Results 31 to 40 of about 121,011 (315)

Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings

open access: yesFrontiers in Plant Science, 2023
In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum   +2 more
doaj   +1 more source

S=1/2 antiferromagnetic Heisenberg chain with staggered fields: Copper pyrimidine and copper benzoate using the density matrix renormalization group for transfer matrices [PDF]

open access: yesPhys. Rev. B 73, 220403(R) (2006), 2006
We consider the spin-1/2 antiferromagnetic Heisenberg chain in a staggered magnetic field describing materials such as copper benzoate and copper pyrimidine dinitrate. Using the density-matrix renormalization group for transfer matrices (TMRG) we calculate the magnetization of these materials at finite temperature and arbitrary magnetic field.
arxiv   +1 more source

Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis

open access: yesAngewandte Chemie International Edition, Volume 61, Issue 51, December 19, 2022., 2022
Hydrogen is a geological reducing agent that powers the metabolisms of modern organisms and potentially also powered the metabolism of the last universal common ancestor to all extant life. It is shown that catalytic amounts of transition metals or small amounts of powdered meteorites allow hydrogen to drive a key sequence of the reverse Krebs cycle ...
Sophia A. Rauscher, Joseph Moran
wiley   +1 more source

A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii

open access: yesFrontiers in Cellular and Infection Microbiology, 2018
Cytidine triphosphate synthase catalyzes the synthesis of cytidine 5′-triphosphate (CTP) from uridine 5′-triphosphate (UTP), the final step in the production of cytidine nucleotides.
Heidy Y. Narvaez-Ortiz   +3 more
doaj   +1 more source

Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and Evaluation of Their Antiviral Activity

open access: yesMolecules, 2022
A series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its (S)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of ...
Victor P. Krasnov   +9 more
doaj   +1 more source

Synthesis of Novel Tryptamine Derivatives and Their Biological Activity as Antitumor Agents

open access: yesMolecules, 2021
We synthesized five novel tryptamine derivatives characterized by the presence of an azelayl chain or of a 1,1,1-trichloroethyl group, in turn connected to another heterocyclic scaffold.
Giorgia Simonetti   +10 more
doaj   +1 more source

1-Methyl-3-(2-methylphenyl)-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine

open access: yesIUCrData, 2017
In the title compound, C19H16N4, the pyrazolopyrimidine unit is slightly twisted. A combination of π-stacking and offset π-stacking interactions forms columns along the b-axis direction.
Mohamed El Hafi   +5 more
doaj   +1 more source

3-(1-Cyclohexyl-2-(cyclohexylamino)-4-(4-ethoxyphenyl)-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methylquinoxalin-2(1H)-one

open access: yesMolbank, 2022
The reaction of 3-cyclohexyl-2-(cyclohexylimino)-6-(4-ethoxyphenyl)-5-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)-2,3-dihydro-4H-1,3-oxazin-4-one with ammonium acetate afforded 3-(1-cyclohexyl-2-(cyclohexylamino)-4-(4-ethoxyphenyl)-6-oxo-1,6 ...
Ekaterina E. Khramtsova   +3 more
doaj   +1 more source

Giant spin canting in the S = 1/2 antiferromagnetic chain [CuPM(NO3)2(H2O)2]n observed by 13C-NMR [PDF]

open access: yesPhys. Rev. Lett. 94, 057204 (2005), 2004
We present a combined experimental and theoretical study on copper pyrimidine dinitrate [CuPM(NO3)2(H2O)2]n, a one-dimensional S = 1/2 antiferromagnet with alternating local symmetry. From the local susceptibility measured by NMR at the three inequivalent carbon sites in the pyrimidine molecule we deduce a giant spin canting, i.e., an additional ...
arxiv   +1 more source

tert-Butyl 4-{3-[6-(4-methoxyphenyl)-2-methylpyrimidin-4-yl]quinolin-2-yl}piperazine-1-carboxylate

open access: yesIUCrData, 2018
The asymmetric unit of the title compound, C30H33N5O3, contains two independent molecules, A and B. In molecule A, the tert-butyl 4-methylpiperazine-1-carboxylate group was refined as disordered over two sets of sites with an occupancy ratio of 0.821 (4):
Sumati Anthal   +6 more
doaj   +1 more source

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