Results 1 to 10 of about 4,994 (242)

Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis [PDF]

Frontiers in Chemistry, 2021
The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of compounds in a whole-cell screen against Mycobacterium tuberculosis.
Erik J. Hembre, Julie V. Early, Joshua Odingo, Catherine Shelton, Olena Anoshchenko, Junitta Guzman, Lindsay Flint, Devon Dennison, Matthew B. McNeil, Aaron Korkegian, Yulia Ovechkina, Paul L. Ornstein, Thierry Masquelin, Philip A. Hipskind, Tanya Parish   +14 more
openalex   +3 more sources

CoMFA and CoMSIA Studies on Inhibitors of HIV‐1 Integrase ‐ Bicyclic Pyrimidinones [PDF]

E-Journal of Chemistry, 2010
To understand the structural requirements of HIV-1 integrase inhibitors and to design new ligands against human HIV-1 integrase with enhanced inhibitory potency, a 3D QSAR (quantitative structure-activity relationship) study with comparative molecular ...
V. Radhika, Sivan Sree Kanth, Vijjulatha Manga   +2 more
openalex   +2 more sources

Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides [PDF]

Metabolites, 2020
Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C.
Yaojie Guo, Jens C. Frisvad, Thomas O. Larsen   +2 more
openaire   +6 more sources

Synthesis and Antimicrobial Activity of Some New Pyrimidinone and Oxazinone Derivatives Fused with Thiophene Rings Using 2-Chloro-6-ethoxy-4-acetylpyridine as Starting Material [PDF]

Molecules, 2012
A series of pyridines, pyrimidinones, oxazinones and their derivatives were synthesized as antimicrobial agents using citrazinic acid (2,6-dihydroxyisonicotinic acid) as a starting material.
Aisha Hossan, Hana M. Abumelha, Mohamed A. Al‐Omar, Abd El‐Galil E. Amr   +3 more
openalex   +3 more sources

Competitive cyclization of ethyl trifluoroacetoacetate and methyl ketones with 1,3-diamino-2-propanol into hydrogenated oxazolo- and pyrimido-condensed pyridones. [PDF]

Beilstein J Org Chem
The use of 1,3-diamino-2-propanol with competitive N- and O-nucleophilic centers in a three-component cyclization with ethyl 4,4,4-trifluoroacetoacetate and methyl ketones enables the synthesis to be carried out for octahydropyrido[1,2-a]pyrimidin-6-ones
Kushch SO, Goryaeva MV, Burgart YV, Ezhikova MA, Kodess MI, Slepukhin PA, Volobueva AS, Zarubaev VV, Saloutin VI.   +8 more
europepmc   +2 more sources

Pyrrolopyrimidines: Design, Synthesis and Antitumor Properties of Novel Tricyclic Pyrrolo [2,3-<i>d</i>]pyrimidine Derivatives. [PDF]

Molecules
The pyrrolo[2,3-d]pyrimidine (7-deazapurine) scaffold is a unique heterocyclic system included in the composition of most nucleotides. In this study, series of the pyrrolo[2,3-d]pyrimidine-imines and 3-halo-substituted pyrrolo[2,3-d]pyrimidines were ...
Song B, Murtazaeva Z, Nie L, Kuryazov R, Gaybullaev S, Niu C, Bozorov K, Aisa HA, Zhao J.   +8 more
europepmc   +2 more sources

Connecting chemical structure to single cell signaling profiles. [PDF]

Commun Biol
A challenge in chemical biology is to study structure-activity relationships (SAR) in vivo in cells. Multiplexed activity profiling (MAP), developed for natural product discovery, is well-suited to address this challenge as it is high throughput ...
Thirman HL, Grider-Hayes MJ, Geben LC, Ihrie RA, Brown LE, Porco JA, Irish JM.   +6 more
europepmc   +2 more sources

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria. [PDF]

Sci Rep
The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically ...
van den Biggelaar RHGA, Walburg KV, van den Eeden SJF, van Doorn CLR, Meiler E, de Ries AS, Fusco MC, Meijer AH, Ottenhoff THM, Saris A.   +9 more
europepmc   +2 more sources

Access to Pyrazolo[1,5-<i>a</i>]pyrimidinone Regioisomers from Acylated Meldrum's Acids. [PDF]

Org Lett
Donzel M, Chorell E.
europepmc   +2 more sources

Synthesis of new binary trimethoxyphenylfuran pyrimidinones as proficient and sustainable corrosion inhibitors for carbon steel in acidic medium: experimental, surface morphology analysis, and theoretical studies. [PDF]

BMC Chem
In this study, synthesis and assessment of the corrosion inhibition of four new binary heterocyclic pyrimidinones on CS in 1.0 M hydrochloric acid solutions at various temperatures (30–50 °C) were investigated. The synthesized molecules were designed and
Ali HA, El-Hossiany AA, Abousalem AS, Ismail MA, Fouda AES, Ghaith EA.   +5 more
europepmc   +2 more sources