Results 191 to 200 of about 314,968 (285)

<i>p</i>TSA-catalyzed synthesis of functionalized chromeno[2,3-<i>d</i>]pyrimidine/chromeno[4,3-<i>b</i>]chromene derivatives <i>via</i> one-pot three component reaction: mechanistic insights and variable temperature NMR studies to investigate restricted bond rotation. [PDF]

RSC Adv
Singh Tanwer YB, Sourabh S, Bhunia S, Pal S, Das D.   +4 more
europepmc   +1 more source

The gut microbiome associated with LGI1‐antibody encephalitis

Epilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis is a cause of brain inflammation characterized by auto‐antibodies, which target cell surface neuronal proteins and lead to neuronal dysfunction. The most common form is associated with auto‐antibodies to leucine‐rich glioma‐inactivated 1 (LGI1) protein, the presentation of which includes frequent focal ...
Edmund Gilbert, Sophie Binks, Valentina Damato, Christopher Uy, Paula Colmenero, Mark Kelly, Mohamed Ibrahim Khalil, Marcus O'Brien, Marcus J Claesson, John F. Cryan, Norman Delanty, Sarosh R. Irani, Gianpiero L. Cavalleri   +12 more
wiley   +1 more source

Innovative Amino-Functionalization of Pyrido[2,3-<i>d</i>]pyrimidine Scaffolds for Broad Therapeutic Applications Supported by Computational Analyses. [PDF]

Pharmaceuticals (Basel)
El-Hema HS, Shehata HE, Hawata MA, Nossier ES, El-Sayed AF, Altwaijry NA, Saleh A, Hussein MF, Sabry A, Abdel-Rahman AA.   +9 more
europepmc   +1 more source

A kinetic and nuclear magnetic resonance study of methylated pyrimidine nucleosides [PDF]

, 1983
Brian Allore, A. Queen, Wayne J. P. Blonski, Frank E. Hruska   +3 more
openalex   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

5-Amino- and 6-amino-uracils in the synthesis of various heterocycles as therapeutic agents: a review. [PDF]

RSC Adv
Aly AA, Osman EM, Mostafa SM, Bedair TM, Abd-Elmonem M, Sadek KU, Mohamed AH.   +6 more
europepmc   +1 more source

A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization.

Nature Chemistry, 2017
Jianfeng Xu, Maria Tsanakopoulou, Christopher J. Magnani, Rafał Szabla, J. Šponer, J. Šponer, R. Góra, J. Sutherland   +7 more
semanticscholar   +1 more source

Heterologous plastoquinone production using a newly identified O2‐dependent cyanobacterial hydroxylase

The FEBS Journal, EarlyView.
In this study, we confirm that PlqH is the hydroxylase operating in plastoquinone biosynthesis in photosynthetic cyanobacteria (Cyanobacteriia). Our phylogenetic analyses demonstrate that cyanobacterial PlqH homologues originated from hydroxylases involved in ubiquinone biosynthesis in bacteria. Plastoquinone production in Escherichia coli was achieved
Morgane Roger‐Margueritat, Margot Beltran, Juliette Schnoebelen, Laura Flandrin, Wafa Rezali, Eline Michel, Sophie S. Abby, Fabien Pierrel   +7 more
wiley   +1 more source

Synthesis of 5-substituted [N3-15N]-pyrimidine nucleosides: Developing model systems for NMR studies of substituent effects on the N-H{middle dot}{middle dot}{middle dot}N hydrogen bond in duplex DNA [PDF]

, 2001
Ryuta Ishikawa, Chojiro Kojima, Akira Ono, Masatsune Kainosho   +3 more
openalex   +1 more source

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, EarlyView.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source