Results 1 to 10 of about 5,906 (227)

Synthesis of new binary trimethoxyphenylfuran pyrimidinones as proficient and sustainable corrosion inhibitors for carbon steel in acidic medium: experimental, surface morphology analysis, and theoretical studies [PDF]

BMC Chemistry
In this study, synthesis and assessment of the corrosion inhibition of four new binary heterocyclic pyrimidinones on CS in 1.0 M hydrochloric acid solutions at various temperatures (30–50 °C) were investigated. The synthesized molecules were designed and
Hajar A. Ali, Ahmed. A. El-Hossiany, Ashraf S. Abousalem, Mohamed A. Ismail, Abd El-Aziz S. Fouda, Eslam A. Ghaith   +5 more
doaj   +3 more sources

The Persistence of Hydrogen Bonds in Pyrimidinones: From Solution to Crystal [PDF]

ACS Organic & Inorganic Au
Pyrimidinone scaffolds are present in a wide array of molecules with synthetic and pharmacological utility. The inherent properties of these compounds may be attributed to intermolecular interactions analogous to the interactions that molecules tend to establish with active sites.
Fellipe F. S. Farias, Mateus Mittersteiner, Amanda M. Kieling, Priscila S. V. Lima, Gustavo H. Weimer, Helio G. Bonacorso, Nilo Zanatta, Marcos A. P. Martins   +7 more
doaj   +4 more sources

Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolopyrimidinones Tethered with Hydrazide-Hydrazones. [PDF]

International Journal of Molecular Sciences, 2021
Chemotherapy represents the most applied approach to cancer treatment. Owing to the frequent onset of chemoresistance and tumor relapses, there is an urgent need to discover novel and more effective anticancer drugs.
Caso, A., Costantino, V., DellaSala, G., D’Aria, F., Esposito, G., Giancola, C., Horchani,M., Jannet, H. B., Laurenzana, I., Romdhane, A.   +9 more
core   +2 more sources

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria [PDF]

Scientific Reports
The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically ...
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, M. Chiara Fusco, Annemarie H. Meijer, Tom H. M. Ottenhoff, Anno Saris   +9 more
doaj   +2 more sources

CoMFA and CoMSIA Studies on Inhibitors of HIV-1 Integrase - Bicyclic Pyrimidinones [PDF]

E-Journal of Chemistry, 2010
To understand the structural requirements of HIV-1 integrase inhibitors and to design new ligands against human HIV-1 integrase with enhanced inhibitory potency, a 3D QSAR (quantitative structure-activity relationship) study with comparative molecular ...
V. Radhika, S. Sree Kanth, M. Vijjulatha
doaj   +3 more sources

Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1,3-Thiazepinones, and 1,2,4-Triazolopyrimidines Derived from Quinoline-Pyrido[2,3-d] Pyrimidinones [PDF]

Pharmaceuticals
Background: Recently, pyrido[2,3-d] pyrimidine, triazolopyrimidine, thiazolopyrimidine, quinoline, and pyrazole derivatives have gained attention due to their diverse biological activities, including antimicrobial, antioxidant, antitubercular, antitumor,
Ameen Ali Abu-Hashem, Sami A. Al-Hussain
doaj   +2 more sources

Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis

Frontiers in Chemistry, 2021
The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of compounds in a whole-cell screen against Mycobacterium tuberculosis.
Erik Hembre, Julie V. Early, Joshua Odingo, Catherine Shelton, Olena Anoshchenko, Junitta Guzman, Lindsay Flint, Devon Dennison, Matthew B. McNeil, Aaron Korkegian, Yulia Ovechkina, Yulia Ovechkina, Paul Ornstein, Thierry Masquelin, Philip A. Hipskind, Tanya Parish, Tanya Parish   +16 more
doaj   +1 more source

WELPSA: A natural catalyst of alkali and alkaline earth metals for the facile synthesis of tetrahydrobenzo[b]pyrans and pyrano[2,3‐d]pyrimidinones as inhibitors of SARS‐CoV‐2

Applied organometallic chemistry, 2021
Since 2019, the infection of SARS‐CoV‐2 has been spreading worldwide and caused potentially lethal health problems. In view of this, the present study explores the most commodious and environmentally benign synthetic protocol for the synthesis of ...
A. Nesaragi, R. Kamble, Swati R. Hoolageri, Ahmedraza Mavazzan, Suresh F. Madar, A. Anand, S. Joshi   +6 more
semanticscholar   +1 more source

Crystal structures of (E)-2-amino-4-methylsulfanyl-6-oxo-1-(1-phenylethylideneamino)-1,6-dihydropyrimidine-5-carbonitrile and (E)-2-amino-4-methylsulfanyl-6-oxo-1-[1-(pyridin-2-yl)ethylideneamino]-1,6-dihydropyrimidine-5-carbonitrile

Acta Crystallographica Section E: Crystallographic Communications, 2021
The title compounds 3a, C14H13N5OS, and 3b, C13H12N6OS, both show an E configuration about the N=C bond and a planar NH2 group. The molecules, which only differ in the presence of a phenyl (in 3a) or pyridyl (in 3b) substituent, are closely similar ...
Reham A. Mohamed-Ezzat, Galal H. Elgemeie, Peter G. Jones   +2 more
doaj   +1 more source

Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors

RSC Advances, 2021
Sulphonated graphene oxide was used for cascade condensation and cyclization reactions towards accessing substituted pyrazolo pyrimidinones. Further, sulphonation and amination reactions were integrated through continuous flow chemistry to access PDE-5 ...
Vinay Kumar Sthalam, B. Mahajan, Purushotham Reddy Karra, Ajay K. Singh, Srihari Pabbaraja   +4 more
semanticscholar   +1 more source