, L. Duval, L. Conteh, M. Drabo, J. Guth, F. Pagnoni   +27 more
semanticscholar   +1 more source

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children. [PDF]

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
A Yeka, B Greenhouse, CH Sibley, E Depoortere, Eleanor Turyakira, Elizabeth A Ashley, F Grandesso, Francesco Checchi, Grant Dorsey, H Bukirwa, Hasifa Bukirwa, I van den Broek, I Zongo, I Zongo, Ingrid van den Broek, Issaka Zongo, Jean-Paul Guthmann, JP Guthmann, JP Guthmann, JP Guthmann, K Mugittu, K Mugittu, K Stepniewska, K Stepniewska, Loretxu Pinoges, M Bonnet, Michel van Herp, N Bakyaita, NJ White, Pedro Pablo Palma Urruta, Piero Olliaro, PO Olliaro, RN Price, S Hamour, SG Staedke, Suna Balkan, TD Swarthout, Walter R Taylor, WJ Collins, World Health Organization, World Health Organization, World Health Organization, World Health Organization, World Health Organization   +43 more
core   +5 more sources