Results 151 to 160 of about 68,807 (327)
Flowering in Fruit Trees and Annual Plants as Affected by Purines, Pyrimidines and Triiodobenzoic Acid. [PDF]
, 1959 B. Kessler, RPM Bak, A. Cohen
openalex +1 more source
ChemMedChem, EarlyView.Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar +10 more
wiley +1 more source
Crystal structure of Methanococcus jannaschii dihydroorotase
Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 1, Page 91-98, January 2023., 2023 Abstract In this paper, we report the structural analysis of dihydroorotase (DHOase) from the hyperthermophilic and barophilic archaeon Methanococcus jannaschii. DHOase catalyzes the reversible cyclization of N‐carbamoyl‐l‐aspartate to l‐dihydroorotate in the third step of de novo pyrimidine biosynthesis.
Jacqueline Vitali +3 more
wiley +1 more source
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites
ChemMedChem, EarlyView.Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert +6 more
wiley +1 more source
Studies in Vitro of Digestion and Absorption of Pyrimidine Nucleotides by the Intestine
, 1958 Tony Wilson, Darrell M. Wilson
openalex +1 more source
Isolation and Separation of the Pyrimidine Nucleosides of Yeast Ribosenucleic Acid [PDF]
, 1948 R. J. C. Harris, J. F. Thomas
openalex +1 more source
Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates
ChemMedChem, EarlyView.Antibody‐drug conjugates (ADCs) have emerged as a powerful form of targeted therapeutic. However, despite the myriad methods to generate even‐integer drug‐to‐antibody ratio (DAR) ADCs, strategies to generate DAR 1 are seldom reported despite the property tuning advantages of low drug loading or in enabling access to antibody‐protein constructs.
Thomas Wharton, David R. Spring
wiley +1 more source
Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy
ChemPlusChem, Accepted Article.The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber +3 more
wiley +1 more source