Results 41 to 50 of about 22,404 (220)
A Unifying Concept for the Prebiotic Formation of RNA Pyrimidine Nucleosides
ChemistryEurope, 2023 The question of how nucleosides might have formed as essential precursor molecules on the early Earth is one of the many challenges associated with the origin of life.
Jonas Feldmann +5 more
doaj +1 more source
(β-D-ribofuranosyl)formamidine in the design and synthesis of 2-(β-D-ribofuranosyl)pyrimidines, including RF-containing derivatives [PDF]
, 2013 A wide range of novel 2-(β-D-ribofuranosyl)pyrimidines, including RF-containing derivatives, have been synthesized by the reaction of (β-D-ribofuranosyl)formamidine with various dielectrophilic substrates such as 3-alkoxy- and 3-chloro-1-(polyfluoroalkyl)
Adlington +48 more
core +1 more source
Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair
The Journal of Clinical Investigation, 2022 Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair.
Shen Li +31 more
doaj +1 more source
iScience, 2022 Summary: The nucleoside analog N4-hydroxycytidine (NHC) is the active metabolite of the prodrug molnupiravir, which has been approved for the treatment of COVID-19. SARS-CoV-2 incorporates NHC into its RNA, resulting in defective virus genomes. Likewise,
Kim M. Stegmann +24 more
doaj +1 more source
Molecules, 2022 Pyrimidine nucleoside analogues are widely used to treat infections caused by the human immunodeficiency virus (HIV) and DNA viruses from the herpes family. It has been shown that 5-substituted uracil derivatives can inhibit HIV-1, herpes family viruses,
Vasily A. Kezin +7 more
doaj +1 more source
Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]
, 2016 Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P. +4 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini +19 more
wiley +1 more source
Preparation of Pyrimidine Alkenyl Acyclic Nucleoside Phosphonoamidates [PDF]
Current Protocols in Nucleic Acid Chemistry, 2018 AbstractThis synthetic protocol describes two strategies for the preparation of pyrimidine alkenyl acyclic nucleoside phosphonoamidates (ANPs), including linear and trisubstituted alkenyl derivatives. For the first procedure, a bis‐trimethylsilyl ester of the parent alkenyl ANPs is the key intermediate that reacts with the desired amino acid ester and ...
Pileggi, Elisa +2 more
openaire +2 more sources
An Aminoisoxazole‐Based Proto‐RNA
ChemistryEurope, 2023 The RNA world hypothesis predicts that life started with the development of replicating and catalytically active RNA, which evolved in a process of molecular evolution to increasingly complex chemical structures.
Felix Xu +4 more
doaj +1 more source
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources