Results 51 to 60 of about 319,341 (367)

Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

PLoS Genetics, 2020
Glioblastoma is the most common and aggressive type of cancer in the brain; its poor prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent temozolomide, which is triggered by an increase in the expression of DNA repair
M. Lafita-Navarro, Niranjan Venkateswaran, Jessica A. Kilgore, S. Kanji, Jungsoo Han, Spencer D. Barnes, Noelle S. Williams, M. Buszczak, S. Burma, Maralice Conacci‐Sorrell   +9 more
semanticscholar   +1 more source

One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile

Molecules, 2020
A series of novel 7-substituted-5-(1H-indol-3-yl)tetrazolo[1,5-a]pyrimidine-6-carbonitrile was synthesized via a one-pot, three-multicomponent reaction of appropriate aldehydes, 1H-tetrazole-5-amine and 3-cyanoacetyl indole in catalytic triethylamine ...
Mohamed A. A. Radwan, Fahad M. Alminderej, Hanem M. Awad   +2 more
doaj   +1 more source

Synthesis of Some3-Chloro-2,3-dimethyl-1-phenylpyrazolidin-5-one [PDF]

Kirkuk Journal of Science, 2013
(E)-3-Chloro-4-arylidene-2,3-dimethyl-1-phenylpyrazolidin-5-one 1(a-c) which were used as synthon for synthesis of all target compounds were prepared from the reaction of 3-chloro-2,3-dimethyl-1-phenylpyrazolidin-5-one(Chlorophenazone)with aromatic ...
Moayed S.AL.Gawady, Shakir M. Saied, Moneera Y. Raoof   +2 more
doaj   +1 more source

Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings

Frontiers in Plant Science, 2023
In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum, Carolina Mejia Peña, Zhongchi Liu   +2 more
doaj   +1 more source

A Benchmark of GW Methods for Azabenzenes: Is the GW Approximation Good Enough?

, 2012
Many-body perturbation theory in the GW approximation is a useful method for describing electronic properties associated with charged excitations. A hierarchy of GW methods exists, starting from non-self-consistent G0W0, through partial self-consistency ...
Caruso, Fabio, Chelikowsky, James R., Hofmann, Oliver, Körzdörfer, Thomas, Marom, Noa, Ren, Xinguo, Rinke, Patrick, Rubio, Angel, Scheffler, Matthias   +8 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crystal structure of ethyl 5-(3-fluorophenyl)-2-[(4-fluorophenyl)methylidene]-7-methyl-3-oxo-2H,3H,5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Acta Crystallographica Section E, 2014
In the title molecule, C23H18F2N2O3S, the pyrimidine ring is in a half-chair conformation and the 3-fluorophenyl group is in the axial position. The thiazole ring (r.m.s.
M. S. Krishnamurthy, H. Nagarajaiah, Noor Shahina Begum   +2 more
doaj   +1 more source

Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors.
Mohammad M. Al-Sanea, Abdelrahman Hamdi, Simone Brogi, Samar S. Tawfik, Dina I. A. Othman, Mahmoud Elshal, Hidayat Ur Rahman, Della G. T. Parambi, Rehab M. Elbargisy, Samy Selim, Ehab M. Mostafa, Ahmed A. B. Mohamed   +11 more
doaj   +1 more source

Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking [PDF]

, 2010
The oxidative cyclisation of a range of benzothieno[2,3-d]pyrimidine hydrazones (7a–j) to the 1,2,4-triazolo[4,3-c]pyrimidines (8a–j) catalysed by lithium iodide or to the 1,2,4-triazolo[1,5-c]pyrimidines (10a–j) with sodium carbonate is presented.
Ahmed, Bhaskar, Brown, Chen, Curini, Dai, El Ashry, Feng, Gundla, Guy J. Clarkson, Han, Hassan, J. Michael Lord, Jennings, Joe, Khattab, Krueger, Kumar, Kumar, Lin, Lucie J. Guetzoyan, Lynne M. Roberts, Modena, Nagamatsu, Nagaraju, Phoujdar, Prakash, Prakash, Prakash, Prasad, Ram, Rashad, Rashad, Robert A. Spooner, Sadana, Shaban, Shaban, Sheldrick, Sheldrick, Shibahara, Shishoo, Spooner, Thakur, Tonnar, Vorob'ev, Wang, Yarrow   +46 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source