Recent Advances in Pyrimidine-Based Drugs
PharmaceuticalsPyrimidines have become an increasingly important core structure in many drug molecules over the past 60 years. This article surveys recent areas in which pyrimidines have had a major impact in drug discovery therapeutics, including anti-infectives ...
B. Nammalwar, R. Bunce
semanticscholar +1 more source
Purinergic Signalling Purinergic Signalling, 2020 Reprogramming of metabolism is described in many types of cancer and is associated with the clinical outcomes. However, the prognostic significance of pyrimidine metabolism signaling pathway in lung adenocarcinoma (LUAD) is unclear.
Haiwei Wang +4 more
semanticscholar +1 more source
The Ability of Cyanobacterial Cells to Restore UV-B Radiation Induced Damage to Photosystem II is Influenced by Photolyase Dependent DNA Repair [PDF]
, 2013 Damage of DNA and Photosystem-II are among the most significant effects of UV-B irradiation in photosynthetic organisms. Both damaged DNA and Photosystem-II can be repaired, which represent important defense mechanisms against detrimental UV-B effects ...
Kós, Péter +4 more
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Giant spin canting in the S = 1/2 antiferromagnetic chain [CuPM(NO3)2(H2O)2]n observed by 13C-NMR
, 2005 We present a combined experimental and theoretical study on copper pyrimidine dinitrate [CuPM(NO3)2(H2O)2]n, a one-dimensional S = 1/2 antiferromagnet with alternating local symmetry.
Brenig, W. +7 more
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De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. [PDF]
, 2014 The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences.
Black, Douglas L +5 more
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Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells
Science Translational Medicine, 2019 Concurrent targeting of pyrimidine synthesis and oncogenic driver pathways improves therapeutic efficacy in glioblastoma. Targeting metabolic changes in glioblastoma Glioblastoma (GBM) is the most aggressive brain cancer in adults.
Xiuxing Wang +21 more
semanticscholar +1 more source
Modulating pyrimidine ribonucleotide levels for the treatment of cancer
Cancer & Metabolism, 2020 By providing the necessary building blocks for nucleic acids and precursors for cell membrane synthesis, pyrimidine ribonucleotides are essential for cell growth and proliferation.
T. Mollick, S. Laín
semanticscholar +1 more source
Aquachlorido(2-{[6-(dimethylamino)pyrimidin-4- yl]sulfanyl}pyrimidine-4,6-diamine)copper(II) chloride hydrate [PDF]
, 2017 A copper(II) complex of the non-symmetric bidentate ligand 2-{[6-(dimethylamino)pyrimidin-4-yl]sulfanyl}pyrimidine-4,6-diamine (L1) is reported. The single-crystal X-ray structure of aqua[aqua/chlorido(0.49/0.51)](2-{[6-(dimethylamino)pyrimidin-
Chan, Weibin +4 more
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A Benchmark of GW Methods for Azabenzenes: Is the GW Approximation Good Enough?
, 2012 Many-body perturbation theory in the GW approximation is a useful method for describing electronic properties associated with charged excitations. A hierarchy of GW methods exists, starting from non-self-consistent G0W0, through partial self-consistency ...
Caruso, Fabio +8 more
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Chemical investigation of light induced DNA bipyrimidine damage and repair [PDF]
, 2011 In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage.
Carell, Thomas +2 more
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