Results 61 to 70 of about 197,991 (343)

1-Methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine

IUCrData, 2017
In the crystal, molecules of the title compound, C12H10N4, stack in a head-to-tail manner along the b direction through π–π stacking interactions between both portions of the pyrazolopyrimidine ring system.
Mohamed El Hafi, Mohammed Boulhaoua, Abdelhanine Essaghouani, Youssef Ramli, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

Mevalonate pathway provides ubiquinone to maintain pyrimidine synthesis and survival in p53-deficient cancer cells exposed to metabolic stress.

Cancer Research, 2019
Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutrients
Irem Kaymak, C. R. Maier, W. Schmitz, A. Campbell, Beatrice Dankworth, C. Ade, S. Walz, M. Paauwe, C. Kalogirou, H. Marouf, M. Rosenfeldt, D. Gay, G. McGregor, O. Sansom, A. Schulze   +14 more
semanticscholar   +1 more source

A search for interstellar pyrimidine [PDF]

Monthly Notices of the Royal Astronomical Society, 2003
8 pages, 5 figures, accepted for publication in ...
H. C. Huang, Yi-Jehng Kuan, Yi-Jehng Kuan, Chi-Hung Yan, Zbigniew Kisiel, Pascale Ehrenfreund, Steven B. Charnley   +6 more
openaire   +3 more sources

Synthesis of Polycyclic Oxazolinium Compounds from Aryloxazolines and Alkynes via Dual Photoredox/Gold Catalysis and Rhodium Catalysis

Advanced Synthesis &Catalysis, EarlyView.
A series of polycyclic oxazolinium compounds is synthesized from various aryloxazolines with silyl‐substituted alkynes and internal alkynes via dual photoredox/gold catalysis and Rh‐catalyzed C–H bond functionalization, and affords silyl‐substituted polycyclic oxazoliniums and polycyclic oxazoliniums, respectively.
Lai‐Yi Tsang, Ajcharapan Tantipanjaporn, Karen Ka‐Yan Kung, Hoi‐Yi Sit, Wa‐Yi O, Aries Kwok‐Heung Chan, Nathanael Chun‐Him Lai, Man‐Kin Wong   +7 more
wiley   +1 more source

Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives

Molecules, 2006
2–Amino–4-phenyl–5,6,7,8–tetrahydroquinoline–3–carbonitrile (3) was synthesized by treating cyclohexanone (1) with 2–benzylidenemalononitrile (2) in the presence of ammonium acetate. The reactivity of compound 3 towards
Mohamed Abdelhamed Morsy, Yehya Mahmud Elkholy   +1 more
doaj   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism

Viruses, 2019
Viruses are parasites that depend on the host cell’s metabolic resources to provide the energy and molecular building blocks necessary for the production of viral progeny.
Irene Rodríguez-Sánchez, Joshua Munger
doaj   +1 more source

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Synthesis of various fused pyrimidine rings with their pharmacological and antimicrobial evaluation [PDF]

Journal of the Serbian Chemical Society, 2014
Various fused pyrimidine such as furo[2,3-d]pyrimidine, triazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine were synthesized from the reactions of thioxopyrimidine-6(1H)-ones with ethyl chloroacetate (under different reaction conditions ...
Mounir Salem A., Marzouk Magda I., Mahmoud Naglaa F.   +2 more
doaj   +1 more source

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Aging, 2019
The pyrimidine metabolism pathway has important biological functions; it not only maintains appropriate pyrimidine pools but also produces bioactive intermediate metabolites.
Qin-Li Wan, Xiao Meng, Xiaodie Fu, Bohui Chen, Jing Yang, Hengwen Yang, Qinghua Zhou   +6 more
semanticscholar   +1 more source