Results 111 to 120 of about 88,038 (326)

Autoinflammatory diseases. Part 2. Pyrin inflammasomopathies and other enhanced interleukin 1 signaling syndromes

Zdorovʹe Rebenka
Systemic autoinflammatory diseases (SAIDs) are considered dysregulation disorders of the innate immune system characterized by systemic sterile inflammation independent of infection and autoreactive antibodies or antigen-specific T cells ...
О.В. Шварацька, Т.А. Бордій, К.К. Годяцька, М.В. Калічевська, О.В. Клименко, О.М. Таран, О.В. Клімова, Я.В. Віленський   +7 more
doaj   +1 more source

Involvement of Nucleotide-Binding Oligomerization Domain-Like Receptor Family Pyrin Domain Containing 3 Inflammasome in the Pathogenesis of Liver Diseases

Frontiers in Cell and Developmental Biology, 2020
The inflammasome is widely acknowledged for its crucial role in the pathogenesis of cancers and many neurodegenerative, metabolic, and auto-inflammatory diseases in recent years. Multiple types of inflammasomes exist.
Congjian Shi, Hongqin Yang, Zhenghong Zhang   +2 more
semanticscholar   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Communications Biology, 2022
This review discusses emerging roles for the NLR family pyrin domain containing 6 receptor (NLRP6) in intestinal homeostasis, inflammation, cancer, the nervous system and liver disease.
Diego Angosto-Bazarra, Cristina Molina-López, Pablo Pelegrín   +2 more
doaj   +1 more source

Transmigration of Neutrophils From Patients With Familial Mediterranean Fever Causes Increased Cell Activation

Frontiers in Immunology, 2021
Familial Mediterranean fever (FMF) is caused by pyrin-encoding MEFV gene mutations and characterized by the self-limiting periods of intense inflammation, which are mainly mediated by a massive influx of polymorphonuclear neutrophils (PMNs) into the ...
Anush Martirosyan, David Poghosyan, Susanna Ghonyan, Nune Mkrtchyan, Nune Mkrtchyan, Gayane Amaryan, Gayane Amaryan, Gayane Manukyan   +7 more
doaj   +1 more source

Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.

FEBS Letters, 2020
Inflammasomes are cytosolic multimeric signaling complexes of the innate immune system that induce activation of caspases. The NOD-like receptor NLRP9 recruits the adaptor protein ASC to form an ASC-dependent inflammasome to limit rotaviral replication ...
M. Marleaux, K. Anand, E. Latz, M. Geyer
semanticscholar   +1 more source

Pyrin Inflammasome Activation Abrogates Interleukin‐1 Receptor Antagonist, Suggesting a New Mechanism Underlying Familial Mediterranean Fever Pathogenesis

Arthritis & Rheumatology, 2021
Aberrant pyrin inflammasome activity triggers familial Mediterranean fever (FMF) pathogenesis, but the exact mechanism remains elusive and an obstacle to efficient treatment.
S. Mortensen, A. E. Hansen, T. Mogensen, M. Jakobsen, H. C. Beck, Eva B Harvald, K. Lambertsen, I. Johansen, D. C. Andersen   +8 more
semanticscholar   +1 more source

Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes [PDF]

, 2019
Excessive exposure to ultraviolet (UV) radiation is the main risk factor to develop skin pathologies or cancer because it encourages oxidative condition and skin inflammation.
Motilva Sánchez, Virginia, Oliveira, Helena, Rodríguez Luna, Azahara María, Talero Barrientos, Elena Mª, Ávila Román, Francisco Javier   +4 more
core   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Francisella induced microparticulate caspase-1/gasdermin-D activation is regulated by NLRP3 independent of Pyrin.

PLoS ONE, 2018
Although the study of pathogen sensing by host defense systems continues to uncover a role for inflammasome components specific to particular pathogens, gaps remain in our knowledge.
Srabani Mitra, Erin Dolvin, Karthikeyan Krishnamurthy, Mark D Wewers, Anasuya Sarkar   +4 more
doaj   +1 more source