Results 11 to 20 of about 314,968 (285)
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which the prognosis is determined by liver fibrosis.
P. Luukkonen +17 more
semanticscholar +1 more source
Nature Communications, 2022 The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chemical models and laboratory experiments have predicted that these compounds can also be produced from chemical precursors found in meteorites.
Y. Oba +6 more
semanticscholar +1 more source
Nature Biotechnology, 2022 Directed evolution creates new compact Cas9 variants that target most single pyrimidine nucleotide PAMs. Despite the availability of Cas9 variants with varied protospacer-adjacent motif (PAM) compatibilities, some genomic loci—especially those with ...
Tony P. Huang +7 more
semanticscholar +1 more source
Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy
Cells, 2022 Nucleotides are synthesized through two distinct pathways: de novo synthesis and nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino acids and glucose, the salvage pathway recovers nucleosides or bases formed during DNA or ...
M. Walter, P. Herr
semanticscholar +1 more source
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine
Frontiers in Oncology, 2021 Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell survival and growth.
Wanyan Wang +4 more
semanticscholar +1 more source
Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms [PDF]
, 2013 <p>Background: African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.</p> <p>Methodology/Principal ...
A Hofer +51 more
core +6 more sources
Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity
Nature Metabolism, 2021 Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic.
Hans-Georg Sprenger +12 more
semanticscholar +1 more source
Pyrimidine: a review on anticancer activity with key emphasis on SAR
Future Journal of Pharmaceutical Sciences, 2021 Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra +2 more
semanticscholar +1 more source
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
bioRxiv, 2021 Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones that do not readily lend themselves to drug development.
Sharmistha Pal +15 more
semanticscholar +1 more source
ACS Omega, 2021 A class of pyrimidine thioglycoside analogs (6a–h) were synthesized from a reaction of 2-cyano-3,3-dimercapto-N-arylacrylamide (2a–d) and thiourea to produce the corresponding 4-amino-2-mercapto-N-arylpyrimidine-5-carboxamide derivatives (3a–d), and ...
M. Abu-Zaied, G. Elgemeie, N. Mahmoud
semanticscholar +1 more source