Results 11 to 20 of about 290,598 (376)

Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

open access: yesNature Metabolism, 2021
Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic.
Hans-Georg Sprenger   +12 more
semanticscholar   +1 more source

Pyrimidine: a review on anticancer activity with key emphasis on SAR

open access: yesFuture Journal of Pharmaceutical Sciences, 2021
Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents.
Aastha Mahapatra   +2 more
semanticscholar   +1 more source

Synthesis of various fused pyrimidine rings with their pharmacological and antimicrobial evaluation [PDF]

open access: yesJournal of the Serbian Chemical Society, 2014
Various fused pyrimidine such as furo[2,3-d]pyrimidine, triazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine were synthesized from the reactions of thioxopyrimidine-6(1H)-ones with ethyl chloroacetate (under different reaction conditions ...
Mounir Salem A.   +2 more
doaj   +1 more source

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

open access: yesbioRxiv, 2021
Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones that do not readily lend themselves to drug development.
Sharmistha Pal   +15 more
semanticscholar   +1 more source

Synthesis, characterization and theoretical studies of novel pyrimidine derivatives as potential corrosion inhibitors [PDF]

open access: yesJournal of the Serbian Chemical Society, 2020
In this study, five new pyrimidine derivatives were synthesized and characterized by characterization methods such as 1H-NMR, 13C-NMR, FT- -IR and elemental analysis.
Akbas Esvet, Yildiz Ela, Erdogan Ahmet
doaj   +1 more source

Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances

open access: yesFrontiers in Chemistry, 2021
In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies.
Muhammad Faisal, Aamer Saeed
doaj   +1 more source

Anti-Covid-19 Drug Analogues: Synthesis of Novel Pyrimidine Thioglycosides as Antiviral Agents Against SARS-COV-2 and Avian Influenza H5N1 Viruses

open access: yesACS Omega, 2021
A class of pyrimidine thioglycoside analogs (6a–h) were synthesized from a reaction of 2-cyano-3,3-dimercapto-N-arylacrylamide (2a–d) and thiourea to produce the corresponding 4-amino-2-mercapto-N-arylpyrimidine-5-carboxamide derivatives (3a–d), and ...
M. Abu-Zaied, G. Elgemeie, N. Mahmoud
semanticscholar   +1 more source

Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-c][1,2,4]triazolo[3,4-f][1,2,4]triazines

open access: yesMolecules, 2020
A series of 34 new pyrimido[2,1-c][1,2,4]triazine-3,4-diones were synthesized and fully characterized using IR, NMR, MS, and microanalytical analysis. In vitro investigation of 12 compounds of this series revealed promising antimicrobial activity of the ...
Islam H. El Azab, Nadia A.A. Elkanzi
doaj   +1 more source

Synthesis of Pyrimidines and Condensed Pyrimidines [PDF]

open access: yesBulletin of the Chemical Society of Japan, 1973
Abstract A new one-step synthesis of pyrimidines and condensed pyrimidines by heating carboxamides or cyclic lactams with formamide in the presence of POCl3 in a sealed tube is described.
openaire   +3 more sources

Design, synthesis and antitumor activity of coumarin, isoxazole, pyrazole, pyridine and pyrimidine compounds: 3β-hydroxypregn-5-ene-20-one derivatives [PDF]

open access: yesActa Poloniae Pharmaceutica, 2023
In continuation of our reserach for synthesizing heterocyclic derivatives with a broad range of biological activities, the current research was performed to synthesize 3β-hydroxypregn-5-ene-20-one derivatives of coumarin, isoxazole, pyrazole, pyridine ...
Karam A. El-Sharkawy   +6 more
doaj   +1 more source

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