Results 171 to 180 of about 5,835 (244)

Wang resin catalysed sonochemical synthesis of pyrazolo[4,3-d]pyrimidinones and 2,3-dihydroquinazolin-4(1H)-ones: Identification of chorismate mutase inhibitors having effects on Mycobacterium tuberculosis cell viability.

Bioorganic chemistry (Print), 2023
The enzyme chorismate mutase (or CM that is vital for the survival of bacteria) is an interesting pharmacological target for the identification of new anti-tubercular agents.
Sharda Shukla, R. Nishanth Rao, Harshavardhan Bhuktar, R. Edwin, Trinath Jamma, Raghavender Medishetti, Sharmistha Banerjee, Varadaraj Bhat Giliyaru, G. Shenoy, Srinivas Oruganti, P. Misra, M. Pal   +11 more
semanticscholar   +1 more source

New Insights about the Photostability of DNA/RNA Bases: Triplet nπ* State Leads to Effective Intersystem Crossing in Pyrimidinones.

Journal of Physical Chemistry B, 2021
The high photostability of DNA/RNA nucleobases is attributed to the effective internal conversions of their bright 1ππ* states to the ground state through conical intersections. Intersystem crossing (ISC) from singlet to triplet excited states is a minor
Kun Zhang, Fufang Wang, Yanrong Jiang, Xueli Wang, H. Pan, Zhenrong Sun, Haitao Sun, Jianhua Xu, Jinquan Chen   +8 more
semanticscholar   +1 more source

Research on anti-HIV-1 agents. Part 2: Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase [PDF]

Tetrahedron, 2001
A small library of 2,6-disubstituted- and 2,5,6-trisubstituted-4(3H)-pyrimidinones has been synthesized by solid-phase synthesis starting from a modified Merrifield resin. The new pyrimidinones have been tested in vitro for their ability to inhibit HIV-1
Maurizio Botta, Federico Corelli, Giovanni Maga   +2 more
exaly   +2 more sources

Application of cyclic-1,3-diketones in domino and multicomponent reactions: facile route to highly functionalized chromeno[2,3-d]pyrimidinones and diazabenzo[b]fluorenones under solvent-free conditions [PDF]

Tetrahedron Letters, 2010
A facile and efficient protocol for the synthesis of chromeno[2,3-d]pyrimidinones and diazabenzo[b]fluorenones has been developed by one-pot three-component cyclocondensation of aldehydes, cyclic-1,3-diketones and 1,3-dimethylbarbituric acid in the ...
Keshav Raghuvanshi, Rajiv Kumar Verma, Maya Shankar Singh   +2 more
exaly   +2 more sources

Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.

Bioorganic & Medicinal Chemistry Letters, 2020
This article describes the discovery of aryl hydroxy pyrimidinones and the medicinal chemistry efforts to optimize this chemotype for potent APJ agonism.
Michael C. Myers, Donna M. Bilder, C. Cavallaro, H. Chao, Shun Su, N. Burford, Akbar Nayeem, Tao Wang, Mujing Yan, Robert A. Langish, M. Dabros, Y. Li, Anne V. Rose, Kamelia Behnia, J. Onorato, Peter S. Gargalovic, R. Wexler, R. Lawrence   +17 more
semanticscholar   +1 more source

A facile one-pot synthesis of aryl-substituted fused pyrimidinones

Heterocyclic Communications, 2016
The convenient synthesis of a series of 3-phenylpyrido[1,2-a]pyrimidinones 4, 3-phenylpyrimido[1,2-c]quinazolinones 7 and 3-phenylpyrazino[1,2-a]pyrimidinones 10 with promising biological activity is presented.
Yang-Heon Song
exaly   +2 more sources

New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics

Archiv der Pharmazie, 2012
AbstractA series of novel substituted pyrimidinones and fused pyrimidinones (compounds 3–18) were synthesized starting with oxiranylmethanone 2. The in vitro cytotoxicity against a human breast adenocarcinoma (MCF‐7) cell line was investigated and most of the tested compounds showed potent cytotoxic activity against the MCF‐7 cell line comparable to ...
Aymn E, Rashad, Ahmed H, Shamroukh, Nabil M, Yousif, Mowafia A, Salama, Hatem S, Ali, Mamdouh M, Ali, Abeer E, Mahmoud, Mahmoud, El-Shahat   +7 more
openaire   +2 more sources

Rapid and mild synthesis of quinazolinones and chromeno[ d ]pyrimidinones using nanocrystalline copper(I) iodide under solvent-free conditions

Chinese Chemical Letters, 2016
Shahrzad Abdolmohammadi
exaly   +2 more sources

Ethynyltriisopropoxytitanium reactions with pyrimidinones

Journal of Organometallic Chemistry, 1988
Abstract Ethynyltriisopropoxytitanium has been generated in situ from ethynyllithium and chlorotriisopropoxytitanium at −80°C. It forms 1 1 adducts with pyrimidin-2(1 H )-ones with exclusive carbon-carbon bond formation at C(6). The products after quenching ethynylmagnesium bromide with chlorotriisopropoxytitanium at −10°C are 1 1 the ...
Frode Rise, David Grace, Kjell Undheim
openaire   +1 more source

Pyrimidinones as biodynamic agents

1987
In view of the diverse types of biological activities associated with pyrimidinones and molecules having pyrimidinone as a component substructure, the pyrimidinone moiety may be considered as an important pharmacophore for incorporation in the design of molecules of biological interest.
A K, Saxena, S, Sinha
openaire   +2 more sources