Results 31 to 40 of about 197,991 (343)

Purine and pyrimidine nucleotide metabolism in Mollicutes

Genetics and Molecular Biology, 2007
Several mollicute genome projects are underway, offering unique opportunities to study genes and metabolic pathways on a genome-wide scale. Here, we have analyzed the conservation and diversity of purine and pyrimidine metabolism in mycoplasmas.
Cristiano Valim Bizarro, Desirée Cigaran Schuck   +1 more
doaj   +1 more source

Pyrimidine-2-carboxamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2007
In the crystal strucuture of the title compound, C(5)H(5)N(3)O, which was obtained upon recrystallization of 2-cyano-pyrimidine from aqueous sodium hydroxide, the amide group is twisted with respect to the aromatic ring by 24.9 (1)°. π-π stacking is observed between partially overlapped rings at a face-to-face separation of 3.439 (6) Å.
Jing-Jing Nie, Qian Yang, Bing-Yu Zhang
openaire   +3 more sources

Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network

Leukemia, 2020
Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid malignancies, require investigation and countermeasures. Both are nucleoside analog pro-drugs processed by pyrimidine metabolism into a deoxynucleotide analog that ...
X. Gu, R. Tohme, B. Tomlinson, Nneha Sakre, M. Hasipek, Lisa Durkin, Caroline Schuerger, D. Grabowski, Asmaa M. Zidan, T. Radivoyevitch, Changjin Hong, H. Carraway, B. Hamilton, R. Sobecks, B. Patel, B. Jha, E. Hsi, J. Maciejewski, Y. Saunthararajah   +18 more
semanticscholar   +1 more source

Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

Science, 2019
Conditions right for making nucleosides In the absence of biological catalysts and metabolism, can atmospheric and geochemical processes provide the substrates and conditions required for production of biological molecules? Becker et al.
S. Becker, Jonas Feldmann, Stefan Wiedemann, Hidenori Okamura, Christina Schneider, K. Iwan, Antony L. Crisp, M. Rossa, Tynchtyk Amatov, T. Carell   +9 more
semanticscholar   +1 more source

1-Methyl-3-(2-methylphenyl)-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine

IUCrData, 2017
In the title compound, C19H16N4, the pyrazolopyrimidine unit is slightly twisted. A combination of π-stacking and offset π-stacking interactions forms columns along the b-axis direction.
Mohamed El Hafi, Mohammed Boulhaoua, Youssef Ramli, Mohammed Benchidmi, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

High expression levels of pyrimidine metabolic rate–limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets

Purinergic Signalling Purinergic Signalling, 2020
Reprogramming of metabolism is described in many types of cancer and is associated with the clinical outcomes. However, the prognostic significance of pyrimidine metabolism signaling pathway in lung adenocarcinoma (LUAD) is unclear.
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang, Hua Cao   +4 more
semanticscholar   +1 more source

A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2018
Cytidine triphosphate synthase catalyzes the synthesis of cytidine 5′-triphosphate (CTP) from uridine 5′-triphosphate (UTP), the final step in the production of cytidine nucleotides.
Heidy Y. Narvaez-Ortiz, Andrea J. Lopez, Nishith Gupta, Barbara H. Zimmermann   +3 more
doaj   +1 more source

1,2,3-Triazolyl-tetrahydropyrimidine Conjugates as Potential Sterol Carrier Protein-2 Inhibitors: Larvicidal Activity against the Malaria Vector Anopheles arabiensis and In Silico Molecular Docking Study

Molecules, 2022
Alteration of insect growth regulators by the action of inhibitors is becoming an attractive strategy to combat disease-transmitting insects. In the present study, we investigated the larvicidal effect of 1,2,3-triazolyl-pyrimidinone derivatives against ...
Katharigatta N. Venugopala, Pottathil Shinu, Christophe Tratrat, Pran Kishore Deb, Raquel M. Gleiser, Sandeep Chandrashekharappa, Deepak Chopra, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Fawzi M. Mahomoodally, Michelyne Haroun, Mahmoud Kandeel, Syed Mohammed Basheeruddin Asdaq, Viresh Mohanlall, Nizar A. Al-Shar’i, Mohamed A. Morsy   +16 more
doaj   +1 more source

Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells

Science Translational Medicine, 2019
Concurrent targeting of pyrimidine synthesis and oncogenic driver pathways improves therapeutic efficacy in glioblastoma. Targeting metabolic changes in glioblastoma Glioblastoma (GBM) is the most aggressive brain cancer in adults.
Xiuxing Wang, Kailin Yang, Qiulian Wu, Leo J Y Kim, Andrew R. Morton, Ryan C. Gimple, B. Prager, Yu Shi, Wenchao Zhou, S. Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxin Zhang, Xiqing Li, S. Agnihotri, P. Mischel, S. Mack, S. Bao, J. Rich   +21 more
semanticscholar   +1 more source

Modulating pyrimidine ribonucleotide levels for the treatment of cancer

Cancer & Metabolism, 2020
By providing the necessary building blocks for nucleic acids and precursors for cell membrane synthesis, pyrimidine ribonucleotides are essential for cell growth and proliferation.
T. Mollick, S. Laín
semanticscholar   +1 more source