Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors [PDF]
Microorganisms, 2022 Tuberculosis (TB) is the oldest human infection disease. Mortality from TB significantly decreased in the 20th century, because of vaccination and the widespread use of antibiotics.
Liudmila A. Alexandrova +4 more
doaj +2 more sources
Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice [PDF]
Nature Communications, 2023 Concentrative nucleoside transporters (CNTs) are active nucleoside influx systems, but their in vivo roles are poorly defined. By generating CNT1 knockout (KO) mice, here we identify a role of CNT1 in the renal reabsorption of nucleosides.
Avinash K. Persaud +22 more
doaj +2 more sources
Biocoordination reactions in copper(II) ions and phosphocholine systems including pyrimidine nucleosides and nucleotides [PDF]
Scientific Reports, 2023 The complexation reactions of phosphocholine and pyrimidine nucleosides as well as nucleotides with copper(II) ions were studied in the water system.
Malwina Gabryel-Skrodzka +3 more
doaj +2 more sources
Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides [PDF]
Molecules, 2020 Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose)polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. New effective Tdp1 inhibitors were found in a series of nucleoside derivatives
Alexandra L. Zakharenko +8 more
doaj +2 more sources
Tracking excited state decay mechanisms of pyrimidine nucleosides in real time [PDF]
Nature Communications, 2021 The photophysical mechanism by which nucleosides dissipate energy after UV light irradiation is still under debate. Here the authors, using ultrafast time resolved optical spectroscopies and quantum chemical computations, resolve the early steps of such ...
Rocío Borrego-Varillas +12 more
doaj +2 more sources
Response of Escherichia coli chemotaxis pathway to pyrimidine deoxyribonucleosides [PDF]
Microbiology SpectrumNucleosides are essential components of all living cells. Bacteria use salvage pathways to import nucleosides from their environment and to utilize them for nucleic acid biosynthesis, but also as alternative sources of carbon, nitrogen and energy. Motile
Malay Shah, Wenhao Xu, Victor Sourjik
doaj +2 more sources
A Straightforward Diphenylmethyl Protection Method and Deprotection of Some Pyrimidine Nucleosides [PDF]
Molecules, 2013 Benzhydryl protection of primary and secondary alcohols has been reported previously via reaction with metal alcoholates. Our aim was to find generally useful and very mild conditions for the alcoholic protection and deprotection of nucleosides with the ...
Arthur van Aerschot, Milind Saudi
doaj +2 more sources
Pyrimidine nucleoside: inspiration for novel antimicrobial agent [PDF]
Frontiers in PharmacologyAntimicrobial resistance (AMR) is a worsening global health crisis, with drug repurposing emerging as a key mitigation strategy. Pyrimidine nucleosides are promising antibacterial scaffolds due to their easily modifiable structures and multi-therapeutic ...
Binjie Xu +4 more
doaj +2 more sources
Derivatives of Pyrimidine Nucleosides Affect Artificial Membranes Enriched with Mycobacterial Lipids [PDF]
PharmaceuticsThe mechanisms of action of pyrimidine nucleoside derivatives on model lipid membranes of various compositions were studied. A systematic analysis of the tested agents’ effects on the membrane physicochemical properties was performed.
Olga S. Ostroumova +8 more
doaj +2 more sources
Modification of Purine and Pyrimidine Nucleosides by Direct C-H Bond Activation [PDF]
Molecules, 2015 Transition metal-catalyzed modifications of the activated heterocyclic bases of nucleosides as well as DNA or RNA fragments employing traditional cross-coupling methods have been well-established in nucleic acid chemistry.
Yong Liang, Stanislaw F. Wnuk
doaj +2 more sources