On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily
Angewandte Chemie International Edition, Volume 65, Issue 4, 22 January 2026.Comprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
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