Results 221 to 230 of about 72,841 (281)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Deuteration of Six-Membered N-Heteroarenes: Chemistry and Applications. [PDF]

Chemistry
Raju L, Tiz DB, Iles A, Košmrlj J, Jansen-van Vuuren RD.   +4 more
europepmc   +1 more source

Bioisosteric replacement in the search for antimicrobial agents: design, synthesis and activity of novel 6-(1h-Benzimidazol-2-yl)-1-alkyl-3,5-dimethylthieno[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives

Olena Vlasova, Sergiy V. Vlasov, Hanna Severina, Oleksandr V. Borysov, Georgiy G. Yakovenko, Andrii Khairulin, Pavlo E. Shynkarenko, Roman Rudenko, Vladimir Bozhanov, Nataliia Smielova, Н. І. Філімонова, Victoriya Georgiyants   +11 more
openalex   +2 more sources

NMR‐Based Structural Analysis of Highly Substituted Pyridines From Kondrat'eva Aza‐Diels–Alder Cycloadditions

Magnetic Resonance in Chemistry, Volume 64, Issue 3, Page 324-332, March 2026.
We report the results from a kinetic and mechanistic investigation of an inverse‐electron‐demand Diels–Alder (IEDDA) cycloaddition involving an oxazole‐type diene synthesized via an Ugi–Zhu multicomponent reaction (UZ‐3CR). ABSTRACT Pyridines are a crucial class of heterocycles with widespread applications in natural products, pharmaceuticals, and ...
Galdina V. Suárez‐Moreno, Francisco Méndez, Atilano Gutierrez‐Carrillo, Mónica A. Rincón‐Guevara, Yoarhy A. Amador‐Sánchez, Alejandro Islas‐Jácome, Eduardo González‐Zamora   +6 more
wiley   +1 more source

Scaffold-Hopping Design and Synthesis of Thieno[3,2-<i>d</i>]pyrimidines: Anticancer Activity, Apoptosis Induction, and In Silico Inhibition of CDKs. [PDF]

Int J Mol Sci
Ruzi Z, Buronov A, Nie L, Nasrullaev A, Murtazaeva Z, Kuryazov R, Zhao J, Efferth T, Aisa HA, Bozorov K.   +9 more
europepmc   +1 more source

Purine and pyrimidine metabolism in lymphoid cells of man and some other mammalian species

, 1982
Godefridus J. Peters
openalex   +1 more source

Insights Into Gut Barrier Dysfunction and Metabolic Alterations in Mycophenolate‐Induced Enteropathy

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Mycophenolic acid (MPA) is a widely used immunosuppressant whose use is often limited by gastrointestinal toxicity. Gut bacterial hydrolysis of liver‐derived MPA glucuronides increases local exposure to MPA, potentially impairing epithelial barrier function and cellular metabolism.
Clarisse Brossier, François‐Ludovic Sauvage, Christel Valencia‐Schmitt, Valérie Calco, Pascal Villa, Pierre Marquet, Roland Lawson   +6 more
wiley   +1 more source

Fe₃O₄@SiO₂-SnCl₄-promoted synthesis, cytotoxic evaluation, molecular docking, and MD simulation of some indenopyrido[2,3-d]pyrimidine derivatives. [PDF]

BMC Chem
Emami L, Baziyar L, Al-Dies AM, Sadeghian S, Mirjalili BBF, Faghih Z, Khorasani S, Zamani L, Khabnadideh S.   +8 more
europepmc   +1 more source

Synthesis of novel spiro[chromeno[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines via an isatin-based three-component reaction. [PDF]

Sci Rep
Khalili M, Esmaeili AA.
europepmc   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source