Results 41 to 50 of about 68,807 (327)
Preparation and Characterization of Derivatives of Pyrimidines in two ways Clascical and Microwave [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2017 This study includes synthesis and characterization of new pyrimidine derivatives (R or Ar-2,3,4,6,7,8-hexahydroquinazolin-5(1H)-one), via of the reaction from cyclohexane-1,3-dione with aldehyde derivatives and guanidinehydrochlorid.
Waleed AL-Hiti +2 more
doaj +1 more source
Giant spin canting in the S = 1/2 antiferromagnetic chain [CuPM(NO3)2(H2O)2]n observed by 13C-NMR [PDF]
Phys. Rev. Lett. 94, 057204 (2005), 2004 We present a combined experimental and theoretical study on copper pyrimidine dinitrate [CuPM(NO3)2(H2O)2]n, a one-dimensional S = 1/2 antiferromagnet with alternating local symmetry. From the local susceptibility measured by NMR at the three inequivalent carbon sites in the pyrimidine molecule we deduce a giant spin canting, i.e., an additional ...
arxiv +1 more source
Electronic structure of the molecule based magnet Cu PM(NO3)2 (H2O)2 [PDF]
Phys. Rev. B 75, 184433 (2007), 2007 We present density functional calculations on the molecule based S=1/2 antiferromagnetic chain compound Cu PM(NO3)2 (H2O)2; PM = pyrimidine. The properties of the ferro- and antiferromagnetic state are investigated at the level of the local density approximation and with the hybrid functional B3LYP.
arxiv +1 more source
Metabolism of Pyrimidines and Pyrimidine Nucleosides by Salmonella typhimurium [PDF]
Journal of Bacteriology, 1972 The pathways by which uracil, cytosine, uridine, cytidine, deoxyuridine, and deoxycytidine are metabolized by Salmonella typhimurium are established. The various 5-fluoropyrimidine analogues are shown to exert their toxic effects only after having been converted to the nucleotide level, and these conversions are ...
Elisabeth Thomassen +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
Weak ferromagnetism with very large canting in a chiral lattice: (pyrimidine)2FeCl2 [PDF]
, 2003 The transition metal coordination compound (pyrimidine)2FeCl2 crystallizes in a chiral lattice, space group I 4_1 2 2 (or I4_3 2 2). Combined magnetization, Mossbauer spectroscopy and powder neutron diffraction studies reveal that it is a canted antiferromagnet below T_N = 6.4 K with an unusually large canting of the magnetic moments of 14 deg.
arxiv +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Exosomes and their roles in the chemoresistance of pancreatic cancer
Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022 Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan +4 more
wiley +1 more source
Molecules, 2013 Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active ...
Eman A. El-Bordany +2 more
doaj +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source