Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
Pharmaceuticals, 2022 A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in
Iván Díaz +3 more
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Dipole oscillator strength distributions, sum rules, mean excitation energies, and isotropic van der Waals coefficients for benzene, pyridazine, pyrimidine, pyrazine, s-triazine, toluene, hexafluorobenzene, and nitrobenzene [PDF]
J. Chem. Phys. 153, 124307 (2020), 2020 Experimental, theoretical, and additive-model photoabsorption cross-sections combined with constraints provided by the Kuhn-Reiche-Thomas sum rule and the high-energy behavior of the dipole-oscillator-strength density are used to construct dipole oscillator strength distributions for benzene, pyridazine (1,2-diazine), pyrimidine (1,3-diazine), pyrazine
arxiv +1 more source
Synthesis of New Pyrazole and Pyrimidine Steroidal Derivatives
Molecules, 2003 The synthesis of steroidal heterocycles containing the pyrazole and pyrimidine ring fused to the 16,17-position of the steroid nucleus is reported. Androstenolone acetate (1) reacted with carbon disulfide, iodomethane and sodium hydride to furnish 3β ...
Francisco Coll +5 more
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S=1/2 antiferromagnetic Heisenberg chain with staggered fields: Copper pyrimidine and copper benzoate using the density matrix renormalization group for transfer matrices [PDF]
Phys. Rev. B 73, 220403(R) (2006), 2006 We consider the spin-1/2 antiferromagnetic Heisenberg chain in a staggered magnetic field describing materials such as copper benzoate and copper pyrimidine dinitrate. Using the density-matrix renormalization group for transfer matrices (TMRG) we calculate the magnetization of these materials at finite temperature and arbitrary magnetic field.
arxiv +1 more source
Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis
Angewandte Chemie International Edition, Volume 61, Issue 51, December 19, 2022., 2022 Hydrogen is a geological reducing agent that powers the metabolisms of modern organisms and potentially also powered the metabolism of the last universal common ancestor to all extant life. It is shown that catalytic amounts of transition metals or small amounts of powdered meteorites allow hydrogen to drive a key sequence of the reverse Krebs cycle ...
Sophia A. Rauscher, Joseph Moran
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2019 The LANCA three-component reaction of lithiated alkoxyallenes LA, nitriles N and carboxylic acids CA leads to β-ketoenamides KE in good to excellent yields.
Tilman Lechel +4 more
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Carbazole- and Triphenylamine-Substituted Pyrimidines: Synthesis and Photophysical Properties
Molecules, 2019 A series of pyrimidine derivatives bearing one, two or three triphenylamine/9-ethylcarbazole substituents has been synthesized by Suzuki cross-coupling reaction. All compounds showed absorption bands in the UV region and the emission of violet-blue light
Sylvain Achelle +4 more
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Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives [PDF]
Journal of the Serbian Chemical Society, 2007 The synthesis of thiazolo [5,4-d]pyrimidines can be achieved from different 5-thiazolidinones, 2-butyl-1H-imidazole-5-carbaldehyde and thiourea using microwave irradiation within 5 min.
S. J. VAGHASIA, V. H. SHAH
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Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C10H16N2O9S3, the pyrimidine ring of the 1,3-dimethyl barbituric acid moiety has an envelope conformation with the C atom carrying the methylsulfonyl and bis(methylsulfonyl)methyl substituents as the flap.
Eyad Mallah +4 more
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Design, Synthesis, and Biological Evaluation of PKD Inhibitors
Pharmaceutics, 2011 Protein kinase D (PKD) belongs to a family of serine/threonine kinases that play an important role in basic cellular processes and are implicated in the pathogenesis of several diseases.
Marie-Céline Frantz +9 more
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