The continuing significance of chiral agrochemicals
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Studies on Synthetic Nucleosides. I. Trimethylsilyl Derivatives of Pyrimidines and Purines.
Takuzo Nishimura, Issei Iwai
openalex +2 more sources
Design, synthesis, <i>in silico</i> studies and antiproliferative evaluation of some novel hybrids of pyrimidine-morpholine. [PDF]
Ataollahi E+9 more
europepmc +1 more source
Influence of Cosolvents on the Pressure Stability of Human Serum Albumin
Human serum albumin is able to bind various hydrophobic substances and drugs. To investigate this interaction, the protein structure is analyzed using small‐angle X‐ray scattering under high hydrostatic pressure. The resulting radius of gyration (see picture) indicates that hydrophobic substances influence the pressure stability of HSA differently ...
Jaqueline Savelkouls+3 more
wiley +1 more source
Antibiofilm Activities of Halogenated Pyrimidines Against Enterohemorrhagic <i>Escherichia coli</i> O157:H7. [PDF]
Jeon H, Kim YG, Lee JH, Lee J.
europepmc +1 more source
Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections
This review critically evaluates fluorescent antibiotics as promising agents combining diagnostic precision with therapeutic efficacy. It highlights advances in probe design, chemical conjugation strategies, real‐time imaging applications, selective pathogen detection, and targeted therapy. The potential to combat antimicrobial resistance is discussed,
Tan Phuoc Ton+3 more
wiley +1 more source
Oxazolo[5,4-<i>d</i>]pyrimidines as Anticancer Agents: A Comprehensive Review of the Literature Focusing on SAR Analysis. [PDF]
Sochacka-Ćwikła A, Mączyński M.
europepmc +1 more source
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou+8 more
wiley +1 more source
Catalytic application of a bimetallic-organic framework with phosphorus acid groups in the preparation of pyrido[2,3-<i>d</i>]pyrimidines <i>via</i> cooperative vinylogous anomeric-based oxidation. [PDF]
Ataee-Najari AR+5 more
europepmc +1 more source