A plain language summary describing changes in pain associated with uterine fibroids among women receiving relugolix combination therapy. [PDF]
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Nanoparticle-Catalysed Microwave-Driven MCRs for Sustainable Heterocycle Synthesis. [PDF]
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Targeted therapy for Langerhans cell histiocytosis with maxillofacial involvement in 20 children. [PDF]
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Recent advances in zirconium-based catalysis and its applications in organic synthesis: a review. [PDF]
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New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics
Archiv der Pharmazie, 2012AbstractA series of novel substituted pyrimidinones and fused pyrimidinones (compounds 3–18) were synthesized starting with oxiranylmethanone 2. The in vitro cytotoxicity against a human breast adenocarcinoma (MCF‐7) cell line was investigated and most of the tested compounds showed potent cytotoxic activity against the MCF‐7 cell line comparable to ...
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Ethynyltriisopropoxytitanium reactions with pyrimidinones
Journal of Organometallic Chemistry, 1988Abstract Ethynyltriisopropoxytitanium has been generated in situ from ethynyllithium and chlorotriisopropoxytitanium at −80°C. It forms 1 1 adducts with pyrimidin-2(1 H )-ones with exclusive carbon-carbon bond formation at C(6). The products after quenching ethynylmagnesium bromide with chlorotriisopropoxytitanium at −10°C are 1 1 the ...
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Synthesis of fluorinated pyrimidinones
Journal of Fluorine Chemistry, 2013Abstract A method for the construction of fluorinated pyrimidinones based on the reaction of cyanodifluoromethyl-substituted amines with isocyanates is described. The use of ortho-iodophenylisocyanate in this reaction followed by copper catalyzed intramolecular amination affords fluorinated fused heterocycles – 4-fluoropyrimido[1,6-a]benzimidazol-1 ...
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