Results 41 to 50 of about 35,554 (229)
Anti-Mycobacterial Activity of Flavonoid and Pyrimidine Compounds
Molecules, 2022 We evaluated the anti-mycobacterial effect of a flavonoid 5,7-dihydroxy-2-(4-hydroxyphenyl) 4H-chromen-4-one (1) and two pyrimidines, 4-hydroxy-2-dimethylamino-5-nitroso-6-aminopyrimidine (2) and 2-chloro-5-n-nonylpyrimidine (3) in vitro against ...
Saurabh Garg +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions
Angewandte Chemie, EarlyView.This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan +3 more
wiley +2 more sources
Molecules, 2022 Positive allosteric modulators (PAMs) of AMPA receptors represent attractive candidates for the development of drugs for the treatment of cognitive and neurodegenerative disorders.
Kseniya N. Sedenkova +10 more
doaj +1 more source
Synthesis and Biological Evaluation of New Chromenes and Chromeno[2,3-d] pyrimidines [PDF]
, 2021 Fatima Belhadj +6 more
openalex +1 more source
Advanced Functional Materials, EarlyView.Fe─NC porous oxygen reduction electrocatalysts are prepared employing a 2,4,6‐Triaminopyrimidine‐based porous organic polymer, a Mg2+ Lewis acid, and a low‐temperature cation exchange protocol. Using the polymer precursor achieves high pyrolysis yields and results in atomically dispersed FeNx sites. The resulting catalysts feature hierarchical porosity
Eliot Petitdemange +11 more
wiley +1 more source
Photothermal Conversion Promotes Challenging SNAr for Facile C─N Bond Formation
Angewandte Chemie, EarlyView.Photothermal conversion enables facile aromatic C─N bond formation via red light irradiation. A variety of inter‐ and intramolecular SNAr transformations are achieved under mild, schematically simple conditions. Additionally, a thermally promoted halogen exchange mechanism provides access to aryl bromides, chlorides, and fluorides – making this ...
Megan E. Matter +2 more
wiley +2 more sources
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021 The relevance of the study of 1,2,4-triazole derivatives with pyrimidine fragment is due to the synthesis of potential broad-spectrum antibacterial drugs, low molecular weight inducers of interferon, and antitumor agents, search for molecular descriptors
Yu. V. Karpenko, O. I. Panasenko
doaj +1 more source
Advanced Functional Materials, EarlyView.DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen +3 more
wiley +1 more source
18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings
Angewandte Chemie, EarlyView.A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy +13 more
wiley +2 more sources