Results 161 to 170 of about 3,637 (213)

Recent developments in the synthesis of tricyclic condensed pyrimidinones

Synthetic Communications, 2021
Abstract: Functionalized bicyclic pyrimidinones and their derivatives are significant heterocyclic scaffolds being their all-around prevalence in biologically potent compounds. In several attempts to explore the different synthetic methodologies for the construction of bicyclic condensed pyrimidinones, different researchers from all across the globe ...
Rayees Ahmad Naikoo, Rupesh Kumar, Vipan Kumar, Gaurav Bhargava   +3 more
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Ethynyltriisopropoxytitanium reactions with pyrimidinones

Journal of Organometallic Chemistry, 1988
Abstract Ethynyltriisopropoxytitanium has been generated in situ from ethynyllithium and chlorotriisopropoxytitanium at −80°C. It forms 1 1 adducts with pyrimidin-2(1 H )-ones with exclusive carbon-carbon bond formation at C(6). The products after quenching ethynylmagnesium bromide with chlorotriisopropoxytitanium at −10°C are 1 1 the ...
Frode Rise, David Grace, Kjell Undheim
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Pyrimidinones as biodynamic agents

1987
In view of the diverse types of biological activities associated with pyrimidinones and molecules having pyrimidinone as a component substructure, the pyrimidinone moiety may be considered as an important pharmacophore for incorporation in the design of molecules of biological interest.
A K, Saxena, S, Sinha
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ChemInform Abstract: New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics.

ChemInform, 2013
AbstractA series of new pyrimidinone derivatives is synthesized starting from oxiranyl aryl ketone (I).
Aymn E. Rashad, Ahmed H. Shamroukh, Nabil M. Yousif, Mowafia A. Salama, Hatem S. Ali, Mamdouh M. Ali, Abeer E. Mahmoud, Mahmoud El‐Shahat   +7 more
openaire   +1 more source

Formation and reactions of Dewar 4-pyrimidinones in the photochemistry of 4-pyrimidinones at low temperature. 2

The Journal of Organic Chemistry, 1983
Par photolyse de pyrimidones-4 en solution liquide NH 3 -ether a −40°C ou dans CH 3 OH de −10° a −40°C formation de lactames bicycliques de type Dewar et des autres produits formes ...
Tamiko Takahashi, Shunichi Hirokami, Kazuko Kato, Masanori Nagata, Takao Yamazaki   +4 more
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Syntheses of trifluoromethylated pyridinones and pyrimidinones

The Journal of Organic Chemistry, 1990
Les syntheses s'effectuent via la reaction d'orthoformiates avec des enaminonitriles ou avec des ...
Len F. Lee, Y. Larry Sing
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ChemInform Abstract: Photochemistry of 4‐Pyrimidinones. Part 7. Reaction of Dewar 4‐Pyrimidinone with Methylamine.

Chemischer Informationsdienst, 1982
AbstractDie Photolyse der Pyrimidinone (I) in flüssigem Methylamin (II) führt zu den offenkettigen Produkten (III), die bei der Chromatographie an Aluminiumoxid zu den Pyrimidinonen (IV) cyclisieren.
Y. HIRAI, H. KANMEI, T. YAMAZAKI, S. HIROKAMI   +3 more
openaire   +1 more source

Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribosides

Journal of Medicinal Chemistry, 1985
1-(2-Deoxy-beta-D-ribofuranosyl)-5-bromo-2-pyrimidinone (BrPdR) and 1-(2-deoxy-beta-D-ribofuranosyl)-5-iodo-2-pyrimidinone (IPdR) have been synthesized by condensation of the appropriate silylated bases 2a and 2b, respectively, with 3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-alpha-D-ribofuranosyl chloride (8) in 1,2-dichloroethane, in the presence of SnCl4 ...
S M, Efange, E M, Alessi, H C, Shih, Y C, Cheng, T J, Bardos   +4 more
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Antineoplastic properties of pyrimidinone interferon inducers

Advances in Enzyme Regulation, 1981
Abstract The interferon inducing, antiviral and antitumor activities of a new series of pyrimidinone compounds are compared and summarized in this report. An interesting split in mechanism of action appeared to exist in these compounds. One group represented by ABPP were very potent interferon inducing agents and the antiviral and antitumor activity ...
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An Unusual Condensation of Pyrimidinones: Synthesis of Bipyrimidinones and Bipyrimidinylmethane

HETEROCYCLES, 1991
An unusual condensation of pyrimidinones in the presence of lithiated furan derivatives or LiHMDS leads to the formation of 7, 8 and 13. In the case of the self condensation of 3, a novel acyloin reaction is invoked to explain the formation of product where the substrate acts as the catalyst in the ...
BOTTA M, SALADINO R, GAMBACORTA, Augusto, NICOLETTI R.   +3 more
openaire   +2 more sources