Results 181 to 190 of about 5,835 (244)

Design, synthesis and biological evaluation of novel pyrazolo-pyrimidinones as DPP-IV inhibitors in diabetes

Bioorganic and Medicinal Chemistry Letters, 2015
Sneha R Sagar, Dhaivat H Pandya, Ranjeet Prasad Dash   +2 more
exaly   +2 more sources

ChemInform Abstract: New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics.

ChemInform, 2013
AbstractA series of new pyrimidinone derivatives is synthesized starting from oxiranyl aryl ketone (I).
Aymn E. Rashad, Ahmed H. Shamroukh, Nabil M. Yousif, Mowafia A. Salama, Hatem S. Ali, Mamdouh M. Ali, Abeer E. Mahmoud, Mahmoud El‐Shahat   +7 more
openaire   +1 more source

Synthesis, modeling and biological evaluation of some pyrazolo[3,4-d]pyrimidinones and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidinones as anti-inflammatory agents.

Bioorganic chemistry (Print), 2019
New pyrazolo[3,4-d]pyrimidinone and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidinone derivatives were synthesized. They have been evaluated for their anti-inflammatory activity using in vitro (COX-1/COX-2) inhibitory assay.
Gina N. Tageldin, Tamer M. Ibrahim, Salwa M. Fahmy, H. Ashour, M. Khalil, Rasha A. Nassra, I. Labouta   +6 more
semanticscholar   +1 more source

Formation and reactions of Dewar 4-pyrimidinones in the photochemistry of 4-pyrimidinones at low temperature. 2

The Journal of Organic Chemistry, 1983
Par photolyse de pyrimidones-4 en solution liquide NH 3 -ether a −40°C ou dans CH 3 OH de −10° a −40°C formation de lactames bicycliques de type Dewar et des autres produits formes ...
Tamiko Takahashi, Shunichi Hirokami, Kazuko Kato, Masanori Nagata, Takao Yamazaki   +4 more
openaire   +1 more source

Facile and simple synthesis of pyrimido[4,5-d]pyrimidinones and pyrano[2,3-d]pyrimidinones catalyzed by nano-sized NS-C4(DABCO-SO3H)2·4Cl

Journal of the Iranian Chemical Society, 2017
Omid Goli-Jolodar, Farhad Shirini, Shirini Farhad   +2 more
exaly   +2 more sources

Syntheses of trifluoromethylated pyridinones and pyrimidinones

The Journal of Organic Chemistry, 1990
Les syntheses s'effectuent via la reaction d'orthoformiates avec des enaminonitriles ou avec des ...
Len F. Lee, Y. Larry Sing
openaire   +1 more source

Synthesis and anticonvulsant activities of functionalized 5-(isoindole-1,3-dione)-pyrimidinones

Medicinal Chemistry Research, 2016
Dinesh Y Gawande, Chander Mohan, Rajesh Kumar Goel   +2 more
exaly   +2 more sources

Identification of 2(1H)-pyrimidinones as potential EGFR T790M inhibitors for the treatment of gefitinib-resistant non-small cell lung cancer.

Bioorganic chemistry (Print), 2019
A new class of 2(1H)-pyrimidinone derivatives was identified as potential EGFR T790M inhibitors against TKI-resistant NSCLC. These novel compounds inhibited the EGFR T790M kinase activity at concentrations in the range of 85.3 to 519.9 nM. In particular,
Jianping Huang, Jiaxin Huang, Ning Wang, Luhong Wang, Lei Li, Changyuan Wang, Xiuli Sun, Yongming Li, Guoping Huang, Xiaodong Ma   +9 more
semanticscholar   +1 more source

Mn(OAc)3-Mediated Regioselective Radical Alkoxycarbonylation of Indoles, Pyrimidinones, and Pyridinones

Synthesis, 2018
Mn(OAc)3-mediated alkoxycarbonylation of indoles, pyrimidinones, and pyridinones with alkyl carbazates is reported. The reactions proceed through a radical process to afford regioselectively 3-carboxylated indoles, 5-carboxylated pyrimidinones, and 3 ...
Cheng-Kun Li, Dong‐Liang Zhang, Ogundipe Olukayode Olamiji, Pei-zhi Zhang, Adedamola Shoberu, J. Zou, Wei Zhang   +6 more
semanticscholar   +1 more source

Introduction of Poly(4-Vinylpyridine) as an Efficient Promotor for the Synthesis of Pyrano[2,3-d]Pyrimidinones and Pyrido[2,3-d]Pyrimidines

Polycyclic aromatic compounds (Print), 2018
This article describes an efficient method for the synthesis of pyrano[2,3-d]pyrimidinones and pyrido[2,3-d]pyrimidines via promotion of the condensation of aromatic aldehydes, malononitrile and barbituric acid and/or 6-amino-1,3-dimethyluracil in the ...
Leyla Nazemi Nasirmahale, F. Shirini, O. Goli-Jolodar, H. Tajik   +3 more
semanticscholar   +1 more source