Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity
Nature Metabolism, 2021 Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic.
Hans-Georg Sprenger +12 more
semanticscholar +1 more source
Pyrimidine: a review on anticancer activity with key emphasis on SAR
Future Journal of Pharmaceutical Sciences, 2021 Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra +2 more
semanticscholar +1 more source
Synthesis of various fused pyrimidine rings with their pharmacological and antimicrobial evaluation [PDF]
Journal of the Serbian Chemical Society, 2014 Various fused pyrimidine such as furo[2,3-d]pyrimidine, triazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine were synthesized from the reactions of thioxopyrimidine-6(1H)-ones with ethyl chloroacetate (under different reaction conditions ...
Mounir Salem A. +2 more
doaj +1 more source
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
bioRxiv, 2021 Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones that do not readily lend themselves to drug development.
Sharmistha Pal +15 more
semanticscholar +1 more source
Synthesis, characterization and theoretical studies of novel pyrimidine derivatives as potential corrosion inhibitors [PDF]
Journal of the Serbian Chemical Society, 2020 In this study, five new pyrimidine derivatives were synthesized and characterized by characterization methods such as 1H-NMR, 13C-NMR, FT- -IR and elemental analysis.
Akbas Esvet, Yildiz Ela, Erdogan Ahmet
doaj +1 more source
Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances
Frontiers in Chemistry, 2021 In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies.
Muhammad Faisal, Aamer Saeed
doaj +1 more source
ACS Omega, 2021 A class of pyrimidine thioglycoside analogs (6a–h) were synthesized from a reaction of 2-cyano-3,3-dimercapto-N-arylacrylamide (2a–d) and thiourea to produce the corresponding 4-amino-2-mercapto-N-arylpyrimidine-5-carboxamide derivatives (3a–d), and ...
M. Abu-Zaied, G. Elgemeie, N. Mahmoud
semanticscholar +1 more source
Molecules, 2020 A series of 34 new pyrimido[2,1-c][1,2,4]triazine-3,4-diones were synthesized and fully characterized using IR, NMR, MS, and microanalytical analysis. In vitro investigation of 12 compounds of this series revealed promising antimicrobial activity of the ...
Islam H. El Azab, Nadia A.A. Elkanzi
doaj +1 more source
Synthesis of Pyrimidines and Condensed Pyrimidines [PDF]
Bulletin of the Chemical Society of Japan, 1973 Abstract A new one-step synthesis of pyrimidines and condensed pyrimidines by heating carboxamides or cyclic lactams with formamide in the presence of POCl3 in a sealed tube is described.
openaire +3 more sources
Design, synthesis and antitumor activity of coumarin, isoxazole, pyrazole, pyridine and pyrimidine compounds: 3β-hydroxypregn-5-ene-20-one derivatives [PDF]
Acta Poloniae Pharmaceutica, 2023 In continuation of our reserach for synthesizing heterocyclic derivatives with a broad range of biological activities, the current research was performed to synthesize 3β-hydroxypregn-5-ene-20-one derivatives of coumarin, isoxazole, pyrazole, pyridine ...
Karam A. El-Sharkawy +6 more
doaj +1 more source