Results 41 to 50 of about 172,292 (284)

Synthesis and polymerization of 1-(2-diallylaminoethyl)pyrimidines

Designed Monomers and Polymers, 2018
We report the preparation and characterization of three pyrimidine-based monomers, specifically: 1-(2-diallylaminoethyl)uracil, 1-(2-diallylaminoethyl)thymine and 1-(2-diallylaminoethyl)cytosine.
Jomana Elaridi, Alaa Ezzeddine, Lara Abramian, Ali Koubeissi, Nikolay Vladimirov, Kamal H. Bouhadir   +5 more
doaj   +1 more source

Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.

Journal of Medicinal Chemistry, 2018
We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines as tubulin polymerization inhibitors targeting the colchicine binding site with significantly improved therapeutic index.
Souvik Banerjee, K. Arnst, Yuxi Wang, G. Kumar, Shanshan Deng, Lei Yang, Guo-Bo Li, Jinliang Yang, S. White, Wei Li, Duane D. Miller   +10 more
semanticscholar   +1 more source

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death [PDF]

, 2010
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication.
A Gartland, A Hoebertz, A Surprenant, A Trautmann, A Verkhratsky, AN Drury, AV Gourine, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, B Hechler, B Johansson, B Vandewalle, BB Fredholm, BB Fredholm, BS Khakh, BS Khakh, C Giaume, C Ledent, C Ponnamperuma, CA Salvatore, CH Fiske, CI Seye, CJ Dixon, D Erlinge, DA Cockayne, E Ghanem, E Rapaport, EB Gonzales, EW Inscho, EW Sutherland, F Di Virgilio, F Di Virgilio, F Di Virgilio, F Lippman, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Clark, H Franke, H Woodward, H Zimmermann, HZ Ke, I Bar, IF Gow, IP Chessell, J Korcok, J Li, J Nilsson, JA Burgers, JA Sim, JE Wilson, JF Chen, JF Chen, JL Madara, JM Armstrong, JM Sanz, JT Neary, K Inoue, K Inoue, K Inoue, K Lohmann, K Mulryan, K Wirkner, K Yamamoto, KA Moore, L Gimenez-Llort, L Li, M Horckmans, M Naassila, M Ryten, M Shabbir, M Shabbir, M Shabbir, M Sugioka, M Tsuda, MJ Bours, MJ Ludlow, MM Waldrop, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Meyer, MW Grol, MW Verghese, MY Avila, N Lenain, N Panupinthu, N White, N White, N White, PB Conley, R Brown, R Janssens, RA North, RA North, RJ Cerniway, S Kirischuk, S Kirischuk, S Pochet, S Ryzhov, SD Ohlendorff, SJ Fountain, SJ Fountain, SL Tilley, T Kawate, TE Finger, U Groschel-Stewart, U Groschel-Stewart, UK Hanisch, V Ralevic, V Ralevic, V Souslova, VL Cressman, X Bian, X Hua, Y Guo, Y Pankratov, Y Pankratov, Y Pankratov, Y Pankratov, YD Bogdanov, Z Xiang, Z Zhao   +139 more
core   +2 more sources

A New method for Analysis of Biomolecules Using the BSM-SG Atomic Models [PDF]

, 2017
Biomolecules and particularly proteins and DNA exhibit some mysterious features that cannot find satisfactory explanation by quantum mechanical modes of atoms.
Sargoytchev, Stoyan Sarg
core   +1 more source

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

Journal of Fungi, 2020
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver   +7 more
doaj   +1 more source

Metabolism of Pyrimidines and Pyrimidine Nucleosides by Salmonella typhimurium [PDF]

Journal of Bacteriology, 1972
The pathways by which uracil, cytosine, uridine, cytidine, deoxyuridine, and deoxycytidine are metabolized by Salmonella typhimurium are established. The various 5-fluoropyrimidine analogues are shown to exert their toxic effects only after having been converted to the nucleotide level, and these conversions are ...
Elisabeth Thomassen, John L. Ingraham, Jan Neuhard, Christoph F. Beck   +3 more
openaire   +3 more sources

Synthesis of pyrimidines by Fe3O4@SiO2-L-proline nanoparticles

Main Group Metal Chemistry, 2020
Fe3O4@SiO2-L-proline nanoparticles have been used as an effective catalyst for the preparation of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and 4-methyl aniline or 4-methoxy aniline under reflux condition
Safaei-Ghomi Javad, Samadi Zahra
doaj   +1 more source

Facile preparation and conversion of 4,4,4-trifluorobut-2-yn-1-ones to aromatic and heteroaromatic compounds

Beilstein Journal of Organic Chemistry, 2021
The concise preparation of 4,4,4-trifluorobut-2-yn-1-ones by the oxidation of the readily accessible corresponding propargylic alcohols as well as their utilization as Michael acceptors for the construction of aromatic and heteroaromatic compounds are ...
Takashi Yamazaki, Yoh Nakajima, Minato Iida, Tomoko Kawasaki-Takasuka   +3 more
doaj   +1 more source

Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells

Frontiers in Pharmacology, 2018
Most breast and prostate tumors are hormone-dependent, making it possible to use hormone therapy in patients with these tumors. The design of effective endocrine drugs that block the growth of tumors and have no severe side effects is a challenge ...
A. Scherbakov, A. Komkov, Anna S. Komendantova, M. Yastrebova, O. Andreeva, V. Shirinian, A. Hajra, I. Zavarzin, Yulia A. Volkova   +8 more
semanticscholar   +1 more source

Parallel Synthesis of 2-Substituted 6-(5-Oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides

Molecules, 2012
A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides <strong>10</strong>{<em>1</em>,<em>2</em>; <em>1–12</em>} was prepared by a parallel solution-phase approach.
Branko Stanovnik, Uroš Grošelj, Jurij Svete, Georg Dahmann, Drago Kočar, Jernej Baškovč, Bojana Črček   +6 more
doaj   +1 more source