Encorafenib plus binimetinib versus dabrafenib plus trametinib for the first-line treatment of patients with BRAF<sup>V600E</sup>-mutant metastatic non-small cell lung cancer: a matching-adjusted indirect treatment comparison. [PDF]
ESMO OpenPlanchard D +6 more
europepmc +1 more source
Liquid biopsies for BRAF V600E assessment and monitoring in anaplastic thyroid carcinoma: a real-world study of a tertiary cancer center. [PDF]
EndocrineColombo E +24 more
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Ex-situ generation of gaseous nitriles in two-chamber glassware for facile haloacetimidate synthesis. [PDF]
Beilstein J Org ChemAkselvoll NB, Larsen JT, Pedersen CM.
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An Unusual Condensation of Pyrimidinones: Synthesis of Bipyrimidinones and Bipyrimidinylmethane [PDF]
HETEROCYCLES, 1991 An unusual condensation of pyrimidinones in the presence of lithiated furan derivatives or LiHMDS leads to the formation of 7, 8 and 13. In the case of the self condensation of 3, a novel acyloin reaction is invoked to explain the formation of product where the substrate acts as the catalyst in the ...
M. BOTTA +3 more
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Recent developments in the synthesis of tricyclic condensed pyrimidinones
Synthetic Communications, 2021Abstract: Functionalized bicyclic pyrimidinones and their derivatives are significant heterocyclic scaffolds being their all-around prevalence in biologically potent compounds. In several attempts to explore the different synthetic methodologies for the construction of bicyclic condensed pyrimidinones, different researchers from all across the globe ...
Rayees Ahmad Naikoo +3 more
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Synthesis of fluorinated pyrimidinones
Journal of Fluorine Chemistry, 2013Abstract A method for the construction of fluorinated pyrimidinones based on the reaction of cyanodifluoromethyl-substituted amines with isocyanates is described. The use of ortho-iodophenylisocyanate in this reaction followed by copper catalyzed intramolecular amination affords fluorinated fused heterocycles – 4-fluoropyrimido[1,6-a]benzimidazol-1 ...
Mikhail D Kosobokov +2 more
exaly +2 more sources
Synthesis, Antibacterial, and Antifungal Activities of Imidazo[2,1-c][1,2,4]triazoles and 1,2,4-Triazolo[4,3-a]pyrimidinones [PDF]
Synthetic Communications, 2014 A straightforward method has been developed for the synthesis of 1-phenyl-imidazo [2,1-c][1,2,4]triazole derivatives 5a–j and 1-phenyl-[1,2,4]triazolo[4,3-a]pyrimidinones derivatives 6a–g starting from 5-amino-1-phenyl[1,2,4]triazole and p ...
Dhekra Mhalla +2 more
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Pyrimidinones as reversible metaphase arresting agents
European Journal of Medicinal Chemistry, 1993Abstract 5-Halo- N (1)-substituted 2(1 H )-pyrimidinones have the ability to cause reversible arrest of mitosis during metaphase. Highly active compounds have a heteroatom ( O , S or N ) in the β-position of the N (1)-carbon chain which is further substituted by an aryl group. In vitro data have been provided.
T Benneche, R Oftebro, K Undheim
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Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides [PDF]
Tetrahedron Letters, 2003 Direct microwave-enhanced Sonogashira coupling of several pyrimidinones and uridine with alkynes, PdCl2(PPh3)2, Et 3N and CuI to give the corresponding 5-alkynyl derivatives is described. © 2003 Elsevier Ltd.
Elena Petricci +2 more
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The pyrido[2,3‐d]pyrimidine moieties are one of the most biologically widespread heterocyclic compounds as antimicrobial, antioxidant, antitubercular, antiviral and anti‐inflammatory. Hence, we synthesized an efficient new series of 2‐thioxo‐pyrido[2,3‐d]
A. Abu‐Hashem +3 more
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