Results 11 to 20 of about 11,329 (154)

Chiral hypervalent iodine catalyzed stereoselective skeletal editing of pyrimidine fused heterocycles [PDF]

Nature Communications
In the realm of molecular construction, the skeletal editing techniques of heterocyclic compounds demonstrate unique efficiency, particularly in synthesizing molecular structures that are challenging to obtain through traditional synthetic methods ...
Wen-Wu Sun, Yi-Bing Xie, Bin Wu
doaj   +2 more sources

Landscape of targets within nucleoside metabolism for the modification of immune responses [PDF]

Frontiers in Oncology
Nucleoside metabolism regulates immune cell development and function, but the therapeutic implications of this link have yet to be fully realized. Evidence for the importance of nucleoside metabolism in immune system control was provided by observations ...
Ella M. Dunderdale, Evan R. Abt
doaj   +2 more sources

Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism.

PLoS ONE, 2023
Tetrahymena are ciliated protists that have been used to study the effects of toxic chemicals, including anticancer drugs. In this study, we tested the inhibitory effects of six pyrimidine analogs (5-fluorouracil, floxuridine, 5'-deoxy-5-fluorouridine, 5-
Zander Harpel, Wei-Jen Chang, Jacob Circelli, Richard Chen, Ian Chang, Jason Rivera, Stephanie Wu, RongHan Wei   +7 more
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Conical intersection dynamics of pyrimidine nucleosides tracked with sub-20-fs UV pulses [PDF]

EPJ Web of Conferences, 2019
By combining transient absorption spectroscopy with sub-20-fs UV pulses and ab initio numerical simulations we follow the ultrafast dynamics in pyrimidine nucleosides and visualize the passage through conical intersections presiding excited state ...
Borrego-Varillas Rocío, Nenov Artur, Ganzer Lucia, Oriana Aurelio, Conti Irene, Delfino Ines, Manzoni Cristian, Garavelli Marco, Cerullo Giulio   +8 more
doaj   +1 more source

Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy

Cells, 2022
Nucleotides are synthesized through two distinct pathways: de novo synthesis and nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino acids and glucose, the salvage pathway recovers nucleosides or bases formed during DNA or ...
Melanie Walter, Patrick Herr
doaj   +1 more source

An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)

Molecules, 2013
An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine ...
Roger Stromberg, Jyotirmoy Maity
doaj   +1 more source

Synthesis and Biological Activity of Reversed Pyrimidine Nucleosides

Croatica Chemica Acta, 2015
An efficient approach to reversed nucleosides which enables their synthesis in gram quantities is described. N-1′-Pyrimidine reversed nucleosides were prepared by treating of the sodium salt of pyrimidine bases with protected 5-tosyl ribose ...
Nataša Župančić, Željka Ban, Josipa Matić, Dijana Saftić, Ljubica Glavaš-Obrovac, Biserka Žinić   +5 more
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Selective Formation of Intramolecular Hydrogen-Bonding Palladium(II) Complexes with Nucleosides Using Unsymmetrical Tridentate Ligands

Molecules, 2022
Three palladium(II) complexes with amino-amidato-phenolato-type tridentate ligands were synthesized and characterized by 1H NMR spectroscopy and X-ray crystallography.
Ryoji Mitsuhashi, Yuya Imai, Takayoshi Suzuki, Yoshihito Hayashi   +3 more
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2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions

Nature Communications, 2021
UV-induced photodamage that likely occurred during the prebiotic synthesis of DNA and RNA is still an untackled issue for their origin on early Earth. Here, the authors show that substitution of 2,6-diaminopurine for adenine enables repair of cyclobutane
Rafał Szabla, Magdalena Zdrowowicz, Paulina Spisz, Nicholas J. Green, Petr Stadlbauer, Holger Kruse, Jiří Šponer, Janusz Rak   +7 more
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Wavelength dependent excited state dynamics observed in canonical pyrimidine nucleosides

Journal of Photochemistry and Photobiology, 2023
Epidemiological evidence indicates that damage to DNA/RNA initialized by ultraviolet (UV) radiation is associated with skin cancer. Wavelength dependence of DNA photodamage was proposed as early as 1990s and demonstrated later on.
Peicong Wu, Xueli Wang, Haifeng Pan, Jinquan Chen   +3 more
doaj   +1 more source