Results 51 to 60 of about 22,404 (220)

Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris

Biological Diversity, EarlyView.
Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu, Jia Li, Xin Liu, Xue‐Jun Ge, Hui‐Run Huang   +4 more
wiley   +1 more source

Stereospecific synthesis of  -anomeric pyrimidine nucleoside [PDF]

Nucleic Acids Symposium Series, 2000
A facile stereospecific synthetic method for alpha-anomeric 2'-deoxypyrimidine nucleoside unit utilizing aminooxazoline derivative of ribofuranose was investigated. Thus, easily accessible riboaminooxazoline derivative prepared by ribose and cyanamid was allowed to react with ethyl alpha-bromoethylacrylate to give corresponding adduct.
K, Shinozuka, N, Matsumoto, A, Nakamura, H, Hayashi, H, Sawai   +4 more
openaire   +2 more sources

Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann, Constanze C. Schmies, Georg Wilhelm Rolshoven, Mirko Scortichini, Stefan Wagner, Andreas Isaak, Riham M. Idris, Jennifer Dabel, Lucie Grey, Karolina Losenkova, Susanne Moschütz, Haneen Al Hroub, Antje Keim, Sandra Höppner, Jouko Sandholm, Pia Boström, Maija Hollmén, Norbert Sträter, Sven Hermann, Gennady G. Yegutkin, Kenneth A. Jacobson, Sonja Schelhaas, Christa E. Müller, Anna Junker   +23 more
wiley   +2 more sources

Determination of total potentially available nucleosides in bovine milk [PDF]

, 2010
Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D., Indyk, Harvey E., Manley-Harris, Merilyn   +2 more
core   +2 more sources

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Investigation of 8-Aza-7-Deaza Purine Nucleoside Derivatives

Molecules, 2019
Glycosylation of 6-amino-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine and its iodo- and bromo- analogues with the protected ribofuranose and 2′-deoxyribofuranose under different conditions resulted in the synthesis of N9- and N8-glycosylated purine ...
Hang Ren, Haoyun An, Jingchao Tao
doaj   +1 more source

Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms [PDF]

, 2013
<p>Background: African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.</p> <p>Methodology/Principal ...
A Hofer, Anne Donachie, B Aronow, B Rodenko, BA Fox, Ben L. Kelly, CC Wang, D Bi, Daniel N. A. Tagoe, DB Longley, DJ Hammond, ET Larson, G Gao, G Priotto, H Hirumi, Harry P. de Koning, HF Hassan, HMS Ibrahim, HP De Koning, HP De Koning, HP De Koning, HP De Koning, HP De Koning, HP De Koning, IG Papageorgiou, JA Ali, Jane C. Munday, JB French, Juma A. M. Ali, K Van Dyke, KL Martin, Liam J. Morrison, LJ Wallace, M Balasegaram, M Berg, M Berg, MD Scahill, MI Al-Salabi, MJ Natto, MK Gould, N Sienkiewicz, N Sternberg, PI Fields, R Brun, R Brun, S Gudin, S Lillico, SM Landfear, TL Arakaki, V Bellofatto, VM Castillo-Acosta, ZN Wilson   +51 more
core   +4 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Metabolism of Pyrimidines and Pyrimidine Nucleosides by Salmonella typhimurium [PDF]

Journal of Bacteriology, 1972
The pathways by which uracil, cytosine, uridine, cytidine, deoxyuridine, and deoxycytidine are metabolized by Salmonella typhimurium are established. The various 5-fluoropyrimidine analogues are shown to exert their toxic effects only after having been converted to the nucleotide level, and these conversions are ...
C F, Beck, J L, Ingraham, J, Neuhard, E, Thomassen   +3 more
openaire   +2 more sources

Infrared Spectroscopy of RNA Nucleosides in a Wide Range of Temperatures

Life
The RNA world hypothesis suggests that early cellular ancestors relied solely on RNA molecules for both genetic information storage and cellular functions.
Susana Iglesias-Groth, Franco Cataldo, Martina Marin-Dobrincic   +2 more
doaj   +1 more source