Results 101 to 110 of about 16,097 (238)
The Molecular Perspective: Ultraviolet Light and Pyrimidine Dimers [PDF]
STEM CELLS, 2001 we go about our daily activities. Whenever we walk in the sun, ultraviolet light (UV) attacks our DNA, making chemical changes that corrupt our genetic information. Fortunately, the most dangerous UV light never reaches us at all: the ozone in the upper atmosphere absorbs (at least for now) the energetic UVC wavelengths.
openaire +3 more sources
ChemElectroChem, Volume 13, Issue 12, 17 June 2026.Redox‐active guanidines, comprising guanidino‐functionalized aromatics (GFAs) and redox‐active urea azines (RAAs), are electron donors and strong Lewis and Brønsted bases that are used in several applications. They act as redox‐active ligands in bistable coordination compounds and as reagents in dehydrogenative coupling reactions and proton‐coupled ...
Hans‐Jörg Himmel
wiley +1 more source
N-(2-Chloropyrimidin-4-yl)-N,2-dimethyl-2H-indazol-6-amine
Acta Crystallographica Section E, 2010 In the title compound, C13H12ClN5, which is a derivative of the antitumor agent pazopanib {systematic name: 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzolsulfonamide}, the indazole and pyrimidine fragments form a ...
Hao-Fei Qi +3 more
doaj +1 more source
DNA Containing Cyclobutane Pyrimidine Dimers Is Released from UVB-Irradiated Keratinocytes in a Caspase-Dependent Manner. [PDF]
J Invest Dermatol, 2022 Carpenter MA, Ginugu M, Khan S, Kemp MG.
europepmc +1 more source
Affinity Enhancement in Discrete Multivalent MegaMolecules
ChemBioChem, Volume 27, Issue 11, 15 June 2026.We design discrete protein megamolecules with precisely controlled valency (1–6 nanobodies), which exhibit strong avidity‐driven affinity enhancement toward epidermal growth factor receptor and human epidermal growth factor receptor. We systematically investigate the roles of valency, intrinsic affinity, and spatial presentation in optimizing binding ...
Zhaoyi Gu +7 more
wiley +1 more source
, 1993 The effect of hyperthermia on induction and repair of UV-radiation-induced cyclobutane pyrimidine dimers was investigated in the genome overall and in transcriptionally active and inactive genes in confluent human fibroblasts.
Brunsting, J F +6 more
core +1 more source
2-[4-(Piperidin-1-yl)-5H-chromeno[2,3-d]pyrimidin-2-yl]phenol
Acta Crystallographica Section E, 2014 In the title compound, C22H21N3O2, the pyrimidine ring is essentially planar [maximum deviation = 0.018 (2) Å] and forms dihedral angles of 22.70 (8) and 0.97 (7)°, respectively, with the fused benzene ring and the hydroxy-substituted benzene ring.
Naresh Sharma +4 more
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Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou +10 more
wiley +1 more source
Comparative Removal of Pyrimidine Dimers from Human Epidermal Keratinocytes In Vivo and In Vitro
, 1988 We have compared the kinetics for repair of UV-induced cyclobutane pyrimidine dimers in the DNA of keratinocytes in human skin and in cell culture. A small area of the buttocks of volunteers was exposed to UVB-irradiation and biopsies were taken at ...
Reusch, Michael K. +3 more
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N-(2-Bromo-4-methylphenyl)-2-(5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl)acetamide
Acta Crystallographica Section E, 2013 The fused pyrazole and pyrimidine rings in the title compound, C22H19BrN4O, are almost coplanar, their planes being inclined to one another by 2.08 (13)°. The dihedral angles formed by the mean plane of the fused ring system and the phenyl and
Ibtissam Bassoude +4 more
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