Results 91 to 100 of about 16,097 (238)

N-(2-{[5-Bromo-2-(piperidin-1-yl)pyrimidin-4-yl]sulfanyl}-4-methoxyphenyl)-4-methylbenzenesulfonamide

Acta Crystallographica Section E, 2012
In the title compound, C23H25BrN4O3S2, the benzene rings bridged by the sulfonamide group are tilted relative to each other by 69.7 (1)° and the dihedral angle between the sulfur-bridged pyrimidine and benzene rings is 70.4&#8197 ...
Mohan Kumar, L. Mallesha, M. A. Sridhar, Kamini Kapoor, Vivek K. Gupta, Rajni Kant   +5 more
doaj   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

Using Organic Synthesis and Chemical Analysis to Understand the Photochemistry of Spore Photoproduct and Other Pyrimidine Dimers

, 2017
Pyrimidine dimerization is the dominant DNA photoreaction occurring in vitro and in vivo. Three types of dimers, cyclobutane pyrimidine dimers (CPDs), pyrimidine (6-4) pyrimidone photoproducts (6-4PPs), and the spore photoproduct (SP), are formed from ...
Lei Li, Li, Lei
core   +1 more source

3-Benzoyl-5-chlorouracil

Acta Crystallographica Section E, 2009
The dihedral angle between the planes of two aromatic rings in the title compound [systematic name: 3-benzoyl-5-chloro-pyrimidine-2,4(1H,3H)-dione], C11H7ClN2O3, is 86.79 (6)°.
Keith Clinch, Graeme J. Gainsford
doaj   +1 more source

Oligomerization of Non‐Activated Nucleotides Under Hot Acidic Wet–Dry Cycling Without Catalytic Agents

ChemSystemsChem, Volume 8, Issue 4, July 2026.
Oligonucleotides form spontaneously through hot wet‐dry cycling of pure non‐activated nucleotides. No catalytic agents were added, and pH was naturally buffered by the nucleotides. Oligonucleotide formation was confirmed and quantified using mass spectrometry, spectroscopy and electrophoresis, establishing a solid baseline for the intrinsic extent of ...
Simon H. J. Eiby, Morten J. Bjerrum, Bálint Hajdu, Laura Da Silva, Peter W. Thulstrup, Tue Hassenkam   +5 more
wiley   +1 more source

Dynamic accumulation of cyclobutane pyrimidine dimers and its response to changes in DNA conformation. [PDF]

Nucleic Acids Res, 2023
Moirangthem R, Gamage MN, Rokita SE.
europepmc   +1 more source

Assessment of Ocular Surface Pathogen Susceptibility to Ultraviolet‐C (UVC) Light Treatment With a Novel Prototype Device—An In Vitro Study

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Purpose Assess in vitro efficacy of a device emitting 265 nm UVC light against bacteria isolated from veterinary infectious keratitis. Methods Twenty‐seven clinically‐derived bacterial isolates: Staphylococcus pseudintermedius (n = 10; including n = 2 methicillin‐resistant Staphylococcus pseudintermedius [MRSP]), Staphylococcus aureus (n = 1),
Oliver Joe Williams, Charlotte Dawson, Maria‐Christine Fischer, Siân‐Marie Frosini   +3 more
wiley   +1 more source

Production of Pyrimidine Dimers in DNA of Human Skin Exposed In Situ to UVA Radiation

, 1987
Cyclobutyl pyrimidine dimers, measured as sites recognized by the dimer-specific ultraviolet (UV) endonuclease from Micrococcus luteus, were produced in DNA of human skin exposed in situ to UVA (320-400 nm) radiation.
Gange, Richard W., Sutherland, Betsy M., Freeman, Steven E., Matzinger, Ezra A., Sutherland, John C.   +4 more
core   +1 more source

5-Bromo-2-chloropyrimidin-4-amine

Acta Crystallographica Section E, 2013
In the title compound, C4H3BrClN3, the pyrimidine ring is essentially planar (r.m.s. deviation from the plane = 0.087 Å). In the crystal, pairs of N—H...N hydrogen bonds connect the molecules into inversion dimers; these are connected by
Mohan Kumar, C. Mallikarjunaswamy, M. A. Sridhar, D. G. Bhadregowda, Kamini Kapoor, Vivek K. Gupta, Rajni Kant   +6 more
doaj   +1 more source

The Role of Acetyl Zingerone and Its Derivatives in Inhibiting UV-Induced, Incident, and Delayed Cyclobutane Pyrimidine Dimers. [PDF]

Antioxidants (Basel), 2023
Srivastava J, Young MM, Yadav VK, Phadatare PR, Meyer TA, Chaudhuri RK, Premi S.   +6 more
europepmc   +1 more source