Results 61 to 70 of about 104,207 (331)

Microscopically Adaptable Bioink Guide Cell Compartmentalization toward Morphogenesis of a Functional Vasculature‐Like System

Advanced Healthcare Materials, EarlyView.
Contractile vasculatures are fabricated through a one‐step bioprinting strategy. The adaptable microenvironment provided by ECM‐mimicking bioink triggers cell sorting and compartmentalization of endothelial cells and vascular smooth muscle cells toward a histological configuration by focal adhesion kinase‐mediated upregulation of cell adhesion and ...
Jun Chen, Yuqiong Wu, Jiarong Huang, Junjin Jie, Chan Huang, Di Zhang, Yuxin Huang, Rui Mao, Ming Zhao, Lin‐Ping Wu   +9 more
wiley   +1 more source

Triethylamine-Promoted Oxidative Cyclodimerization of 2H-Azirine-2-carboxylates to Pyrimidine-4,6-dicarboxylates: Experimental and DFT Study

Molecules, 2023
An unprecedented oxidative cyclodimerization reaction of 2H-azirine-2-carboxylates to pyrimidine-4,6-dicarboxylates under heating with triethylamine in air is described. In this reaction, one azirine molecule undergoes formal cleavage across the C-C bond
Timofei N. Zakharov, Pavel A. Sakharov, Mikhail S. Novikov, Alexander F. Khlebnikov, Nikolai V. Rostovskii   +4 more
doaj   +1 more source

Spontaneous assembly of an organic-inorganic nucleic acid Z-DNA double-helix structure [PDF]

, 2017
Herein, we report a hybrid polyoxometalate organic–inorganic compound, Na2[(HGMP)2Mo5O15]⋅7 H2O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally ...
Albrecht, Arnott, Barnes, Braga, Cafferty, Cairns-Smith, Carraro, Champ, Cooper, Crick, Ellena, Hill, Humphrey, Inoue, Kim, Kulikov, Kwak, Li, Maehigashi, Martins, Murayama, Nordén, Parker, Powner, Rich, Ritson, Soghomonian, Strandberg, Sun, Tang, Van Hecke, Vasconcelos, Voet, Wang, Wong, Yamase, Yu   +36 more
core   +1 more source

A search for interstellar pyrimidine [PDF]

Monthly Notices of the Royal Astronomical Society, 2003
8 pages, 5 figures, accepted for publication in ...
H. C. Huang, Yi-Jehng Kuan, Yi-Jehng Kuan, Chi-Hung Yan, Zbigniew Kisiel, Pascale Ehrenfreund, Steven B. Charnley   +6 more
openaire   +3 more sources

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells in vitro [PDF]

, 2016
A novel anti-tumor agent 4-thio-5-(2′′-thienyl)uridine (6) was synthesized and the in vitro cytotoxicity activity against mice colon cancer cells (MC-38) and human colon cancer cells (HT-29) was evaluated by MTT assay.
Li, Depeng, Ma, Kedong, Qin, Jianzhong, Xu, Yaozhong, Zhang, Xiaohui   +4 more
core   +1 more source

Synthesis of Polycyclic Oxazolinium Compounds from Aryloxazolines and Alkynes via Dual Photoredox/Gold Catalysis and Rhodium Catalysis

Advanced Synthesis &Catalysis, EarlyView.
A series of polycyclic oxazolinium compounds is synthesized from various aryloxazolines with silyl‐substituted alkynes and internal alkynes via dual photoredox/gold catalysis and Rh‐catalyzed C–H bond functionalization, and affords silyl‐substituted polycyclic oxazoliniums and polycyclic oxazoliniums, respectively.
Lai‐Yi Tsang, Ajcharapan Tantipanjaporn, Karen Ka‐Yan Kung, Hoi‐Yi Sit, Wa‐Yi O, Aries Kwok‐Heung Chan, Nathanael Chun‐Him Lai, Man‐Kin Wong   +7 more
wiley   +1 more source

Nitrogen doping of carbon nanoelectrodes for enhanced control of DNA translocation dynamics

, 2017
Controlling the dynamics of DNA translocation is a central issue in the emerging nanopore-based DNA sequencing. To address the potential of heteroatom doping of carbon nanostructures to achieve this goal, herein we carry out atomistic molecular dynamics ...
Cho, Art E., Jung, Sang Won, Kim, Han Seul, Kim, Yong-Hoon   +3 more
core   +9 more sources

Synthesis of 2-Substituted 9-Oxa-Guanines {5-Aminooxazolo 5,4-D Pyrimidin-7(6H)-Ones} and 9-Oxa-2-Thio-Xanthines{5-Mercaptooxazolo 5,4-D Pyrimidin-7(6H)-Ones} [PDF]

, 2008
Oxazolo[5,4-d] pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives.
Bai, Yan, Kerwin, Sean M., Li, Wen Tai, Mandal, Subrata, Robertus, Jon D.   +4 more
core   +3 more sources

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source