Scaffold-Hopping Design and Synthesis of Thieno[3,2-<i>d</i>]pyrimidines: Anticancer Activity, Apoptosis Induction, and In Silico Inhibition of CDKs. [PDF]
Int J Mol SciRuzi Z +9 more
europepmc +1 more source
BRAF <sup><b>V600E</b></sup> Metastatic Synovial Sarcoma Treated with BRAF & MEK Inhibitors Achieves Complete Response. A Case Report & Literature Review. [PDF]
Oncol ResBurg D +20 more
europepmc +1 more source
Efficacy of Combined Dabrafenib and Trametinib Therapy in BRAFV600E Mutant Intrahepatic Cholangiocarcinoma with a Neurofibromatosis Type 2 Mutation. [PDF]
Intern MedYoshida J +13 more
europepmc +1 more source
Targeting MET and KRAS G12C co-occurring mutation in metastatic adenoid cystic carcinoma of the trachea: a case report. [PDF]
J Med Case RepZhang L, Wang T, Xu Y, Ji Y, Nie K.
europepmc +1 more source
Trametinib-induced Hyponatremia in a Patient With Craniopharyngioma and Diabetes Insipidus. [PDF]
J Pediatr Hematol OncolGunasekara B +4 more
europepmc +1 more source
The chemistry of imidazoles and pyrimidinones [PDF]
The reactions of amino- and formylimidazoles, and aminopyrimidinones are described. Conditions were found for the successful condensation of 5(4)-aminoimidazole-4(5)-carboxamide with a number of substituted benzaldehydes, to provide a series of novel 5(4)-N-benzylideneaminoimidazole-4(5)-carboxamides. Reaction of a subset of the benzylidene derivatives
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Clinical outcomes of genomically guided trametinib monotherapy across cancer types: results from the IMPRESS-Norway trial. [PDF]
Acta OncolSlørdahl KS +18 more
europepmc +1 more source