Results 221 to 230 of about 4,994 (242)

ChemInform Abstract: Synthesis of Fluorinated Pyrimidinones.

ChemInform, 2013
AbstractFluorinated pyrimidinones are constructed in two steps from cyanodifluoromethyl‐substituted amines and isocyanates.
Mikhail D. Kosobokov, Marina I. Struchkova, Dmitry E. Arkhipov, Alexander A. Korlyukov, Alexander D. Dilman   +4 more
openaire   +1 more source

SNAr Reactions of 2-Methylthio-4-pyrimidinones in Pivalic Acid: Access to Functionalized Pyrimidinones and Pyrimidines

Synthesis, 2012
Pivalic acid is a useful medium to effect the direct SNAr displacement of 2-methylthio-4-pyrimidinones with a variety of anilines. Products are easily isolated in good to excellent yields, and following chlorination, provide an opportunity to rapidly query structure-activity relationships at the 4-position of functionalized pyrimidines.
Matthew Maddess, Rhiannon Carter
openaire   +1 more source

(E)- and (Z)-Enamine Dewar Pyrimidinones

Acta Crystallographica Section C Crystal Structure Communications, 1995
The structures of (E)- and (Z)-methyl 1,6-dimethyl-5-oxo-2,6-diazabicyclo[2.2.0]hex-3-ylideneacetate, C 9 H 12 N 2 O 3 , have been established by X-ray diffraction analyses. The 2-azetidinone ring, azetidine ring and enamine moiety in both isomers are quite planar.
H. Kakuda, Y. Takahashi, S. i. Hirokami
openaire   +1 more source

New morpholine-containing pyrimidinones act on α-adrenoceptors

European Journal of Pharmacology
Drugs that act on α-adrenoceptors may contain morpholine and pyrimidinone heterocycles. The aim of this study was to synthesize a series of pyrimidinones (S6a-e and S8) and characterize their α-adrenoceptor activity. Cytotoxicity assays (MTT and LDH) were performed in A7r5 and HUVECs. Concentration-effect curves to phenylephrine (Phe) were performed in
Silvia Maria de Luna Alves, Sidiane Barros da Silva, Ruth Cristina Albuquerque Santos, Sidney Gustavo Feitosa, Paulo Henrique Miranda de Farias, Josenildo Alves Silva-Júnior, Daniel Rodrigues, Simone Regina Potje, Rita C. Tostes, Janaína Versiani dos Anjos, Alice Valença Araújo   +10 more
openaire   +2 more sources

Pyrimidinones

Reactions Weekly, 2017
openaire   +1 more source

Antiviral and other bioactivities of pyrimidinones

Pharmacology & Therapeutics, 1985
openaire   +2 more sources

Tautomerism of 2-ethoxy-4-pyrimidinone

The Journal of Organic Chemistry, 1970
openaire   +2 more sources

�ber 2,3-Dihydro-4(1H)-pyrimidinone

Monatshefte f�r Chemie, 1977
G. G�bitz, R. Wintersteiger, A. Fuchsgruber, G. Zigeuner   +3 more
openaire   +1 more source

85 C4H4N2O 4(3H)-Pyrimidinone

2014
E. Hirota, K. Kuchitsu, T. Steimle, J. Vogt, N. Vogt   +4 more
openaire   +1 more source

Pyrimidinones by Dehydrogenation

2011
openaire   +1 more source