Results 1 to 10 of about 3,593 (197)

Design, Synthesis, and Evaluation of Naphthyl Pyrazino‐Pyrido‐Pyrimidinones Targeting the Phosphoinositide 3‐Kinase/Alpha‐Serine/Protein Kinase B/Mammalian Target of Rapamycin Pathway [PDF]

ChemistryOpen
Cancer remains a leading global cause of death and a major public health concern, with rising incidence and mortality rates. Current treatments are often limited by tumor complexity and heterogeneity, emphasizing the need for novel, targeted, and ...
Marcelo F. Marchiori, Gabriel da Silva, Daniel F. Kawano, Andréia M. Leopoldino, Enrique Madruga, Ana Martinez, Ivone Carvalho   +6 more
doaj   +3 more sources

Competitive cyclization of ethyl trifluoroacetoacetate and methyl ketones with 1,3-diamino-2-propanol into hydrogenated oxazolo- and pyrimido-condensed pyridones [PDF]

Beilstein Journal of Organic Chemistry
The use of 1,3-diamino-2-propanol with competitive N- and O-nucleophilic centers in a three-component cyclization with ethyl 4,4,4-trifluoroacetoacetate and methyl ketones enables the synthesis to be carried out for octahydropyrido[1,2-a]pyrimidin-6-ones
Svetlana O. Kushch, Marina V. Goryaeva, Yanina V. Burgart, Marina A. Ezhikova, Mikhail I. Kodess, Pavel A. Slepukhin, Alexandrina S. Volobueva, Vladimir V. Zarubaev, Victor I. Saloutin   +8 more
doaj   +2 more sources

Pyrrolopyrimidines: Design, Synthesis and Antitumor Properties of Novel Tricyclic Pyrrolo [2,3-d]pyrimidine Derivatives [PDF]

Molecules
The pyrrolo[2,3-d]pyrimidine (7-deazapurine) scaffold is a unique heterocyclic system included in the composition of most nucleotides. In this study, series of the pyrrolo[2,3-d]pyrimidine-imines and 3-halo-substituted pyrrolo[2,3-d]pyrimidines were ...
Buer Song, Zarifa Murtazaeva, Lifei Nie, Rustamkhon Kuryazov, Shukhrat Gaybullaev, Chao Niu, Khurshed Bozorov, Haji Akber Aisa, Jiangyu Zhao   +8 more
doaj   +2 more sources

Connecting chemical structure to single cell signaling profiles [PDF]

Communications Biology
A challenge in chemical biology is to study structure-activity relationships (SAR) in vivo in cells. Multiplexed activity profiling (MAP), developed for natural product discovery, is well-suited to address this challenge as it is high throughput ...
Hannah L. Thirman, Madeline J. Grider-Hayes, Laura C. Geben, Rebecca A. Ihrie, Lauren E. Brown, John A. Porco, Jonathan M. Irish   +6 more
doaj   +2 more sources

Identification of kinase inhibitors as potential host-directed therapies for intracellular bacteria [PDF]

Scientific Reports
The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria, specifically ...
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, M. Chiara Fusco, Annemarie H. Meijer, Tom H. M. Ottenhoff, Anno Saris   +9 more
doaj   +2 more sources

The Persistence of Hydrogen Bonds in Pyrimidinones: From Solution to Crystal [PDF]

ACS Organic & Inorganic Au
Fellipe F. S. Farias, Mateus Mittersteiner, Amanda M. Kieling, Priscila S. V. Lima, Gustavo H. Weimer, Helio G. Bonacorso, Nilo Zanatta, Marcos A. P. Martins   +7 more
doaj   +2 more sources

Synthesis of new binary trimethoxyphenylfuran pyrimidinones as proficient and sustainable corrosion inhibitors for carbon steel in acidic medium: experimental, surface morphology analysis, and theoretical studies [PDF]

BMC Chemistry
In this study, synthesis and assessment of the corrosion inhibition of four new binary heterocyclic pyrimidinones on CS in 1.0 M hydrochloric acid solutions at various temperatures (30–50 °C) were investigated. The synthesized molecules were designed and
Hajar A. Ali, Ahmed. A. El-Hossiany, Ashraf S. Abousalem, Mohamed A. Ismail, Abd El-Aziz S. Fouda, Eslam A. Ghaith   +5 more
doaj   +2 more sources

Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis

Frontiers in Chemistry, 2021
The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of compounds in a whole-cell screen against Mycobacterium tuberculosis.
Erik Hembre, Julie V. Early, Joshua Odingo, Catherine Shelton, Olena Anoshchenko, Junitta Guzman, Lindsay Flint, Devon Dennison, Matthew B. McNeil, Aaron Korkegian, Yulia Ovechkina, Yulia Ovechkina, Paul Ornstein, Thierry Masquelin, Philip A. Hipskind, Tanya Parish, Tanya Parish   +16 more
doaj   +1 more source

Crystal structures of (E)-2-amino-4-methylsulfanyl-6-oxo-1-(1-phenylethylideneamino)-1,6-dihydropyrimidine-5-carbonitrile and (E)-2-amino-4-methylsulfanyl-6-oxo-1-[1-(pyridin-2-yl)ethylideneamino]-1,6-dihydropyrimidine-5-carbonitrile

Acta Crystallographica Section E: Crystallographic Communications, 2021
The title compounds 3a, C14H13N5OS, and 3b, C13H12N6OS, both show an E configuration about the N=C bond and a planar NH2 group. The molecules, which only differ in the presence of a phenyl (in 3a) or pyridyl (in 3b) substituent, are closely similar ...
Reham A. Mohamed-Ezzat, Galal H. Elgemeie, Peter G. Jones   +2 more
doaj   +1 more source

Cu-phthalocyanine Coated Hybrid Magnetic Nanoparticles: Preparation and Application in the Synthesis of Mono- and Bis pyrano[2,3-d]pyrimidinones and mono- and Bis-2-amino-4H-pyrans [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2020
In this research, Cu-phthalocyanine coated hybrid magnetic nanoparticles have been prepared in a simple method and evaluated as an efficient catalyst in the preparation of mono- and bis-pyrano[2,3-d]pyrimidinones and mono- and bis-2-amino-4H-pyrans from ...
Ali Reza Karimi, Fatemeh Bagherian, Marzie Karimi   +2 more
doaj   +1 more source