Results 191 to 200 of about 151,536 (281)

INHBA promotes chemoresistance in pancreatic cancer by enhancing CTPS1 stability and mediating pyrimidine metabolism. [PDF]

Cancer Cell Int
Sun X, Wei Z, Liao X, Zheng D, Li F, Chen L, Gong Y, Ran S, Han X, He Z, Yu C.   +10 more
europepmc   +1 more source

Analogs of a 4-aminothieno[2,3-d]pyrimidine lead (QB13) as modulators of P-glycoprotein substrate specificity

, 2009
Hans-Georg Häcker, Antje de la Haye, Katja Sterz, Gregor Schnakenburg, Michael Wiese, Michael Gütschow   +5 more
openalex   +1 more source

Alloxazine derivatives as multifunctional agents for photodynamic therapy, cancer cell imaging, and cell proliferation inhibition

Photochemistry and Photobiology, EarlyView.
Alloxazine photosensitizers, molecularly engineered through sugar conjugation and methoxy substitution to enhance solubility, photodynamic potency, and fluorescence, enable image‐guided photodynamic therapy while inhibiting cancer cell growth in the absence of photoactivation.
Rubej R. Khan, Sourav Kanti Seth, Reshma Mathew, Nitza V. Falcón‐Cruz, Chris Acquah, Steffen Jockusch, Liraz Levi, Carlos E. Crespo‐Hernández   +7 more
wiley   +1 more source

African swine fever virus hijacks host pyrimidine metabolism to promote viral replication. [PDF]

J Virol
Song Z, Chen Y, Guo H, Zhang G, Gong L, Zheng Z.   +5 more
europepmc   +1 more source

Deciphering the role of HD52, a mitochondrial nucleotidase essential for pyrimidine homeostasis in Trypanosoma brucei

, 2019
Miriam Yagüe-Capilla, VM Castillo-Acosta, María Valente, Cristina Bosch‐Navarrete, Luis M. Ruiz‐Pérez, Dolores González‐Pacanowska   +5 more
openalex   +1 more source

Investigation of 222‐nm ultraviolet C irradiation bactericidal effect on the surgical field in a rabbit model

Photochemistry and Photobiology, EarlyView.
In a rabbit surgical field model seeded with polymicrobial flora, a single dose of 222‐nm UV‐C (500 mJ/cm2) markedly reduced bacterial colonies, achieving a bactericidal effect comparable to 254‐nm UV‐C (200 mJ/cm2), while no UV‐C irradiation showed heavy growth. Wound healing did not differ among groups. Microbiota profiling detected SSI‐relevant taxa
Tomoaki Fukui, Yuya Yamamoto, Kyohei Takase, Keisuke Oe, Kenichi Sawauchi, Ryota Nishida, Takahiro Niikura, Rena Kaigome, Masahiro Sasaki, Toru Koi, Hiroyuki Ohashi, Ryosuke Kuroda   +11 more
wiley   +1 more source

Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation. [PDF]

Nat Commun
Endaya BB, Kučera L, Le DT, Spinelli JB, Brožková A, Luptáková D, Klíma K, Oliveira GL, Brisudová P, Boháčová K, Boukalová Š, Zobalová R, Kolář F, Chalupsky K, Dohnalová K, Yarmohammadi-Barzegar A, Dvořáková Š, Biryukova E, Kaliaeva M, Havlíček V, Sedláček R, Procházka J, Vítek L, Park S, Martásek P, Krška Z, Oliveira PJ, Berridge MV, Neužil J.   +28 more
europepmc   +1 more source

A simple and expedient protocol for the formation of furan-fused pyrimidine-containing phenol via a constructive multicomponent reaction under ambient conditions

Mahmoud Nassiri, Jaber Salehzadeh, Zahra Dehghani, Parisa Babaei   +3 more
openalex   +1 more source

Synthesis and Antibacterial Activity of Pinanyl-2-amino Pyrimidines

, 2014
Jun Wu, Peng-Na Wang, Xu Xu, Yiqin Yang, Shifa Wang   +4 more
openalex   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source